N-4-(2,2,2-Trifluoroacetamido) Emtricitabine O-2,2,2-Trifluoroacetic Anhydride

Ref. TR-T781455

Produktinformation

• Name: N-4-(2,2,2-Trifluoroacetamido) Emtricitabine O-2,2,2-Trifluoroacetic Anhydride
• Synonyme: [[(2R,5S)-5-[5-fluoro-2-oxo-4-[(2,2,2-trifluoroacetyl)amino]pyrimidin-1-yl]-1,3-oxathiolan-2-yl]methoxy-hydroxyphosphoryl] 2,2,2-trifluoroacetate

Beschreibung

Applications N-4-(2,2,2-Trifluoroacetamido) Emtricitabine O-2,2,2-Trifluoroacetic Anhydride is an intermediate used in the synthesis of Emtricitabine Triphosphate Triethylammonium Salt (E525075), which is a metabolite of (-)-Emtricitabine (E525000).
References Barditch-Crovo, P., et al.: Antimicrob. Agents Chemother., 45, 2733 (2001); Ray, A., et al.: Antivir .Ther., 10, 451 (2005); Borroto-Esoda, K., et al.: Antivir. Ther., 11, 377 (2006)

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 519.243
• Formel: C₁₂H₉F₇N₃O₈PS
• Farbe/Form: Neat
• InChl: InChI=1S/C12H9F7N3O8PS/c13-4-1-22(10(25)21-7(4)20-8(23)11(14,15)16)5-3-32-6(29-5)2-28-31(26,27)30-9(24)12(17,18)19/h1,5-6H,2-3H2,(H,26,27)(H,20,21,23,25)/t5-,6+/m0/s1
• InChI Key: InChIKey=BNJFOVSHEOFXDQ-NTSWFWBYSA-N
• SMILES: O=C(Nc1nc(=O)n([C@@H]2CS[C@H](COP(=O)(O)OC(=O)C(F)(F)F)O2)cc1F)C(F)(F)F