Unter den Marken unserer mehr als 25 Partner sticht TargetMol hervor

<p>1-Pyrenamine is a polycyclic aromatic hydrocarbon (PAH) derivative commonly used as a catalyst carrier in methanol batteries</p>

<p>3-Hydroxy-4-methylbenzoic acid is a benzoic acid derivative widely used in biochemical experiments and drug synthesis research.</p>

<p>Butyramide is a fatty amide widely used in biochemical experiments and drug synthesis research.</p>

<p>2-Methyl-2-hexanol is a branched-chain fatty alcohol and tertiary alcohol compound widely used in biochemical experiments and drug synthesis research.</p>

<p>Lactic acid Lithium is a compound of lithium salt with lactic acid, which can be used for related research in the life sciences.</p>

<p>N-Caproicacid sodium is a highly pure biochemical reagent that acts as an agonist for Hydroxycarboxylic acid receptor 2 (EC50=113 μM).</p>

<p>DL-Ornithine hydrochloride is the hydrochloride salt form of DL-ornithine. It can serve as a potent supplement, influencing the secretion of anabolic hormones, fuel supply during exercise, stress-related mental performance, and preventing exercise-induced muscle damage.</p>

<p>4-Hydroxyclonidine is a metabolite of Clonidine. It is equally effective as Clonidine in displacing labeled Clonidine from antibodies.</p>

<p>DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker where Val-Cit is specifically cleaved by Cathepsin B. The PNP group can be substituted by amine-containing payloads, and DBCO undergoes click chemistry reactions with azide molecules.</p>

<p>Mal-Amide-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).</p>

<p>C14-490 is an ionizable cationic lipid (pKa= 5.94) utilized in the synthesis of lipid nanoparticles (LNPs). These LNPs serve as a platform for subsequent gene editing studies in hematopoietic stem cells (HSCs) in utero. C14-490 LNPs encapsulate SpCas9 mRNA and TTR sgRNA, employing an optimized B5 formulation parameter, and are further enhanced by the surface attachment of CD45 antibody F(ab’)2 fragments to create Systemically Targeted Editing Mechanism LNPs (STEM LNPs).</p>

<p>Fmoc-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized to attach reactive groups (e.g., PNP) for drug payload conjugation. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases, enabling efficient payload release into cells.</p>

<p>OSI-413 (free base) (CP 373413) is the primary metabolite of Erlotinib. Erlotinib (CP-358774) acts as a direct EGFR tyrosine kinase inhibitor with an IC50 of 2 nM against human EGFR.</p>

<p>Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker comprising a maleimide group, a PEG spacer, a Val-Cit dipeptide, PAB, and a PNP carbonate. The maleimide serves as a thiol-specific covalent connector for labeling cysteine residues in proteins, whereas the PNP group acts as a highly reactive leaving group. The Val-Cit linker is cleaved by cytoplasmic peptidases.</p>

<p>Mc-d-Val-d-Cit-PAB-PNP is a cleavable (cleavable) ADC linker employed in the synthesis of antibody-drug conjugates (ADCs).</p>

<p>Mal-amide-PEG8-Val-Cit-PAB-OH is a cleavable ADC linker, featuring a maleimide group, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB moiety. The maleimide group allows covalent bonding to free thiols on cysteine residues of proteins. The Val-Cit dipeptide is cleaved intracellularly by cathepsins to facilitate payload delivery via the PAB structure.</p>

<p>Fmoc-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker that features a Boc-protected amine, hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on the PAB can be used for conjugating reactive groups (e.g., PNP) to attach a payload. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases to efficiently release the payload inside cells.</p>

<p>Buspirone N-oxide (Bu N-oxide) is a metabolite of Buspirone. Buspirone is an orally active 5-HT1A receptor agonist and a dopamine D2 (dopamine D2) autoreceptor antagonist. It is an anxiolytic agent used for research in generalized anxiety disorder.</p>

<p>7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone. Risperidone acts as a 5-HT2 receptor blocker, an inhibitor of P-glycoprotein (P-Glycoprotein), and an antagonist of the dopamine D2 receptor.</p>

<p>NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC (antibody-drug conjugate) linker characterized by a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on PAB facilitates conjugation with reactive groups like PNP, enabling attachment to drug payloads. The primary amine readily participates in various reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, and other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular proteases, allowing efficient payload delivery through an elimination mechanism within the PAB structure.</p>