CAS 107724-20-9
:(+)-Eplerenona
Descripción:
(+)-Eplerenona es un esteroide sintético y un antagonista selectivo de la aldosterona, utilizado principalmente en el tratamiento de la hipertensión y la insuficiencia cardíaca. Se caracteriza por su capacidad para bloquear los efectos de la aldosterona, una hormona que regula los niveles de sodio y potasio en el cuerpo, promoviendo así la diuresis y reduciendo la presión arterial. El compuesto tiene una estructura molecular única que incluye un anillo de lactona y una estructura espiral, lo que contribuye a su especificidad y potencia. (+)-Eplerenona exhibe buena biodisponibilidad oral y se metaboliza principalmente en el hígado, con una vida media que permite una dosificación una vez al día. Su perfil farmacológico incluye un perfil de efectos secundarios favorable en comparación con otros diuréticos, con una menor incidencia de hiperpotasemia. Además, se ha demostrado que mejora los resultados en pacientes con insuficiencia cardíaca post-infarto de miocardio. En general, (+)-Eplerenona representa una opción terapéutica importante en la medicina cardiovascular, particularmente para pacientes con condiciones relacionadas con el exceso de aldosterona.
Fórmula:C24H30O6
InChI:InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
Clave InChI:InChIKey=JUKPWJGBANNWMW-VWBFHTRKSA-N
SMILES:C[C@@]12[C@]34[C@]([C@]5([C@](C)(C[C@]3(O4)[H])[C@@]6(CC5)CCC(=O)O6)[H])([C@H](C(OC)=O)CC1=CC(=O)CC2)[H]
Sinónimos:- Cgp 30083
- Epoxymexrenone
- Inspra
- Pregn-4-Ene-7,21-Dicarboxylic Acid 9,11-Epoxy-17-Hydroxy-3-Oxo Gamma-Lactone Methyl Ester
- Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α)-
- Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, methyl ester, (7α,11α,17α)-
- Sc 6110
- Sc 66110
- Selara
- Spiro[9,11-epoxy-9H-cyclopenta[a]phenanthrene-17(2H),2′(3′H)-furan], pregn-4-ene-7,21-dicarboxylic acid deriv.
- The Intermediates
- methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
- methyl (4aS,4bR,5aR,6aS,7S,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
- methyl (4aS,4bR,5aS,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate
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Eplerenone
CAS:Fórmula:C24H30O6Pureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:414.50EPLERENONE FOR PEAK IDENTIFICATION CRS
CAS:EPLERENONE FOR PEAK IDENTIFICATION CRSFórmula:C24H30O6Forma y color:PowderPeso molecular:414.4914EPLERENONE FOR SYSTEM SUITABILITY CRS
CAS:EPLERENONE FOR SYSTEM SUITABILITY CRSFórmula:C24H30O6Forma y color:PowderPeso molecular:414.4914Eplerenone
CAS:Adrenal cortical hormones and their derivatives nesoiFórmula:C24H30O6Forma y color:White Off-White Crystalline PowderPeso molecular:414.20424Eplerenone
CAS:<p>Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension.</p>Fórmula:C24H30O6Pureza:99.75% - ≥98%Forma y color:White SolidPeso molecular:414.49Eplerenone
CAS:Fórmula:C24H30O6Pureza:≥ 98.0%Forma y color:White to off-white powderPeso molecular:414.49Eplerenone-d3
CAS:Producto controlado<p>Applications Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.<br>References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),<br></p>Fórmula:C24H27D3O6Forma y color:NeatPeso molecular:417.51Eplerenone
CAS:<p>Applications Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.<br>References de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987), Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001), Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004), Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (2005),<br></p>Fórmula:C24H30O6Forma y color:NeatPeso molecular:414.49Eplerenone - Bio-X ™
CAS:<p>Eplerenone is a drug known as an aldosterone antagonist. It is a type of potassium-sparing diuretic that is used to treat chronic heart failure and high blood pressure, particularly for patients with resistant hypertension due to elevated aldosterone. It does this by blocking the activity of the enzyme that produces aldosterone, which increases levels of sodium and water in the body. This leads to a decrease in blood pressure.</p>Fórmula:C24H30O6Pureza:Min. 95%Forma y color:PowderPeso molecular:414.49 g/mol
