Produktinformation
Name:Zoledronic acid
Kontrolliertes Produkt
Synonyme:
- Phosphonic acid
- [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis- (9CI)
- (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
- 1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene-1,1-bisphosphonic acid
- 2-(Imidazol-1-yl)-1-hydroxy-1,1'-ethylidenediphosphonic acid
- Aclasta
- BPH 91
- CGP 42446
- Orazol
- Reclast
- ZOL 446
- Zoledronate
- Zometa
- Phosphonic acid
- Weitere Synonyme anzeigen
Marke:TRC
Beschreibung:Stability extremely hygroscopic
Applications Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
References Jagdev, S., et al.: Br. J. Cancer, 84, 1126 (2001); Viereck, V., et al.: Biochem. Biophys. Res. Commun., 291, 680-686.Croucher. P., et al.: J. Bone Miner. Res., 2003, 18(3), 482-492.
Applications Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
References Jagdev, S., et al.: Br. J. Cancer, 84, 1126 (2001); Viereck, V., et al.: Biochem. Biophys. Res. Commun., 291, 680-686.Croucher. P., et al.: J. Bone Miner. Res., 2003, 18(3), 482-492.
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Chemische Eigenschaften
Molekulargewicht:272.09
Formel:C5H10N2O7P2
Farbe/Form:Neat
InChl:InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
InChI Key:InChIKey=ZFXFMGARFHRTTO-UHFFFAOYSA-N
SMILES:COc1ccc(CC(=O)O)c(OC)c1