CAS 105979-17-7

Benidipino

Descripción:

Benidipino es un bloqueador de canales de calcio que se utiliza principalmente en el tratamiento de la hipertensión y la angina de pecho. Pertenece a la clase de antagonistas del calcio dihidropiridínicos, que funcionan inhibiendo la entrada de iones de calcio a través de los canales de calcio tipo L en el músculo liso vascular y el tejido cardíaco, lo que conduce a la vasodilatación y a una reducción de la carga cardíaca. Benidipino exhibe un mecanismo de acción dual único, ya que bloquea tanto los canales de calcio tipo L como los tipo T, mejorando su eficacia en la reducción de la presión arterial. La sustancia se caracteriza por su lipofilia, lo que contribuye a su capacidad para penetrar eficazmente en las membranas celulares. Se administra típicamente por vía oral y tiene una vida media relativamente larga, lo que permite una dosificación una vez al día. Los efectos secundarios comunes pueden incluir mareos, dolor de cabeza y edema periférico, aunque generalmente es bien tolerado. Al igual que con otros medicamentos de su clase, se recomienda precaución en pacientes con ciertas condiciones cardiovasculares o aquellos que toman otros agentes antihipertensivos. En general, Benidipino representa una opción valiosa en el manejo de enfermedades cardiovasculares.

Fórmula: C₂₈H₃₂ClN₃O₆

InChI: InChI=1/C28H31N3O6/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3/t23-,26-/m1/s1

Clave InChI: InChIKey=QZVNQOLPLYWLHQ-MKNUCDGGNA-N

SMILES: C(O[C@H]1CN(CC2=CC=CC=C2)CCC1)(=O)C=3[C@@H](C(C(OC)=O)=C(C)NC3C)C4=CC(N(=O)=O)=CC=C4

Sinónimos:

• (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• (3R)-1-benzylpiperidin-3-yl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride (1:1)
• (3R)-1-benzylpiperidin-3-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, (4R)-rel-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, (4R)-rel-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, (R*,R*)-
• BND
• Benidipine Hcl
• Capadipine
• Nacadipine
• (±)-Benidipine
• Benidipine
• (R^<*>^，R^<*>^)-(±)-2，6-dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl(R^<*>^)-1-BenzyI-3-piperidylester
• BENIDIPINE HYDROCHLORIDE
• (4R)-2,6-Dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester
• CONIEL
• (+/-)-(R*)-3-((R*)-1-Benzyl-3-piperidyl) methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• (4R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R)-1-benzylpiperidin-3-yl] ester

Benidipine

CAS: 105979-17-7

Fórmula: C₂₈H₃₁N₃O₆

Peso molecular: 505.56

Ref: 7W-GP5445

Benidipine Hydrochloride

CAS: 105979-17-7, 91599-74-5

Fórmula: C₂₈H₃₁N₃O₆·HCl

Pureza: >98.0%(T)(HPLC)

Forma y color: Light yellow to Yellow to Orange powder to crystal

Peso molecular: 542.03

Ref: 3B-B5629

Benidipine

CAS: 105979-17-7

Benidipine: potent oral calcium blocker, boosts nitric oxide synthase, enhances coronary flow, protects heart cells post-ischemia.

Fórmula: C₂₈H₃₁N₃O₆

Forma y color: Solid

Peso molecular: 505.56

Ref: TM-T63452

Benidipine

CAS: 105979-17-7

Benidipine is a calcium channel blocker that inhibits the flow of calcium ions into cardiac and smooth muscle cells, which decreases the rate of these cells' contractions. Benidipine also has been shown to have a protective effect on the heart by preventing injury from coronary artery disease and other cardiovascular diseases. In addition, benidipine is not broken down in the liver and has a low risk of drug interactions. Benidipine has been found to be effective in reducing blood pressure in patients with chronic renal failure, although it may cause tubulointerstitial injury. The effects of benidipine are thought to be due to its ability to inhibit the release of growth factor-β1 from human polymorphonuclear leukocytes (PMNLs) and inhibit the proliferation of HL-60 cells.

Pureza: Min. 95%

Ref: 3D-FB176235

Benidipine 5-(1-Benzylpiperidin-3-yl)-d10

Producto controlado

CAS: 105979-17-7

Fórmula: C₃₉D₁₀H₃₄N₄O₆

Forma y color: Neat

Peso molecular: 674.851

Ref: TR-B157507