ZSTK 474

CAS: 475110-96-4

Ref. TR-Z701000

Produktinformation

• Name: ZSTK 474
• Synonyme: 2-(Difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-1H-benzimidazole, 1H-Benzimidazole, 2-(difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-, 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-bis(morpholino)-1,3,5-triazine, 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine, Tcmdc-137004, Zstk 474, Zstk474, 4,4′-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine

Beschreibung

Applications ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase (PI3K) isoforms. Potent PI3K inhibitor.
References Yaguchi, S., et al.: J. Natl. Cancer Inst., 98, 545 (2006); Kong, D., et al.: Cancer Sci., 98, 1638 (2007); Kong, D., et al.: Eur. J. Cancer, 45, 857 (2009); Marone, R., et al.: Mol. Cancer Res., 7, 601 (2009); Yang, S., et al.: PLoS One, 6, e26343 (2011); Haruta, K., et al.: Inflamm, Res., 61, 551 (2012);

• Marke: TRC

Chemische Eigenschaften

• Molekulargewicht: 417.41
• Formel: C₁₉H₂₁F₂N₇O₂
• Farbe/Form: Neat
• InChl: InChI=1S/C10H12O4/c1-4-13-10(12)9-7(3)8(11)6(2)5-14-9/h5H,4H2,1-3H3
• InChI Key: InChIKey=OUVHQEZDGIOBSW-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1occ(C)c(=O)c1C