CAS 106128-98-7

AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY-OH

Descripción:

La sustancia química con el nombre "AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY-OH" y el número CAS "106128-98-7" es un péptido sintético compuesto por una secuencia de aminoácidos. Este péptido presenta una variedad de grupos funcionales característicos de los aminoácidos, incluidos grupos amino, ácidos carboxílicos e hidroxilos, que contribuyen a sus propiedades bioquímicas. La presencia de múltiples cadenas laterales polares y cargadas sugiere que este péptido puede exhibir características hidrofílicas, lo que podría influir en su solubilidad en entornos acuosos. La secuencia incluye aminoácidos esenciales como la lisina y la arginina, que son conocidos por sus roles en las interacciones proteicas y la señalización celular. Además, la acetilación en el N-terminal (indicada por "AC") puede mejorar su estabilidad y biodisponibilidad. Péptidos como este a menudo se estudian por sus posibles aplicaciones en farmacéutica, biotecnología y como herramientas de investigación para comprender las interacciones y funciones de las proteínas. En general, las características y el comportamiento específicos de este péptido dependerían de su conformación estructural y del contexto de su uso.

Fórmula: C₅₂H₈₈N₂₂O₁₇

Sinónimos:

• Myelin Basic Protein (1-11) (Guinea Pig, Horse, Porcine, Rabbit, Rat)
• Myelin Basic Protein (135-145), Human
• Ac-Mbp (Human, Porcine, Rat 1-11)
• Ac-Asqkrpsqrhg
• Acetyl-Golli-Mbp1 Hog7 (135-145) (Human)
• Acetyl-Myelin A1 Protein (135-145) (Human)
• Acetyl-Myelin Basic Protein (135-145) (Human)
• MBP (1-11), guinea pig, porcine, rabbit, rat, Myelin Basic Protein (135-145), human
• Acetyl-Golli-MBP1 HOG7 (135-145) (huMan), Acetyl-MBP (135-145) (huMan), Acetyl-Myelin A1 Protein (135-145) (huMan), Myelin Basic Protein (1-11) (guinea pig, horse, porcine, rabbit, rat)
• Glycine, N-acetyl-L-alanyl-L-seryl-L-glutaminyl-L-lysyl-L-arginyl-L-prolyl-L-seryl-L-glutaminyl-L-arginyl-L-histidyl-
• AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY
• AC-ALA-SER-GLN-LYS-ARG-PRO-SER-GLN-ARG-HIS-GLY-OH
• MBP (1-11), GUINEA PIG, PORCINE, RABBIT, RAT
• Acetyl-Myelin Basic Protein (135-145)) (hu
• 235:PN:WO2010033207 SEQID:291 claimed protein
• ACETYL-MBP (135-145) (HUMAN)
• MBP (1-11) HUMAN

Acetyl-Myelin Basic Protein (Human, Porcine, Rat, 1-11)

CAS: 106128-98-7

The myelin sheath which is located in both the Central Nervous System (CNS) and the Peripheral Nervous System is crucial for neural insulation and the salutatory conduction of nerve impulses. When this myelin sheath is destroyed neurodegeneration and conduction failure occur. This can be observed in demyelinating diseases in the CNS such as: acute disseminated encephalomyelitis and multiple sclerosis and within the PNS: Guillain–Barré syndrome and Charcot–Marie–Tooth disease.
Myelin Basic Protein (MBP) from which this product is derived is the second most abundant protein in myelin. It has been found to be an intrinsically disordered protein and depending on the environmental conditions it can change its conformation. It also folds into ⍺-helical structures which allow MBP to bind tightly to lipid bilayer surfaces. MBP also interacts with other proteins, namely cytoskeletal proteins and calmodulin and may be involved in signalling pathways.
Although more research needs to be carried out, it is thought that MBP significantly contributes to the pathogenesis of multiple sclerosis. As MBP is an autoantigen it can be recognized and cleaved by autoantibodies and is a substrate for the immunoproteasome. Additional research has found that post-translational modifications of MBP such as the removal of arginine are increased in and may be involved in the pathogenesis of multiple sclerosis. Therefore this protein derived from MBP can be used to mimic Neurodegenerative disease phenotypes in research and animal models.

Fórmula: C₅₂H₈₈N₂₂O₁₇

Pureza: Min. 95%

Peso molecular: 1,293.42 g/mol

Ref: 3D-PMB-3658-PI

MBP (1-11), human

CAS: 106128-98-7

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Fórmula: C₅₂H₈₈N₂₂O₁₇

Peso molecular: 1,293.42 g/mol

Ref: 3D-PP50289