CAS 109358-46-5

Boc-Leu-Arg-Arg-AMC . 2 HCl

Descripción:

Boc-Leu-Arg-Arg-AMC·2 HCl, también conocido como un sustrato peptídico, es un compuesto sintético comúnmente utilizado en investigación bioquímica, particularmente en estudios que involucran proteasas y actividad enzimática. El grupo "Boc" (tert-butiloxicarbonilo) sirve como un grupo protector para el aminoácido leucina (Leu), mientras que "Arg" denota residuos de arginina, que son conocidos por sus propiedades básicas y su participación en varios procesos biológicos. La parte "AMC" (7-amino-4-metilcumarina) actúa como un reportero fluorescente, permitiendo la detección de la escisión enzimática. La presencia de dos sales de clorhidrato (HCl) indica que el compuesto está en forma de sal, lo que puede mejorar su solubilidad en soluciones acuosas. Este compuesto se utiliza típicamente en ensayos para monitorear la actividad proteolítica, ya que la escisión del enlace peptídico libera el AMC fluorescente, permitiendo un análisis cuantitativo. Su estabilidad, solubilidad y propiedades fluorescentes lo convierten en una herramienta valiosa en biología molecular y bioquímica para estudiar la cinética enzimática y la especificidad del sustrato.

Boc-Leu-Arg-Arg-AMC · 2 HCl

CAS: 109358-46-5

Boc-LLR-AMC is a good substrate for the Kex2 endoprotease (kexin, previously known as proteinase yscF), a membrane-bound, calcium-dependent serine protease from yeast α-cells. Boc-LRR-AMC is also used for determining the trypsin-like activity of the proteasome.

Fórmula: C₃₃H₅₂N₁₀O₇·2HCl

Pureza: > 99%

Forma y color: White Powder

Peso molecular: 773.76

Ref: 01-4017087

Boc-LRR-AMC

CAS: 109358-46-5

Boc-LRR-AMC is a fluorogenic 26S/20S proteasome substrate that releases fluorescent AMC upon cleavage, aiding activity quantification.

Fórmula: C₃₃H₅₂N₁₀O₇

Forma y color: Solid

Peso molecular: 700.83

Ref: TM-T37011

Boc-Leu-Arg-Arg-AMC

CAS: 109358-46-5

Fórmula: C₃₃H₅₂N₁₀O₇·C₂H₄O₂

Pureza: ≥ 98.0%

Forma y color: White lyophilised powder

Peso molecular: 760.9

Ref: 7W-GL3169

Boc-Leu-Arg-Arg-AMC·2 HCl

Producto controlado

CAS: 109358-46-5

Fórmula: C₃₃H₅₂N₁₀O₇

Forma y color: Neat

Peso molecular: 700.829

Ref: TR-B015266

Boc-Leu-Arg-Arg-AMC dihydrochloride

CAS: 109358-46-5

Boc-Leu-Arg-Arg-AMC·2 HCl is a soybean trypsin inhibitor that has been used in the study of basic protein synthesis and cellular physiology. This inhibitor binds to the active site of soybean trypsin, preventing it from cleaving peptide bonds. The kinetic of this reaction was studied using Boc-Leu-Arg-Arg-AMC·2 HCl as a substrate and its inhibition by various concentrations of inhibitors. The inhibitory effect on the enzyme activity was measured by following the release of AMC fluorogenic substrate in vitro. Boc-Leu-Arg-Arg-AMC·2 HCl was found to be an effective inhibitor of melanoma antigen formation in vivo when injected into mice with melanoma xenografts. It also decreased tumor growth and increased survival rates in leukemic mice treated with platinum chemotherapy drugs or other pharmacological agents.

Fórmula: C₃₃H₅₂N₁₀O₇·2HCl

Pureza: Min. 95%

Peso molecular: 773.75 g/mol

Ref: 3D-FB110557

Boc-Leu-Arg-Arg-AMC

CAS: 109358-46-5

Boc-Leu-Arg-Arg-AMC is a synthetic, nonpeptide antagonist of the CGRP receptor. It has been shown to inhibit the binding of peptides to the CGRP receptor and is used as a research tool for studying the pharmacology and protein interactions of this receptor. Boc-Leu-Arg-Arg-AMC has been shown to stimulate ion channel activity in vitro. This compound also has an affinity for antibodies that are specific for CGRP receptors, which can be used as a ligand in immunoassays.

Fórmula: C₃₃H₅₂N₁₀O₇

Pureza: Min. 95%

Peso molecular: 700.83 g/mol

Ref: 3D-MLR-3140-V