CAS 107316-88-1

Desmetilzeylasteral

Descripción:

Desmetilzeylasteral, con el número CAS 107316-88-1, es un compuesto químico que pertenece a la clase de los esteroides, que son un subgrupo de los esteroides. Se caracteriza por su compleja estructura policíclica, que incluye múltiples anillos fusionados típicos de los compuestos esteroides. Esta sustancia se deriva principalmente de fuentes naturales, a menudo aislada de materiales vegetales, y es conocida por sus potenciales actividades biológicas, incluyendo propiedades antiinflamatorias y antioxidantes. Desmetilzeylasteral también puede exhibir efectos sobre el metabolismo lipídico y ha sido estudiada por sus posibles aplicaciones terapéuticas. Sus características de solubilidad indican típicamente que es más soluble en disolventes orgánicos que en agua, lo cual es común para muchos esteroides. La estabilidad y reactividad del compuesto pueden verse influenciadas por sus grupos funcionales y la presencia de enlaces dobles en su estructura. Al igual que muchos esteroides, puede desempeñar un papel en los procesos celulares y la dinámica de las membranas, lo que lo hace de interés tanto en la investigación farmacológica como bioquímica.

Fórmula: C₂₉H₃₆O₆

InChI: InChI=1S/C29H36O6/c1-25-6-7-26(2,24(34)35)14-21(25)29(5)11-9-27(3)17-12-19(32)23(33)16(15-30)22(17)18(31)13-20(27)28(29,4)10-8-25/h12-13,15,21,32-33H,6-11,14H2,1-5H3,(H,34,35)/t21-,25-,26-,27+,28-,29+/m1/s1

Clave InChI: InChIKey=ZDZSFWLPCFRASW-CPISFEQASA-N

SMILES: C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@](C(O)=O)(C)C3)[H])CC[C@]4(C)C2=CC(=O)C=5C4=CC(O)=C(O)C5C=O

Sinónimos:

• TZ 93
• Demethylzeylasteral
• (9β,13α,14β,20α)-2,3-Dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid
• 24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-6,23-dioxo-, (9β,13α,14β,20α)-
• D:A-Friedo-24-noroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-6,23-dioxo-, (20α)-

Demethylzeylasteral

CAS: 107316-88-1

Fórmula: C₂₉H₃₆O₆

Pureza: 98%

Forma y color: Solid

Peso molecular: 480.5925

Ref: IN-DA008Y1T

Demethylzeylasteral

CAS: 107316-88-1

Demethylzeylasteral

Pureza: ≥98%

Peso molecular: 480.59g/mol

Ref: 54-BUP06528

Demethylzeylasteral

CAS: 107316-88-1

Fórmula: C₂₉H₃₆O₆

Peso molecular: 480.60

Ref: 7W-GY6323

Demethylzeylasteral (T-96)

CAS: 107316-88-1

Demethylzeylasteral (T-96)

Pureza: 95%

Peso molecular: 480.59g/mol

Ref: 54-OR1024117

Demethylzeylasteral

CAS: 107316-88-1

Demethylzeylasteral exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A6 and 2B7, and the inhibition kinetic parameters (Ki) are calculated to be 0.6 uM and 17.3 uM for UGT1A6 and UGT2B7, respectively. Demethylzeylasteral has antimicrobial, strong immunosuppressive, and antifertility activities; it concentration-dependently and in a partially reversible manner can inhibit the Ca(2+) current in spermatogenic cells with an IC(50) of 8.8 microg/ml, and it also can inhibit significantly the sperm acrosome reaction initiated by progesterone.

Fórmula: C₂₉H₃₆O₆

Pureza: 95%~99%

Peso molecular: 480.601

Ref: BP-BP0477

Demethylzeylasteral

CAS: 107316-88-1

Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities.

Fórmula: C₂₉H₃₆O₆

Pureza: 98.74% - 99.82%

Forma y color: Solid

Peso molecular: 480.59

Ref: TM-T3418

Demethylzeylasteral

CAS: 107316-88-1

Carboxylic acid with additional oxygen functions

Fórmula: C₂₉H₃₆O₆

Pureza: ≥ 90.0 % (HPLC)

Forma y color: Powder

Peso molecular: 480.6

Ref: 5G-83493

Demethylzeylasteral

Producto controlado

CAS: 107316-88-1

Applications Demethylzeylasteral is a natural product as new inhibitor to block the Bcl-XL-Bid interaction. Also, it is an immunosuppressive monomer isolated from the root xylem of Tripterygium wilfordii. It exhibits inhibition towards the glucuronidation elimination reaction of SN-38.
References Xu, M., et al.: Anal. Chem., 88, 8050-8057 (2016); An, H., et al.: Cell Biochem. Biophys., 73, 673-679 (2015)

Fórmula: C₂₉H₃₆O₆

Forma y color: Neat

Peso molecular: 480.59

Ref: TR-D231408

Demethylzeylasteral

Producto controlado

CAS: 107316-88-1

Demethylzeylasteral is a drug that has been shown to have significant cytotoxicity against du-145 cells and may be used as an experimental model for autoimmune diseases. The drug has shown clinical relevance in vitro assays, where it was found to inhibit the proliferation of glomerular cells and induce mitochondrial membrane potential loss. Demethylzeylasteral also appears to have significant interactions with other drugs, such as lc-ms/ms method. This drug is a chinese herb that has been shown to increase autophagy and decrease metabolic disorders in animal models.

Fórmula: C₂₉H₃₆O₆

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 480.59 g/mol

Ref: 3D-FD73925