Val-Ala-PAB

CAS: 1343476-44-7

Ref. TR-V091550

Produktinformation

• Name: Val-Ala-PAB
• Synonyme: L-Valyl-N-[4-(hydroxymethyl)phenyl]-L-alaninamide

Beschreibung

Applications Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing peptide linkers useful for treating proliferative including cancer.
References Dimasi, N., et al.: Mol. Pharm., 14, 1501 (2017); Howard, P. W., et al.: PCT Int. Appl. (2011), WO 2011130598 A1 20111020

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 293.36
• Formel: C₁₅H₂₃N₃O₃
• Farbe/Form: Neat
• InChl: InChI=1S/C15H23N3O3/c1-9(2)13(16)15(21)17-10(3)14(20)18-12-6-4-11(8-19)5-7-12/h4-7,9-10,13,19H,8,16H2,1-3H3,(H,17,21)(H,18,20)/t10-,13-/m0/s1
• InChI Key: InChIKey=NNWYWNRCBPYLML-GWCFXTLKSA-N
• SMILES: CC(C)[C@H](N)C(=O)N[C@@H](C)C(=O)Nc1ccc(CO)cc1