CAS 101515-08-6

7-deaza-2'-desoxiguanosina 5'-trifosfato de litio

Descripción:

7-Deaza-2'-desoxiguanosina 5'-trifosfato de litio, a menudo abreviado como 7-deaza-dGTP, es un nucleótido modificado que sirve como sustrato en diversas aplicaciones bioquímicas, particularmente en biología molecular e investigación genética. Este compuesto se caracteriza por la ausencia de un átomo de nitrógeno en la posición 7 de la base de guanina, lo que altera sus propiedades de enlace de hidrógeno y mejora su estabilidad durante las reacciones enzimáticas. El grupo trifosfato proporciona la energía necesaria para la incorporación en cadenas de ácidos nucleicos, lo que lo hace útil en técnicas como PCR y secuenciación de ADN. La forma de sal de litio ayuda en la solubilidad y estabilidad en soluciones acuosas. 7-deaza-dGTP es particularmente valioso para estudiar interacciones de ácidos nucleicos y para sintetizar oligonucleótidos modificados, ya que puede ayudar a reducir la formación de estructuras secundarias y mejorar la fidelidad de la síntesis de ADN. En general, este compuesto es una herramienta importante en el campo de la química de ácidos nucleicos y la biología molecular.

Fórmula: C₁₁H₁₇N₄O₁₃P₃

InChI: InChI=1/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)/t6-,7+,8+/m0/s1

Sinónimos:

• 2'-Deoxy-7-deazaguanosine triphosphate
• 2'-Deoxy-7-deaza-GTP
• 7-Deaza-2'-deoxyguanosine triphosphate
• 7-Deaza-2'-dgtp
• C7-Gdtp
• 4H-Pyrrolo(2,3-d)pyrimidin-4-one, 2-amino-7-(2-deoxy-5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-erythro-pentofuranosyl)-1,7-dihydro-
• 2-amino-7-[2-deoxy-5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)-beta-D-erythro-pentofuranosyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

7-Deaza-2′-deoxyguanosine 5′-triphosphate lithium salt

CAS: 101515-08-6

Fórmula: C₁₁H₁₇N₄O₁₃P₃

Peso molecular: 506.19

Ref: 7W-GK7906

7-Deaza-2'-deoxyguanosine-5'-triphosphate lithium salt - 100mM aqueous solution

CAS: 101515-08-6

7-Deaza-2'-deoxyguanosine-5'-triphosphate lithium salt is a nucleoside analog that inhibits telomerase. It binds to the catalytic subunit of telomerase, which is an RNA-dependent DNA polymerase that synthesizes telomeres during DNA replication. This binding prevents the enzyme from extending the 3' end of the DNA strand, inhibiting cell proliferation and leading to apoptosis. Telomerase inhibition has been shown to have an inhibitory effect on insulin resistance in mice. 7-Deaza-2'-deoxyguanosine-5'-triphosphate lithium salt also inhibits protein kinases, but does not inhibit phosphatases or other enzymes.

Fórmula: C₁₁H₁₇N₄O₁₃P₃·xLi

Pureza: Min. 95%

Peso molecular: 506.19 g/mol

Ref: 3D-ND157323

7-Deaza-2′-deoxyguanosine 5′-triphosphate

CAS: 101515-08-6

7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 value of 11 μM [1].

Fórmula: C₁₁H₁₇N₄O₁₃P₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 506.19

Ref: TM-T83248

7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt - 10mM aqueous solution

CAS: 101515-08-6

7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt is a cytosolic small molecule that inhibits the activity of telomerase, an enzyme involved in the replication of chromosomes. It also has inhibitory effects on kinase domains and may be used to treat cancer. 7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt binds to human mitochondrial DNA and inhibits gene transcription by hybridizing with it. This results in the inhibition of dopamine production, which can be helpful for treating Parkinson's disease. 7-Deaza-2'-deoxyguanosine-5'-triphosphate sodium salt is structurally similar to 2'-deoxyadenosine 5'-triphosphate (dATP) and can be incorporated into DNA by phosphorylation to form a covalent bond that disrupts the dATP/ATP ratio. This causes cellular energy production to decrease and

Fórmula: C₁₁H₁₇N₄O₁₃P₃·xNa

Pureza: Min. 95%

Peso molecular: 506.19 g/mol

Ref: 3D-ND157324