CAS 1009298-09-2

5-[2,4-Bis[(3S)-3-metil-4-morfolinil]pirido[2,3-d]pirimidin-7-il]-2-metoxibencenometanol

Descripción:

5-[2,4-Bis[(3S)-3-metil-4-morfolinil]pirido[2,3-d]pirimidin-7-il]-2-metoxibencenometanol, con número CAS 1009298-09-2, es un compuesto orgánico complejo caracterizado por su estructura de múltiples anillos, que incluye un núcleo de pirido-pirimidina y un grupo benceno sustituido por metoxi. Este compuesto presenta un grupo morfolina, que contribuye a su potencial actividad biológica, particularmente en química medicinal. La presencia de múltiples grupos funcionales sugiere que puede exhibir diversas reactividades químicas y propiedades de solubilidad. Su estereoquímica, indicada por la configuración (3S), implica disposiciones espaciales específicas que podrían influir en su interacción con objetivos biológicos. Las posibles aplicaciones del compuesto pueden incluir roles como agente farmacéutico, dado sus características estructurales que a menudo se asocian con moléculas bioactivas. Sin embargo, serían necesarios estudios detallados sobre su farmacocinética, toxicidad y eficacia para comprender completamente sus características y posibles usos en contextos terapéuticos.

Fórmula: C₂₅H₃₁N₅O₄

InChI: InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1

Clave InChI: InChIKey=KVLFRAWTRWDEDF-IRXDYDNUSA-N

SMILES: C[C@@H]1N(C=2C3=C(N=C(N2)N4[C@@H](C)COCC4)N=C(C=C3)C5=CC(CO)=C(OC)C=C5)CCOC1

Sinónimos:

• 5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
• Azd 8055
• Azd8055
• Benzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-
• Ccg 168
• Lm1148
• Nvp-Ccg 168
• [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol AZD 8055
• AZD 8055 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
• (5-{2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol
• AZD8055,AZD-8055
• AZD8055, >=98%
• {5-[2,4-Bis-(3-methyl-morpholin-4-yl)-pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-phenyl}-methanol
• AZD-8055 USP/EP/BP
• [5-[2,4-Bis((3S)-3-MethylMorpholin-4-yl)pyrido[
• (5-{2,4-dichloropyrido[2,3-d]pyriMidin-7-yl}-2-Methoxyphenyl)Methyl 2,2-diMethylpropanoate
• AZD-8055; AZD8055; AZD 8055.
• Propanoic acid, 2,2-dimethyl-, [5-(2,4-dichloropyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl]methyl ester
• CS-1935

Benzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-

CAS: 1009298-09-2

Fórmula: C₂₅H₃₁N₅O₄

Pureza: 96%

Forma y color: Solid

Peso molecular: 465.5447

Ref: IN-DA000383

AZD-8055

CAS: 1009298-09-2

AZD-8055

Pureza: ≥95%

Peso molecular: 465.54g/mol

Ref: 54-BUP13178

Azd-8055

CAS: 1009298-09-2

Azd-8055

Pureza: 97%

Peso molecular: 465.54g/mol

Ref: 54-OR1024083

AZD-8055

CAS: 1009298-09-2

AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.

Fórmula: C₂₅H₃₁N₅O₄

Pureza: 98% - 99.69%

Forma y color: Solid

Peso molecular: 465.54

Ref: TM-T1859

AZD-8055

CAS: 1009298-09-2

Pureza: ≥ 95.0%

Forma y color: Yellow powder or solid

Ref: 7W-GW4102

AZD8055

Producto controlado

CAS: 1009298-09-2

Applications A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphorylation of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition. Dual mTORC1/C2 inhibitor
References Chresta, C.M. et al.: Cancer Res., 70, 288 (2010); Sini, P. et al. Autophagy., 6 (2010); Marshall, G. et al.: Biochem. Soc. Trans., 39, 456 (2011);

Fórmula: C₂₅H₃₁N₅O₄

Forma y color: Neat

Peso molecular: 465.54

Ref: TR-A808130

AZD 8055

CAS: 1009298-09-2

A selective and ATP-competitive inhibitor of mTOR kinase with an IC50 value of 0.8 nM. Inhibits growth of a range of tumor types in vivo and in vitro. Effective in preventing and treating endocrine-resistant breast cancer. Causes autophagy in H838 and A549 cells.

Fórmula: C₂₅H₃₁N₅O₄

Pureza: Min. 95%

Peso molecular: 465.54 g/mol

Ref: 3D-FA18068