TPCA-1

CAS: 507475-17-4

Ref. TR-T700500

Produktinformation

• Name: TPCA-1
• Synonyme: 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide, 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxylic acid amide, IKK 2 Inhibitor IV, 2-((Aminocarbonyl)Amino)-5-(4-Fluorophenyl)-3-Thiophenecarboxamide, 3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-

Beschreibung

Applications TPCA-1 is a direct dual inhibitor for both IKKβ (IKK-2) and STAT3. It inhibits STAT3 phosphorylation, DNA binding, and transactivation in vivo. Synergistic treatment of TPCA-1 with tyrosine kinase inhibitors (TKIs) can potentially be a more effective method for treating cancers.
References Nan, J., et al.: Mol. Cancer Ther., 13, 617 (2014); Birrell, M.A., et al.: Am. J. Respir. Crit. Care Med., 172, 962 (2005); Birrell, M.A., et al.: Mol. Pharmacol., 69, 1791 (2006)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 279.2901
• Formel: C₁₂H₁₀FN₃O₂S
• Farbe/Form: Light Beige Solid
• InChl: InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
• InChI Key: InChIKey=UFQNQEIAGBZCBL-YOEHRIQHSA-N
• SMILES: COc1ccc2c3c1O[C@H]1CC(=O)CC[C@@]31CCN(C)C2