CAS 102601-58-1

N-cbz-gly-gly-arg 7-amido-4-*metilcumarina hidro

Descripción:

N-Cbz-gly-gly-arg 7-amido-4-metilcumarina hidro, identificado por el número CAS 102601-58-1, es un compuesto sintético que se utiliza a menudo en la investigación bioquímica, particularmente en el estudio de enzimas proteolíticas. Este compuesto presenta un moiety de cumarina, que es conocido por sus propiedades fluorescentes, lo que lo hace valioso en varios ensayos y técnicas de imagen. La presencia del grupo N-Cbz (carbobenzyloxi) indica que es un derivado de aminoácido protegido, que se utiliza comúnmente para facilitar la síntesis de péptidos. La secuencia gly-gly-arg sugiere que es un sustrato peptídico, potencialmente útil para estudiar la especificidad y actividad de las proteasas. Su designación hidro implica que puede existir en una forma hidratada o estar involucrado en reacciones hidrolíticas. En general, las características estructurales únicas y los grupos funcionales de este compuesto lo convierten en una herramienta significativa en el campo de la bioquímica, particularmente para aplicaciones que involucran cinética enzimática y especificidad de sustrato.

Fórmula: C₂₈H₃₄ClN₇O₇

InChI: InChI=1/C28H33N7O7.ClH/c1-17-12-25(38)42-22-13-19(9-10-20(17)22)34-26(39)21(8-5-11-31-27(29)30)35-24(37)15-32-23(36)14-33-28(40)41-16-18-6-3-2-4-7-18;/h2-4,6-7,9-10,12-13,21H,5,8,11,14-16H2,1H3,(H,32,36)(H,33,40)(H,34,39)(H,35,37)(H4,29,30,31);1H

SMILES: Cc1cc(=O)oc2cc(ccc12)N=C(C(CCCNC(=N)N)N=C(CN=C(CN=C(O)OCc1ccccc1)O)O)O.Cl

Sinónimos:

• Z-Gly-Gly-Arg-AMC . HCl
• N-[(benzyloxy)carbonyl]glycylglycyl-N5-(diaminomethylidene)-N-(4-methyl-2-oxo-2H-chromen-7-yl)ornithinamide hydrochloride
• Z-Gly-Gly-Arg-7-Amino-4-Methylcoumarin

Z-Gly-Gly-Arg-AMC · HCl

CAS: 102601-58-1

Z-GGR-AMC has been used as substrate in a direct fluorometric assay of urokinase and tissue-type plasminogen activator as well as for assaying trypsin and thrombin.The substrate is used as thrombin substrate in the calibrated automated thrombogram (CAT), an automated test developed by Hemker et al., for determining hyper- and hypocoagulability. Z-GGR-AMC can also be used for determining the tryptic activity of proteasomes.

Fórmula: C₂₈H₃₃N₇O₇·HCl

Pureza: > 99%

Forma y color: White

Peso molecular: 616.07

Ref: 01-4002155

L-Argininamide, N-[(phenylmethoxy)carbonyl]glycylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, hydrochloride (1:1)

CAS: 102601-58-1

Fórmula: C₉H₁₀ClNO₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 215.6336

Ref: IN-DA0007VN

Z-Gly-Gly-Arg-AMC HCl

CAS: 102601-58-1

Z-Gly-Gly-Arg-AMC HCl

Peso molecular: 616.07g/mol

Ref: 54-BIBA1003

N-CBZ-Glycyl-glycyl-L-arginine 7-Amido-4-methylcoumarin Hydrochloride

CAS: 102601-58-1

Applications N-CBZ-Glycyl-glycyl-L-arginine 7-Amido-4-methylcoumarin Hydrochloride is a fluorogenic substrate for uPA (urokinase).
References Zimmerman, M., et al. Proc. Natl. Acad. Sci. USA 75, 750 (1978);

Fórmula: C₂₈H₃₃N₇O₇·HCl

Forma y color: Neat

Peso molecular: 579.60 + (36.46)

Ref: TR-C227058

Z-Gly-Gly-Arg-AMC·HCl

CAS: 102601-58-1

Z-Gly-Gly-Arg-AMC·HCl is a proteolytic enzyme that cleaves proteins at the carboxyl side of the amino acid arginine. It has been shown to have potential as a drug target and has been found to be active against carcinoma cell lines, but not normal cells. Z-Gly-Gly-Arg-AMC·HCl is activated by light and can be inhibited by natural compounds such as 2-aminoethoxydiphenyl borate. In addition, it specifically cleaves proteins at the carboxyl side of arginine residues, which makes it useful for studying protein degradation mechanisms in living cells and tissues.

Fórmula: C₂₈H₃₃N₇O₇·HCl

Pureza: Min. 98%

Forma y color: White Powder

Peso molecular: 616.07 g/mol

Ref: 3D-FG110492

Z-Glycyl-Glycyl-L-Arginine 7-Amido-4-Methylcoumarin Hydrochloride Salt extrapure, 95%

CAS: 102601-58-1

Fórmula: C₂₈H₃₃N₇O₇·HCl

Peso molecular: 616.07

Ref: SR-72998