CAS 107452-89-1

omega-conotoxina mviia

Descripción:

omega-conotoxina mviia es un péptido derivado del veneno del caracol cono marino, Conus magus. Se clasifica como una neurotoxina y es conocido por su potente capacidad para bloquear selectivamente los canales de calcio dependientes de voltaje de tipo N (VGCC), que desempeñan un papel crucial en la liberación de neurotransmisores y la señalización del dolor. Esta característica hace de omega-conotoxina mviia un tema de interés en la investigación sobre el manejo del dolor y aplicaciones terapéuticas potenciales. El péptido consta de 25 aminoácidos y presenta una estructura única estabilizada por enlaces disulfuro, lo que contribuye a su estabilidad y especificidad. Su mecanismo de acción implica la unión a los canales de calcio, inhibiendo la entrada de calcio y, por lo tanto, reduciendo la liberación de neurotransmisores, lo que puede aliviar las sensaciones de dolor. omega-conotoxina mviia ha sido estudiado por su posible uso en el tratamiento de condiciones de dolor crónico y tiene implicaciones en la investigación en neurociencia, particularmente en la comprensión de las vías del dolor y la transmisión sináptica. Como compuesto de investigación, a menudo se utiliza en estudios farmacológicos para explorar sus efectos sobre la actividad neuronal y la modulación del dolor.

Fórmula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

InChI: InChI=1/C102H172N36O32S7/c1-50(2)34-63-91(161)127-62(26-33-171-5)90(160)129-64(35-53-22-24-54(143)25-23-53)92(162)130-65(36-78(148)149)93(163)135-72-48-175-173-45-69(80(108)150)133-86(156)58(18-8-12-29-105)121-76(146)39-117-85(155)66(41-139)131-88(158)61(21-15-32-114-102(111)112)126-96(166)70-46-176-177-47-71(97(167)132-68(43-141)95(165)125-60(87(157)128-63)20-14-31-113-101(109)110)134-89(159)59(19-9-13-30-106)123-81(151)51(3)119-74(144)37-115-83(153)56(16-6-10-27-103)120-75(145)38-116-84(154)57(17-7-11-28-104)124-82(152)55(107)44-172-174-49-73(137-98(72)168)99(169)138-79(52(4)142)100(170)118-40-77(147)122-67(42-140)94(164)136-70/h22-25,50-52,55-73,79,139-143H,6-21,26-49,103-107H2,1-5H3,(H2,108,150)(H,115,153)(H,116,154)(H,117,155)(H,118,170)(H,119,144)(H,120,145)(H,121,146)(H,122,147)(H,123,151)(H,124,152)(H,125,165)(H,126,166)(H,127,161)(H,128,157)(H,129,160)(H,130,162)(H,131,158)(H,132,167)(H,133,156)(H,134,159)(H,135,163)(H,136,164)(H,137,168)(H,138,169)(H,148,149)(H4,109,110,113)(H4,111,112,114)

SMILES: CC(C)CC1C(=NC(CCSC)C(=NC(Cc2ccc(cc2)O)C(=NC(CC(=O)O)C(=NC2CSSCC(C(=N)O)N=C(C(CCCCN)N=C(CN=C(C(CO)N=C(C(CCCNC(=N)N)N=C(C3CSSCC(C(=NC(CO)C(=NC(CCCNC(=N)N)C(=N1)O)O)O)N=C(C(CCCCN)N=C(C(C)N=C(CN=C(C(CCCCN)N=C(CN=C(C(CCCCN)N=C(C(CSSCC(C(=NC(C(C)O)C(=NCC(=NC(CO)C(=N3)O)O)O)O)N=C2O)N)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O

Sinónimos:

• Conotoxin MVIIA
• H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys20/ Cys15 and Cys25)
• Ziconotide
• Ziconotide Acetate

ω-Conotoxin MVIIA

CAS: 107452-89-1

ω-Conotoxin MVIIA, originally isolated from the venom of the fish-hunting cone snail Conus magus, is a blocker of voltage-sensitive Ca²⁺ channels in neurons. The peptide has been used to identify different Ca²⁺ channel subtypes in amphibian brain.

Fórmula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Pureza: ≥ 97%

Forma y color: White Powder

Peso molecular: 2639.17

Ref: 01-4025279

ω-Conotoxin MVIIA

CAS: 107452-89-1

Fórmula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Pureza: (HPLC) ≥ 97.0%

Forma y color: White powder

Peso molecular: 2639.13

Ref: 7W-GK7741

Ziconotide

CAS: 107452-89-1

Ziconotide: analgesic from cone snail for severe, chronic pain; synthetic ω-conotoxin.

Fórmula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Pureza: 98%

Forma y color: White Powder

Peso molecular: 2639.13

Ref: TM-TP1559

Ziconotide

CAS: 107452-89-1

Fórmula: C₁₀₂H₁₇₂N₃₆O₃₂S₇·C₂H₄O₂

Pureza: 95%~99%

Forma y color: White to Off-white Powder

Peso molecular: 2699.18

Ref: BP-BPPG070

Ziconotide Acetate

CAS: 107452-89-1

Fórmula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Peso molecular: 2639.20

Ref: 4Z-PZ-046001

Omega-Conotoxin MVIIA

CAS: 107452-89-1

Omega-conotoxin MVIIA is a peptide that is an activator of voltage-gated calcium channels. It is an inhibitor of the L-type calcium channel and can be used to study protein interactions in cell biology. Omega-conotoxin MVIIA has been shown to have binding affinity for the nicotinic acetylcholine receptor, which belongs to the class of ligand-gated ion channels. This toxin has also been used as a research tool in pharmacology and antibody production. Omega-conotoxin MVIIA has a molecular weight of 3,411 daltons, with purity greater than 95%. CAS No. 107452-89-1

Fórmula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Pureza: Min. 95%

Peso molecular: 2,639.1 g/mol

Ref: 3D-PCN-4289-V

Omega-Conotoxin MVIIA

Producto controlado

CAS: 107452-89-1

Omega-Conotoxin MVIIA is a neurotoxin that inhibits voltage-dependent calcium channels and has been shown to be effective against neuropathic pain, chronic pain, and inflammatory pain. The long-term efficacy of this drug is due to its ability to block cytosolic calcium, which leads to the activation of neurotrophic factors. Omega-Conotoxin MVIIA binds to specific protein targets and inhibits ion channel activity in neurons. This toxin can also inhibit the production of proinflammatory cytokines by blocking the activation of NF-κB through intracellular targets. Omega-Conotoxin MVIIA has been shown to have a wide range of therapeutic potentials, including as an analgesic for acute and chronic pain, as an anti-inflammatory agent, and as a neuroprotective agent for treating neuronal degeneration.

Fórmula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Pureza: Min. 95%

Peso molecular: 2,639.14 g/mol

Ref: 3D-FC110295