CAS 1092939-17-7

Jakafi

Descripción:

Jakafi, conocido genéricamente como ruxolitinib, es un inhibidor selectivo de las quinasas Janus (JAK1 y JAK2) y se utiliza principalmente en el tratamiento de ciertas neoplasias mieloproliferativas, como la policitemia vera y la mielofibrosis. Funciona modulando la respuesta inmune y reduciendo la inflamación al inhibir las vías de señalización de diversas citoquinas. El ruxolitinib se administra por vía oral y se caracteriza por su capacidad para mejorar los síntomas relacionados con estas condiciones, como la esplenomegalia y los síntomas constitucionales. La sustancia tiene una fórmula molecular que refleja su estructura compleja, que incluye un núcleo de pirrolo[2,3-d]pirimidina. Su farmacocinética indica una biodisponibilidad moderada, con un metabolismo que ocurre principalmente en el hígado a través de las enzimas del citocromo P450. Los efectos secundarios comunes pueden incluir anemia, trombocitopenia y un mayor riesgo de infecciones debido a sus propiedades inmunosupresoras. En general, Jakafi representa un avance significativo en las terapias dirigidas para trastornos hematológicos.

Fórmula: C₁₇H₁₈N₆·H₃PO₄

InChI: InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1

Clave InChI: InChIKey=JFMWPOCYMYGEDM-XFULWGLBSA-N

SMILES: [C@H](CC#N)(N1C=C(C2=C3C(=NC=N2)NC=C3)C=N1)C4CCCC4.P(=O)(O)(O)O

Sinónimos:

• (Betar)-Beta-Cyclopentyl-4-(7H-Pyrrolo(2,3-D)Pyrimidin-4-Yl)-1H-Pyrazole-1-Propanenitrile
• 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-, phosphate (1:1)
• INC 424 phosphate
• INCB 018424 phosphate
• Incb-018424
• Jakafi
• Jakavi
• R-Incb018424
• R-Ruxolitinib
• Ruxolitinib (INCB 018424)
• Ruxolitinib phosphate
• Ruxolitinib phosphate salt
• INC424
• INCB018424;INCB-018424;INCB 018424
• (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate
• Ruxolitinib phosphate(INCB018424)
• Beta-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(Betar)-1H-pyrazole-1-propanenitrile, phosphate
• (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
• INCB018424 PHOSPHATE;INCB 018424 PHOSPHATE;INCB-018424 PHOSPHATE;RUXOLITINIB
• phosphenoperoxoic acid compound with (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile and dihydrogen (1:1:1)
• (R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosph
• Ruxolitinib (INCB-18424) phosphate
• Ruxolitinib Phosphate (INC-424, INCB-18424, INCB-018424, Jakafi and Jakavi)
• (R)-3-(4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate
• INCB018424 (phosphate)
• Ruxolitinib phosphate ISO 9001：2015 REACH
• (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate
• Jakafi (ruxolitinib)
• INCB 018424(Ruxolitinib Phosphate)
• RUXOLITINIB(INCB018424) PHOSPHATE
• Ruxotinib phosphate
• 10-dimethoxyptercarpan
• (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphoric acid
• Ruxolitinib phosphate, >=98%
• (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazole-1-propanenitrile Phosphate

Ruxolitinib phosphate

CAS: 1092939-17-7

Ruxolitinib phosphate

Pureza: ≥98%

Peso molecular: 404.36g/mol

Ref: 54-BUP17785

Ruxolitinib Phosphate

CAS: 1092939-17-7

Fórmula: C₁₇H₁₈N₆·H₃O₄P

Forma y color: White To Off-White Solid

Peso molecular: 306.37 97.99

Ref: 4Z-R-093001

(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

CAS: 1092939-17-7

(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate

Pureza: 98%

Peso molecular: 404.36g/mol

Ref: 54-OR302722

Ruxolitinib Phosphate Salt

CAS: 1092939-17-7

Ruxolitinib Phosphate Salt

Fórmula: C₁₇H₁₈N₆·H₃O₄P

Pureza: >99%

Forma y color: white solid

Peso molecular: 404.36g/mol

Ref: 54-BIFK0028

Ruxolitinib phosphate

CAS: 1092939-17-7

Ruxolitinib phosphate (INCB18424 phosphate) is a JAK1/2 inhibitor with IC50 of 3.3 nM/2.8 nM. Cost-effective and quality-assured.

Fórmula: C₁₇H₂₁N₆O₄P

Pureza: 98% - >99.99%

Forma y color: Solid

Peso molecular: 404.36

Ref: TM-T3043

Ruxolitinib . phosphate salt

CAS: 1092939-17-7

Ref: 7W-GW4048

Ruxolitinib Phosphate

Producto controlado

CAS: 1092939-17-7

Applications The phosphate salt of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.
References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);

Fórmula: C₁₇H₁₈N₆·H₃O₄P

Forma y color: Off White Solid

Peso molecular: 404.36

Ref: TR-R702005

Ruxolitinib phosphate

CAS: 1092939-17-7

Pureza: 99%

Peso molecular: 404.367

Ref: 10-F979379

Ruxolitinib phosphate

Producto controlado

CAS: 1092939-17-7

Ruxolitinib is a janus tyrosine kinase inhibitor active specifically on sub-types JAK1 and JAK2 with IC50 values in the nanomolar range. JAK1 and JAK2 are kinases involved in the regulation of hematopoiesis. Clinically applied to the treatment of intermediate and high-risk myelofibrosis, ruxolitinib is usually well tolerated by patients.

Fórmula: C₁₇H₁₈N₆•H₃O₄P

Pureza: Min. 95%

Peso molecular: 404.36 g/mol

Ref: 3D-FR167906