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anticancer

Aristolone (Aristofone) has potential anti-cancer activity.

<p>Angelic anhydride, a (Z)-2-Methylbut-2-enoic anhydride derivative, helps synthesize pain-relief agents in butterbur.</p>

Incensole boosts β-cells and insulin secretion, raising body weight and liver glycogen in rats.

Erioside (mulberroside B) can antitussive, antiasthmatic, hypoglycemic, anti-tumor, treatment of gout.

Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.

<p>1.</p>

BMS-337197 is an IMPDH inhibitor.

<p>4-Hydroxybenzoate sodium is a benzoic acid derivative widely used in biochemical experiments and drug synthesis research.</p>

Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol is a heme oxygenase (HO) inhibitor. By inhibiting HO activity, it reduces the release of hypothalamic hormones AVP, OT, and ANP triggered by hyperosmolarity. This compound is also applicable for research related to hyperbilirubinemia.

L-Arginine-7-amido-4-methylcoumarin hydrochloride is a specific fluorescent substrate for cathepsin H, a substrate for the amino acid protease AP II.

β-1,3-N-Acetylglucosaminyltransferase 4 (EC:2.4.1.149, B3GNT4) is involved in the synthesis of poly-N-acetyllactosamine and functions with activity towards type 2 oligosaccharides.

ST6Sialyltransferase1 (EC:2.4.3.3, ST6GALNAC1, SIAT7A, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1) connects salivary acid, N-acetylneuraminic acid (NeuAc) ST6Sialyltransferase1 plays a key role in the pathogenesis of cancer by transferring sialic acid, N-acetylneuraminic acid (NeuAc), to O-linked GalNAc residues via an alpha-2,6 linkage.

Protein O-Glucosyltransferase 1 is a glucosyltransferase that modifies the Notch signaling pathway by attaching glucose to serine residues within Notch.

β-1,4-Galactosyltransferase 2 exhibits unique specificity for the donor substrate UDP-galactose and transfers galactose in the β1,4 linkage form.

Fucosyltransferase 11 (EC:2.4.1.-, FUT11) attaches α-L-fucose to glycoprotein substrates, specifically on asialoglycoprotein glycans and biantennary N-glycan acceptors. This enzyme is significant in the field of oncology.

Protamine from salmon is a biochemical reagent with antioxidant, anti-heparin, and antimicrobial properties. It can neutralize the anticoagulant effect of heparin, preventing the formation of antithrombin complexes in canine samples pretreated with heparin in vitro.

Deuteroporphyrin IX (dihydrochloride) is a photosensitizer known for its high lipophilicity and amphiphilicity, which enables it to impart photosensitivity to cell membrane systems. Additionally, Deuteroporphyrin IX (dihydrochloride) can induce irreversible discharge elimination in individual neurons.

<p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>

<p>Ala-Phe-Pro-pNA TFA serves as a chromogenic substrate for tripeptidyl peptidase and can be utilized to assess the enzyme's activity.</p>

Benzoyl coenzyme A (sodium) is the sodium salt form of Benzoyl coenzyme A. It is a derivative of coenzyme A (CoA), where the thiol group of CoA is linked to a benzoyl group. This compound serves as a substrate in acyl transfer reactions, playing a role in catalysis. Benzoyl coenzyme A (sodium) is a versatile metabolic intermediate used in studies exploring enzyme substrate specificity, metabolic regulation, and drug metabolism.

INCB-056868 is the metabolite M11 of Epacadostat. It serves as a substrate for BCRP and holds potential for use in the study of metabolic diseases.

Glycerophosphoglycerol is a precursor in phospholipid synthesis. By enhancing phospholipid formation, it aids in the reconstruction and proliferation of membrane structures in tumor cells. Glycerophosphoglycerol holds promise for research in breast cancer cells.

<p>3-Methoxypyridine is a pyridine derivative containing a methoxy group, commonly used as an organic synthesis intermediate</p>

<p>1,3-Cyclopentanedione is a cyclic β-diketone, widely used in biochemical experiments and drug synthesis research.</p>

2,6-Dimethoxybenzaldehyde inhibits the survival of J-774 cells and Mycobacterium tuberculosis and can be used in the study of tuberculosis.

<p>1H-Imidazole-2-carbaldehyde is an imidazole containing an aldehyde group, widely used in biochemical experiments and drug synthesis research.</p>

<p>2,6-Dimethyl-4H-pyran-4-one is a pyran derivative widely used in biochemical experiments and drug synthesis research.</p>

<p>5-Methylpyridin-2(1H)-one is a pyridine derivative widely used in biochemical experiments and drug synthesis research.</p>

2-Cyclopentenone can inhibit the activity of HepG2 cells and has inhibitory activity against urease in Sporosarcina pasteurii.

<p>Dimedone is a cyclic β-diketone widely used in biochemical experiments and drug synthesis research.</p>

<p>(+)-Solketal is a product of glycerol acetalisation and is widely used in research and experiments in the field of life sciences.</p>

DL-Homoserine is an unnatural amino acid that is active against homoserine kinases and dehydrogenases in biochemical experiments and organic synthesis.

3-Nitrophenylboronic acid has antibacterial activity and can be used in research and experiments in the field of life sciences.

<p>1-Acetylnaphthalene is a naphthalene derivative widely used in biochemical experiments and drug synthesis research.</p>

5-Methylindole is a indole that inhibits a variety of kinases in bacteria and animals and Tryptophan synthase in plants for leukaemia and Alzheimer's disease.

3,5-Dimethoxybenzaldehyde is an aromatic aldehyde, widely used in biochemical experiments and drug synthesis research.

<p>4,4'-Dichlorobenzophenone is a chlorinated aromatic compound primarily used in the synthesis of polymers (such as PEEK)</p>

<p>3-Hydroxytetradecanoic acid is a natural saturated fatty acid and a component of bacterial LPS, composition of lipids and the synthesis of surfactants</p>

<p>6-Methoxyquinoline is a quinoline derivative commonly used as an intermediate in antimicrobial drugs, widely applied in biochemical experiments</p>

Perylene is a polycyclic aromatic hydrocarbon (PAH) composed of multiple fused benzene rings, used as a photosensitiser and fluorescent probe

<p>(E)-Pent-2-enal is an unsaturated aldehyde compound widely used in biochemical experiments and drug synthesis research.</p>

<p>5-Hexen-1-ol is an unsaturated alcohol compound widely used in biochemical experiments and drug synthesis research.</p>

<p>Nonanoic acid Sodiumis a high purity biochemical reagent that can be used in research related to life sciences.</p>

<p>1H-Indol-5-amine (5-Aminoindole) is an indole derivative that can be used as an absorbent in (HCIC) and for the synthesis of tetracyclic heterocycles.</p>

<p>1-Pyrenamine is a polycyclic aromatic hydrocarbon (PAH) derivative commonly used as a catalyst carrier in methanol batteries</p>

<p>3-Hydroxy-4-methylbenzoic acid is a benzoic acid derivative widely used in biochemical experiments and drug synthesis research.</p>

<p>Butyramide is a fatty amide widely used in biochemical experiments and drug synthesis research.</p>

<p>2-Methyl-2-hexanol is a branched-chain fatty alcohol and tertiary alcohol compound widely used in biochemical experiments and drug synthesis research.</p>

<p>Lactic acid Lithium is a compound of lithium salt with lactic acid, which can be used for related research in the life sciences.</p>

<p>N-Caproicacid sodium is a highly pure biochemical reagent that acts as an agonist for Hydroxycarboxylic acid receptor 2 (EC50=113 μM).</p>

DL-4-Hydroxy-2-ketoglutarate is a gamma-keto acid and glutamic acid analogue that serves as a substrate for enzymes and a lysine analogue in metabolic studies.

Chlorophyll b is an orally active tetrapyrrole derivative and pigment that can be obtained from photosynthetic organisms such as plants and algae. It acts as a hydrogen donor and enhances glutathione levels. Chlorophyll b possesses antioxidant activity and functionally replaces chlorophyll a in photosystem II to participate in photosynthesis. It reduces DNA damage, chromosome instability, and oxidative stress induced by Cisplatin (HY-17394). Chlorophyll b is primarily used in research on plant photosynthesis mechanisms.

<p>DL-Ornithine hydrochloride is the hydrochloride salt form of DL-ornithine. It can serve as a potent supplement, influencing the secretion of anabolic hormones, fuel supply during exercise, stress-related mental performance, and preventing exercise-induced muscle damage.</p>

Enrofloxacin-OVA is a hapten-carrier protein conjugate formed by coupling Enrofloxacin to chicken ovalbumin (OVA). As a hapten, Enrofloxacin alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity.Enrofloxacin-OVA may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M TBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Pyrazinamide-KLH is a hapten-carrier protein conjugate formed by coupling Pyrazinamide to keyhole limpet hemocyanin (KLH). As a hapten, Pyrazinamide alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Pyrazinamide-KLH may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M PBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Penicillin G-OVA is a hapten-carrier protein conjugate formed by coupling Penicillin G to chicken ovalbumin (OVA). As a hapten, Penicillin G alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity.Penicillin G-OVA may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M TBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Gentamicin-BSA is a hapten-carrier protein conjugate formed by coupling Gentamicin to bovine serum albumin (BSA). As a hapten, Gentamicin alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Gentamicin-BSA may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M TBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Enrofloxacin-BSA is a hapten-carrier protein conjugate formed by coupling Enrofloxacin to bovine serum albumin (BSA). As a hapten, Enrofloxacin alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Enrofloxacin-BSA may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M TBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Poly-L-γ-glutamic acid (sodium) is an amino acid polymer.

4-Hydroxyclonidine is a metabolite of Clonidine. It is equally effective as Clonidine in displacing labeled Clonidine from antibodies.

<p>DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker where Val-Cit is specifically cleaved by Cathepsin B. The PNP group can be substituted by amine-containing payloads, and DBCO undergoes click chemistry reactions with azide molecules.</p>

Mal-Amide-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

C14-490 is an ionizable cationic lipid (pKa= 5.94) utilized in the synthesis of lipid nanoparticles (LNPs). These LNPs serve as a platform for subsequent gene editing studies in hematopoietic stem cells (HSCs) in utero. C14-490 LNPs encapsulate SpCas9 mRNA and TTR sgRNA, employing an optimized B5 formulation parameter, and are further enhanced by the surface attachment of CD45 antibody F(ab’)2 fragments to create Systemically Targeted Editing Mechanism LNPs (STEM LNPs).

Fmoc-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized to attach reactive groups (e.g., PNP) for drug payload conjugation. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases, enabling efficient payload release into cells.

<p>OSI-413 (free base) (CP 373413) is the primary metabolite of Erlotinib. Erlotinib (CP-358774) acts as a direct EGFR tyrosine kinase inhibitor with an IC50 of 2 nM against human EGFR.</p>

Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker comprising a maleimide group, a PEG spacer, a Val-Cit dipeptide, PAB, and a PNP carbonate. The maleimide serves as a thiol-specific covalent connector for labeling cysteine residues in proteins, whereas the PNP group acts as a highly reactive leaving group. The Val-Cit linker is cleaved by cytoplasmic peptidases.

Mc-d-Val-d-Cit-PAB-PNP is a cleavable (cleavable) ADC linker employed in the synthesis of antibody-drug conjugates (ADCs).

<p>Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker, featuring a maleimide group, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB moiety. The maleimide group allows covalent bonding to free thiols on cysteine residues of proteins. The Val-Cit dipeptide is cleaved intracellularly by cathepsins to facilitate payload delivery via the PAB structure.</p>

Fmoc-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker that features a Boc-protected amine, hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on the PAB can be used for conjugating reactive groups (e.g., PNP) to attach a payload. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases to efficiently release the payload inside cells.

<p>Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone. Buspirone is an orally active 5-HT1A receptor agonist and a dopamine D2 (dopamine D2) autoreceptor antagonist. It is an anxiolytic agent used for research in generalized anxiety disorder.</p>

7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone. Risperidone acts as a 5-HT2 receptor blocker, an inhibitor of P-glycoprotein (P-Glycoprotein), and an antagonist of the dopamine D2 receptor.

NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC (antibody-drug conjugate) linker characterized by a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on PAB facilitates conjugation with reactive groups like PNP, enabling attachment to drug payloads. The primary amine readily participates in various reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, and other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular proteases, allowing efficient payload delivery through an elimination mechanism within the PAB structure.

Boc-Gly-Gly-Gly-Gly-Gly is a protease-cleavable ADC linker with a Boc group at the N-terminus, utilized in the development of antibody-drug conjugates (ADC). The Boc group can be deprotected under mild acidic conditions, resulting in a free amine.

<p>Thalidomide-CH2NH2 hydrochloride is an analog of Thalidomide, characterized by a primary amine group. This primary amine is a versatile functional group that can participate in numerous reactions.</p>

Mal-amido-PEG8-Val-Gly is an ADC linker containing a maleimide moiety.

Boc-PEG2-Val-Cit-PAB-OH is an enzymatically cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized for attachment to reactive groups (such as PNP) to connect with a drug payload. The Boc protecting group can be removed with acid, revealing a primary amine that serves for coupling reactions to form an amide. The Val-Cit-PAB segment is cleaved by cellular proteases, facilitating the effective release of the payload inside the cell.

<p>PD-224378 is the lactam form of glycamine (β-isomer), produced through a Maillard reaction between pregabalin and lactose.</p>

<p>t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker, featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is susceptible to cleavage by cellular proteases and contains a free carboxylic acid that can couple with amines to form amides. The Boc group can be removed under acidic conditions to reveal a free primary amine, which is useful for various reactions, such as conjugation or reductive amination.</p>

Rivaroxabandiol is a metabolite of Rivaroxaban, which is a potent and selective direct inhibitor of coagulation factor Xa (FXa) with an IC50 of 0.7 nM and a Ki of 0.4 nM.

PSI-7410 is a metabolite of PSI-7851. PSI-7851 acts as an inhibitor of the HCV non-structural protein 5B (NS5B) and exhibits antiviral properties.

<p>4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO), produced through the N-dealkylation of BRO.</p>

(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1.

DOSPA hydrochloride is a cationic lipid utilized in the formation of lipid nanoparticles.

Benzyl N1-[PEG1-NHS]-N6-(t-Boc)-L-lysinate is a versatile ADC linker composed of a terminal benzyl group, a PEG unit, an NHS ester, and L-lysine protected with a t-Boc group. It is frequently utilized in research and development for bioconjugation and chemical modification.

NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker that features a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on the PAB component is suitable for attaching reactive groups (such as PNP) to facilitate binding with drug payloads. The primary amine is versatile for reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, or other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular cathepsins, allowing efficient payload delivery via an elimination mechanism through the PAB structure.

11-Mercaptoundecanoate-NHS is a lipid utilized in the synthesis of Linkers.

MC-Val-Ala-NHS ester is a cleavable ADC linker featuring maleimide and NHS ester groups. The Val-Ala linker is susceptible to cleavage by cathepsin B. The maleimide group can react with thiol groups, as can the MC component. The NHS ester reacts specifically and efficiently with amines (such as lysine residue side chains or aminosilane-coated surfaces) under neutral or mildly alkaline conditions, forming covalent bonds. Reagent grade, intended for research use only.

(S)-MCOPPB is the S-enantiomer of MCOPPB, an orally active selective agonist for the Nociceptin/Orphanin FQ-Receptor. It inhibits signal transduction in mouse brain NOP receptors and is utilized in anxiety disorder research.

<p>3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.</p>

<p>7-APB hydrochloride is a benzofuran compound and serves as a metabolite of 7-MAPB.</p>

BrAc-Val-Ala is an ADC linker, utilized for synthesizing antibody-drug conjugates (ADC) such as ABBV-969.

5-Carboxy-2′-deoxycytidine is a metabolite of Trifluridine.

<p>Propofolsulfate (sodium) is a metabolite of Propofol.</p>

Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB is an ADC linker characterized by its reactivity with interchain cysteine through maleimide and cleavability by β-glucuronidase. It is utilized in the synthesis of antibody-drug conjugates (ADCs), such as AZD0516.

EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.

(R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant. Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual antagonist of the cannabinoid CB1 receptor and inducible nitric oxide synthase (iNOS). It is beneficial in improving chronic kidney disease (CKD) caused by obesity.

<p>CIT-ALD is an aldehyde intermediate formed during the metabolism of Citalopram. It has potential applications in the research of neurological disorders.</p>

N-Methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine serves as a PEGn linker for antibody-drug conjugates (ADC).

Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.