CAS 109581-93-3

Hidrato de tacrolimus

Descripción:

Hidrato de tacrolimus, con el número CAS 109581-93-3, es un agente inmunosupresor utilizado principalmente en el trasplante de órganos y enfermedades autoinmunes. Se deriva de la bacteria Streptomyces tsukubaensis y funciona inhibiendo la activación de los linfocitos T, reduciendo así la respuesta inmune. La sustancia aparece como un polvo blanco a blanco amarillento y es soluble en disolventes orgánicos como el metanol y el dimetilsulfóxido, pero tiene una solubilidad limitada en agua. Hidrato de tacrolimus a menudo se formula como un ungüento tópico o medicamento oral, dependiendo de su aplicación. Sus efectos farmacológicos se atribuyen a su capacidad para unirse a FKBP-12, una proteína que posteriormente inhibe la calcineurina, una enzima crítica en la activación de células T. Aunque es efectivo, el tacrolimus puede tener efectos secundarios, incluyendo nefrotoxicidad y mayor susceptibilidad a infecciones, lo que requiere un monitoreo cuidadoso durante el tratamiento. En general, Hidrato de tacrolimus es un agente terapéutico vital en el manejo de condiciones que requieren supresión inmune.

Fórmula: C₄₄H₆₉NO₁₂·H₂O

InChI: InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1

Clave InChI: InChIKey=NWJQLQGQZSIBAF-MLAUYUEBSA-N

SMILES: O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@H](O)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H].O

Sinónimos:

• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-prop-2-en-1-yl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone hydrate
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, hydrate (1:1), (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
• 18-Tetramethyl-8-(2-Propenyl)-,Monohydrate,(3S-(3R*(E(1S*,3S*,4S*)),4S*,5R*
• 3-(2-(4-Hydroxy-3-Methoxycyclohexyl)-1-Methylethenyl)-14,16-Dimethoxy-9,10,12,Monohydrate
• FK-506 Monohydrate
• Tacforius
• Tacrolimus hydrate
• Tacrolimushydrate
• Tsukubaenolide hydrate

TACROLIMUS FOR SYSTEM SUITABILITY CRS

CAS: 109581-93-3

TACROLIMUS FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0001933

TACROLIMUS MONOHYDRATE CRS

CAS: 109581-93-3

TACROLIMUS MONOHYDRATE CRS

Fórmula: C₄₀H₃₃N₃O₄

Forma y color: Added Modified

Peso molecular: 619.7077

Ref: 41-Y0001926

Tacrolimus

CAS: 109581-93-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Forma y color: White Powder

Peso molecular: 803.48198

Ref: 45-1642802

Tacrolimus monohydrate

CAS: 109581-93-3

Fórmula: C₄₄H₇₁NO₁₃

Pureza: 80%

Forma y color: Solid

Peso molecular: 822.0334

Ref: IN-DA0035MN

FK-506 monohydrate

CAS: 109581-93-3

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Pureza: ≥ 98.0%

Forma y color: White to off-white solid or powder

Peso molecular: 822.03

Ref: 7W-GK6971

Tacrolimus monohydrate

CAS: 109581-93-3

Tacrolimus monohydrate

Pureza: ≥95%

Peso molecular: 822.05g/mol

Ref: 54-BUP14489

Tacrolimus Monohydrate

CAS: 109581-93-3

Tacrolimus Monohydrate

Pureza: 98%

Peso molecular: 822.03g/mol

Ref: 54-OR1025734

Tacrolimus Monohydrate

CAS: 104987-11-3, 109581-93-3

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Pureza: >80.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 822.05

Ref: 3B-M2258

Tacrolimus monohydrate

CAS: 109581-93-3

Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.

Fórmula: C₄₄H₇₁NO₁₃

Pureza: 97.07% - 98.05%

Forma y color: Solid

Peso molecular: 822.05

Ref: TM-T20879

Tacrolimus RS

CAS: 109581-93-3

Forma y color: White

Ref: 2K-1078400021

Tacrolimus Monohydrate

CAS: 109581-93-3

Fórmula: C₄₄H₆₉NO₁₂H₂O

Peso molecular: 804.0 : 18.0

Ref: ST-EA-CP-T39005

Tacrolimus Hydrate

CAS: 109581-93-3

Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Forma y color: Neat

Peso molecular: 822.03

Ref: TR-T004130

Tacrolimus monohydrate

CAS: 109581-93-3

Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerative

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 822.03 g/mol

Ref: 3D-FT33601

Tacrolimus monohydrate - Bio-X ™

CAS: 109581-93-3

Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.

Fórmula: C₄₄H₆₉NO₁₂·H₂O

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 822.03 g/mol

Ref: 3D-BT164433