CAS 104344-23-2

Fumarato de bisoprolol

Descripción:

Fumarato de bisoprolol es un bloqueador selectivo del receptor adrenérgico beta-1 que se utiliza principalmente en el manejo de la hipertensión y la insuficiencia cardíaca. Es un polvo cristalino blanco a blanco amarillento que es soluble en agua y metanol, pero menos soluble en disolventes orgánicos como el cloroformo y el éter. La sustancia se caracteriza por su capacidad para reducir la frecuencia cardíaca y la contractilidad miocárdica, lo que la hace efectiva para disminuir la presión arterial y mejorar la función cardíaca. Fumarato de bisoprolol se administra típicamente por vía oral y es conocido por su vida media relativamente larga, lo que permite una dosificación una vez al día. La forma de sal de fumarato mejora su estabilidad y solubilidad, facilitando una mejor absorción en el tracto gastrointestinal. Al igual que otros beta-bloqueadores, puede tener efectos secundarios como fatiga, mareos y bradicardia, y debe usarse con precaución en pacientes con asma o ciertas condiciones cardiovasculares. En general, Fumarato de bisoprolol es un agente terapéutico importante en la medicina cardiovascular, contribuyendo a mejorar los resultados en pacientes con diversas condiciones relacionadas con el corazón.

Fórmula: C₁₈H₃₁NO₄C₄H₄O₄

InChI: InChI=1S/C18H31NO4.C4H4O4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

Clave InChI: InChIKey=RZPZLFIUFMNCLY-WLHGVMLRSA-N

SMILES: O(CC(CNC(C)C)O)C1=CC=C(COCCOC(C)C)C=C1.C(=C/C(O)=O)\C(O)=O

Sinónimos:

• (2R)-1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol
• 1-(4-((2-Isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate
• 1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (2:1) (salt)
• 1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (salt)
• 1-(Propan-2-Ylamino)-3-(4-{[2-(Propan-2-Yloxy)Ethoxy]Methyl}Phenoxy)Propan-2-Ol
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1)
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (2E)-2-butenedioate (2:1) (salt)
• 2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-, (E)-2-butenedioate (2:1) (salt)
• Bisoprolol Fumarate
• Bisoprolol fumerate
• Concor
• Detensiel
• Emcor
• Emd 33512
• Emvoncor
• Eurtadal
• Isoten
• Maintate
• Monocor
• Soprol

Bisoprolol Hemifumarate

CAS: 104344-23-2, 66722-44-9

Fórmula: C₁₈H₃₁NO₄C₄H₄O₄

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 383.49

Ref: 3B-B3994

Bisoprolol Fumarate 1.0 mg/ml in Methanol (as free base)

CAS: 104344-23-2

Forma y color: Single Solution

Ref: 61-AMP0460.08-01

Bisoprolol Fumarate

CAS: 104344-23-2

Forma y color: Neat

Ref: 61-FOR0460.08

BISOPROLOL FOR SYSTEM SUITABILITY CRS

CAS: 104344-23-2

BISOPROLOL FOR SYSTEM SUITABILITY CRS

Fórmula: C₄₀H₆₆N₂O₁₂

Forma y color: Added Added

Peso molecular: 766.9582

Ref: 41-Y0000813

Bisoprolol fumarate

CAS: 104344-23-2

Bisoprolol fumarate

Fórmula: (C₁₈H₃₁NO₄)₂C₄H₄O₄

Pureza: 99.7%

Forma y color: White

Peso molecular: 766.46158

Ref: 47-1058

BISOPROLOL FUMARATE CRS

CAS: 104344-23-2

BISOPROLOL FUMARATE CRS

Fórmula: C₄₀H₆₆N₂O₁₂

Forma y color: Added Added

Peso molecular: 766.9582

Ref: 41-Y0000812

BISOPROLOL FOR PEAK IDENTIFICATION CRS

CAS: 104344-23-2

BISOPROLOL FOR PEAK IDENTIFICATION CRS

Forma y color: Added Added

Ref: 41-Y0000877

Bisoprolol Fumarate

CAS: 104344-23-2

Aromatic drugs of amino-alcohols, other than those contg more than one kind of oxygen function, their ethers and esters; salts thereof, nesoi

Fórmula: (C₁₈H₃₁NO₄)₂·C₄H₄O₄

Forma y color: White Powder

Peso molecular: 650.45062

Ref: 45-1075757

Bisoprolol (hemifumarate)

CAS: 104344-23-2

Fórmula: C₄₀H₆₆N₂O₁₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 766.9582

Ref: IN-DA003271

Bisoprolol hemifumarate

CAS: 104344-23-2

Bisoprolol, a selective beta-1 adrenergic receptor antagonist, selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart,

Fórmula: C₂₀H₃₃NO₆

Pureza: 98.69% - 99.84%

Forma y color: White To Offf-White Powder

Peso molecular: 383.49

Ref: TM-T0143

Bisoprolol hemifumarate salt

CAS: 104344-23-2

Fórmula: C₁₈H₃₁NO₄₀·5C₄H₄O₄

Pureza: 98.0 - 102.0 %

Forma y color: White to almost white powder

Peso molecular: 383.49

Ref: 7W-GP0667

Bisoprolol Hemifumarate

CAS: 104344-23-2

Fórmula: C₁₈H₃₁NO₄·5C₄H₄O₄

Forma y color: White To Off-White Solid

Peso molecular: 325.45 0.5*116.07

Ref: 4Z-B-092

(±)-Bisoprolol-d7 Hemifumarate(iso-propyl-d7)

CAS: 104344-23-2

Pureza: 99 atom % D

Forma y color: White Solid

Peso molecular: 390.5

Ref: 3U-D7507

Bisoprolol fumarate

CAS: 104344-23-2

Fórmula: C₁₈H₃₁NO₄·C₄H₄O₄

Forma y color: Neat

Peso molecular: 766.9582

Ref: 04-C10654000

Bisoprolol Fumarate

CAS: 104344-23-2

Forma y color: Neat

Ref: 86-MM0460.08

Bisoprolol hemifumarate

Producto controlado

CAS: 104344-23-2

Bisoprolol hemifumarate is a selective beta-1 receptor blocker that has been used in the treatment of high blood pressure, heart failure, and other cardiovascular diseases. It is a prodrug that undergoes enzymatic hydrolysis to bisoprolol in the liver. Bisoprolol hemifumarate has been shown to be effective as an adjunctive therapy for patients with bowel disease and cardiac effects such as lowering blood pressure levels. This drug also has a positive effect on the heart by increasing the levels of natriuretic peptides and decreasing the level of atrial fibrillation (AF). Bisoprolol hemifumarate can be detected in human serum or plasma samples through an analytical method involving liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS), which can then be analyzed by multivariate logistic regression to control for confounding factors such as age, gender, ethnicity, alcohol intake, and smoking status.

Fórmula: C₁₈H₃₁NO₄•(C₄H₄O₄)₀

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 383.48 g/mol

Ref: 3D-FB18827

Bisoprolol hemifumarate - Bio-X ™

Producto controlado

CAS: 104344-23-2

Bisoprolol is a β1- adrenergic antagonist agent that is used to treat hypertension and prevent myocardial infarction. As adrenergic neurotransmitters activate β1-receptors it causes an increase in blood pressure and heart rate. By reducing contractility and the need for oxygen through competitive inhibition of β1-adrenergic receptors, bisoprolol reduces the cardiac workload.

Fórmula: C₁₈H₃₁NO₄C₄H₄O₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 383.48 g/mol

Ref: 3D-BB164256

Bisoprolol Hemifumarate

CAS: 104344-23-2

Applications A selective β-adrenergic blocker. Used as an antihypertensive.
References Tattersfield, A.E., et al.: Brit. J. Clin. Pharmacol., 18, 343 (1984), Kohli, R.S., et al.: Eur. Heart J., 6, 845 (1985), Zachariah, P.K., et al.: Clin. Ther., 15, 779 (1993),

Fórmula: C₁₈H₃₁NO₄·C₄H₄O₄

Forma y color: Neat

Peso molecular: 766.9582

Ref: TR-B510500

Bisoprolol for peak identification CRS

CAS: 104344-23-2

Ref: ST-EA-Y0000877

Bisoprolol for system suitability CRS

CAS: 104344-23-2

Ref: ST-EA-Y0000813