CAS 103476-89-7

L-Leucinamida, N-acetil-L-leucil-N-[(1S)-4-[(aminoiminometil)amino]-1-formilbutil]-, sulfato (2:1)

Descripción:

L-Leucinamida, N-acetil-L-leucil-N-[(1S)-4-[(aminoiminometil)amino]-1-formilbutil]-, sulfato (2:1) es un compuesto orgánico complejo caracterizado por sus componentes estructurales, que incluyen un derivado de aminoácido (L-leucina) y un grupo sulfato. Este compuesto presenta una disposición única de grupos funcionales, incluyendo funcionalidades amida y acilo, que contribuyen a su actividad biológica y propiedades de solubilidad. La presencia del grupo sulfato mejora su carácter iónico, lo que puede influir en su interacción con sistemas biológicos y solubilidad en entornos acuosos. Como derivado de L-leucina, puede exhibir propiedades relacionadas con la síntesis de proteínas y el metabolismo. La estereoquímica del compuesto, particularmente la configuración (1S), indica disposiciones espaciales específicas que pueden afectar sus interacciones biológicas. En general, esta sustancia probablemente sea de interés en la investigación bioquímica, particularmente en estudios relacionados con la síntesis de péptidos, el diseño de fármacos y aplicaciones terapéuticas, aunque las actividades biológicas específicas y las propiedades farmacológicas requerirían una investigación adicional.

Fórmula: C₂₀H₃₈N₆O₄H₂O₄S

InChI: InChI=1S/C20H38N6O4.H2O4S/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;1-5(2,3)4/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H2,1,2,3,4)/t15-,16-,17-;/m0./s1

Clave InChI: InChIKey=IBDASEYBOOUHFZ-FRKSIBALSA-N

SMILES: [C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)(C(N[C@@H](CCCNC(=N)N)C=O)=O)CC(C)C.S(=O)(=O)(O)O

Sinónimos:

• (2S)-2-(acetylamino)-N-[(2S)-2-({4-[(diaminomethylidene)amino]-1-formylbutyl}amino)-4-methylpentanoyl]-4-methylpentanamide (non-preferred name)
• 2-(2-Acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methylvaleramide
• <span class="text-smallcaps">L</smallcap>-Leucinamide, N-acetyl-<smallcap>L</span>-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-, sulfate (2:1)
• <span class="text-smallcaps">L</smallcap>-Leucinamide, N-acetyl-<smallcap>L</span>-leucyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, (S)-, sulfate (2:1)
• Acetyl-L-leucyl-L-leucylargininal
• L-Leucinamide, N-acetyl-L-leucyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-
• Leupeptin Ac-LL
• Leupeptin Hemisulfate From Microbial*Source
• Leupeptin hemisulfate
• N-Acetyl-L-leucyl-L-leucyl-L-argininal
• N-acetyl-L-leucyl-N-{(2S)-5-[(diaminomethylidene)amino]-1-oxopentan-2-yl}-L-leucinamide
• Nk-381
• Valeramide, 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methyl-
• L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-, sulfate (2:1)

Leupeptin

CAS: 103476-89-7

A reversible compeptitive protease inhibitor, which was shown to inhibit cathepsins B, H, L, and S, calpain and trypsin. Ac-LLR-CHO inhibits the trypsin-like activity of the proteasome endopeptidase complex. CAS Number (hemisulfate): 103476-89-7.

Fórmula: C₂₀H₃₈N₆O₄·H₂SO₄

Pureza: 97.8380%

Forma y color: White

Peso molecular: 951.2

Ref: 01-4013467

Leupeptin

CAS: 103476-89-7

Fórmula: C₄₀H₇₈N₁₂O₁₂S

Pureza: 97%

Forma y color: Solid

Peso molecular: 951.1855

Ref: IN-DA00ILJA

Leupeptin Hemisulfate

CAS: 103476-89-7

Leupeptin Hemisulfate

Pureza: ≥90%

Peso molecular: 475.59g/mol

Ref: 54-BUP13431

Leupeptin hemisulphate

CAS: 103476-89-7

Leupeptin hemisulphate

Fórmula: C₂₀H₃₈N₆O₄·H₂SO₄

Pureza: >90%

Forma y color: white to off white powder

Peso molecular: 951.18552g/mol

Ref: 54-BIMI2183

Leupeptin Hemisulfate

CAS: 103476-89-7

Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities.

Fórmula: C₂₀H₃₈N₆O₄H₂SO₄

Pureza: 90% - ≥98%

Forma y color: White Solid

Peso molecular: 475.59

Ref: TM-T6564

Leupeptin Hemisulfate

CAS: 103476-89-7

Fórmula: C₂₀H₃₈N₆O₄H₂O₄S

Peso molecular: 426.56 1/2*98.07

Ref: 4Z-L-175001

Leupeptin hemisulfate

CAS: 103476-89-7

Fórmula: C₂₀H₃₈N₆O₄·5H₂SO₄

Pureza: ≥ 95%

Forma y color: White to off-white powder

Peso molecular: 475.59

Ref: 7W-GE7125

Leupeptin hemisulfate anhydrous

CAS: 103476-89-7

Leupeptin is a protease inhibitor that inhibits the activity of proteases in cells. It has been shown to inhibit transcriptional regulation and apoptosis pathway, as well as possessing anti-inflammatory properties. Leupeptin has been shown to have inhibitory properties against a variety of proteases, including group P2 metalloproteases, cathepsin D, and proteinase 3. This drug has also been shown to prevent neuronal death in experimental models by inhibiting cell lysis. Leupeptin binds to the active site of the enzyme by forming hydrogen bonds with conserved amino acid residues and steric interactions with nearby amino acid residues. The redox potentials of leupeptin are not known, but it is assumed that they are low enough for its antioxidant properties to be effective.

Fórmula: C₂₀H₃₈N₆O₄H₂SO

Pureza: Min. 90 Area-%

Peso molecular: 475.6 g/mol

Ref: 3D-ILP-4041

Leupeptin hemisulfate anhydrous (vial)

CAS: 103476-89-7

Leupeptin is an ion channel blocker that belongs to the group of protease inhibitors. It blocks the passage of ions across cell membranes by binding to the active site of a variety of enzymes in the membrane. Leupeptin is used as a research tool for studying protein interactions, and can be used for antibody production. Leupeptin is also useful in cell biology studies, because it inhibits the activation of many proteins involved in signal transduction and cell division.

Fórmula: C₂₀H₃₈N₆O₄

Pureza: Min. 95%

Peso molecular: 426.55 g/mol

Ref: 3D-ILP-4041-V

Leupeptin hemisulfate

CAS: 103476-89-7

Leupeptin is a protein inhibitor that binds to the ubiquitin ligases and inhibits their activity. It has been shown to inhibit the transcriptional regulation of gene expression, which is important in cancer, chronic oral administration, and experimental models. Leupeptin also blocks the binding of proteins to DNA in cell culture and animal models. This leads to decreased production of fatty acids, which are needed for cellular growth and function. Leupeptin also has an anti-depressant effect by blocking the transcriptional regulation of gene expression for serotonin receptors.

Fórmula: C₂₀H₃₈N₆O₄•(H₂SO₄)₀

Pureza: Min. 90.0 Area-%

Forma y color: White Powder

Peso molecular: 475.59 g/mol

Ref: 3D-FL29627