CAS 1093861-60-9
:Afoxolaner
Descripción:
Afoxolaner es un insecticida y acaricida que pertenece a la clase de compuestos isoxazolinas, utilizado principalmente en medicina veterinaria para el tratamiento y prevención de infestaciones de pulgas y garrapatas en perros y gatos. Su mecanismo de acción implica la inhibición de los canales de cloruro activados por ácido gamma-aminobutírico (GABA) y glutamato, lo que lleva a la parálisis y muerte de los parásitos objetivo. Afoxolaner se caracteriza por su alta eficacia contra un amplio espectro de ectoparásitos, incluidas pulgas, garrapatas y ácaros, y se administra típicamente por vía oral en forma de tabletas masticables. El compuesto es conocido por sus efectos duraderos, proporcionando protección durante varias semanas después de la administración. Afoxolaner generalmente es bien tolerado en mascotas, con una baja incidencia de efectos adversos. Su perfil de seguridad, combinado con su efectividad, lo ha convertido en una opción popular entre los veterinarios para el manejo de infestaciones parasitarias. Al igual que con cualquier fármaco, es importante seguir las pautas de dosificación y consultar a un veterinario para un uso adecuado.
Fórmula:C26H17ClF9N3O3
InChI:InChI=1S/C26H17ClF9N3O3/c27-15-8-13(7-14(9-15)25(31,32)33)23(26(34,35)36)10-20(39-42-23)18-5-6-19(17-4-2-1-3-16(17)18)22(41)37-11-21(40)38-12-24(28,29)30/h1-9H,10-12H2,(H,37,41)(H,38,40)
Clave InChI:InChIKey=OXDDDHGGRFRLEE-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1(CC(=NO1)C=2C3=C(C(C(NCC(NCC(F)(F)F)=O)=O)=CC2)C=CC=C3)C4=CC(C(F)(F)F)=CC(Cl)=C4
Sinónimos:- 4-[5-(3-chloro-5-trifluoromethylphenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-naphthalene-1-carboxylic acid [(2,2,2-trifluoroethylcarbamoyl)-methyl]-amide
- 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-
- 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-
- 4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
- Afoxolaner
- Nexgard
- Avrana
- China biggest manufacturer,Afoxolaner,1093861-60-9
- 4-(5-(3-Chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-1-naphthamide
- afoxolaner-007
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Encontrado 12 productos.
4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
CAS:Fórmula:C26H17ClF9N3O3Pureza:98%Forma y color:SolidPeso molecular:625.8701Afoxolaner
CAS:<p>Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.</p>Fórmula:C26H17ClF9N3O3Pureza:99.1% - 99.38%Forma y color:SolidPeso molecular:625.87Afoxolaner (Standard)
CAS:Afoxolaner (Standard) is the standard substance of Afoxolaner, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.Fórmula:C26H17ClF9N3O3Peso molecular:625.87Afoxolaner 100 µg/mL in Acetonitrile
CAS:Producto controladoFórmula:C26H17ClF9N3O3Forma y color:Single SolutionPeso molecular:625.87Afoxolaner
CAS:Afoxolaner is a bicyclic heterocycle that belongs to the class of insecticides. It is administered orally and has a high bioavailability in rats and dogs. Afoxolaner has been shown to have a pharmacokinetic profile similar to that of the reference drug, deltamethrin, with an effective dose range from 0.1-0.5 mg/kg in rats and dogs. The terminal half-life of afoxolaner is 7 days after oral administration. Afoxolaner is also effective against fleas, ticks, lice, mites, and mosquitoes in animal models and has been shown to be safe for use in cats and dogs at doses up to 1mg/kg (1mg/kg). There are no reports of allergic reactions or cutaneous lesions related to afoxolaner treatment.Fórmula:C26H17ClF9N3O3Pureza:Min. 95%Forma y color:PowderPeso molecular:625.87 g/mol
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