CAS 11006-33-0

fleomicina de Streptomyces verticillus

Descripción:

La pleomicina es un antibiótico antitumoral derivado de la bacteria Streptomyces verticillus. Se caracteriza por su capacidad para inducir rupturas en las cadenas de ADN, lo que contribuye a su eficacia en el tratamiento del cáncer. La pleomicina es un glicopéptido, que consiste en una estructura compleja que incluye un esqueleto peptídico y un componente de azúcar, lo que mejora su solubilidad y actividad biológica. El compuesto exhibe un amplio espectro de actividad contra varios tipos de tumores, particularmente tumores de células germinales y linfomas. Su mecanismo de acción implica la unión al ADN y la generación de radicales libres, lo que conduce a daño oxidativo. La pleomicina se administra típicamente por inyección y es conocida por sus posibles efectos secundarios, incluyendo toxicidad pulmonar y reacciones cutáneas. Debido a sus propiedades únicas, a menudo se utiliza en combinación con otros agentes quimioterapéuticos para mejorar los resultados terapéuticos. El número CAS 11006-33-0 identifica de manera única la pleomicina en bases de datos químicas, facilitando la investigación y las aplicaciones clínicas.

Fórmula: C₅₅H₈₆N₂₀O₂₁S₂

InChI: InChI=1/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1

Sinónimos:

• 2'-{5-acetyl-15-(6-amino-2-{3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl}-5-methylpyrimidin-4-yl)-13-[{[(2R,3S,4S,5S,6S)-3-{[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)-3-methyltetrahydro-2H-pyran-2-yl]oxy}(1H-imidazol-5-yl)methyl]-9-hydroxy-8,10-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazapentadec-1-yl}-4',5'-dihydro-2,4'-bi-1,3-thiazole-4-carboxamide (non-preferred name)
• Phleomycin
• Phleomycin Streptomyces verticillus
• phleomycin from streptomyces*verticillus
• PHLEOMYCIN USP/EP/BP
• phleomycincomplex
• ZEOCIN(TM)
• CL990-cin
• PHLEOMYCIN FROM STREPOMYCES VERTICILLUS,
• nsc616586
• hleoMycin froM streptoMyces verticillus

Phleomycin, 20 mg/ml in 5mM HEPES buffer, sterile-filtered

CAS: 11006-33-0

Phleomycin, 11006-33-0, is a glycopeptide antibiotic produced in Streptomyces verticillus which acts as a specific inhibitor of DNA synthesis in bacteria. Learn more.

Ref: 02-J67027

Phleomycin

CAS: 11006-33-0

Fórmula: C₅₅H₈₅ClCuN₂₀O₂₁S₂

Pureza: 95%

Forma y color: Solid

Peso molecular: 1525.5138

Ref: IN-DA00HBO1

Phleomycin

CAS: 11006-33-0

Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage.

Fórmula: C₄₈H₆₉N₁₇O₂₀S₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 1268.29

Ref: TM-T21498

Phleomycin, 1 pack = 1 vial

CAS: 11006-33-0

Phleomycin, 1 pack = 1 vial

Ref: 54-BI3852A

Phleomycin

CAS: 11006-33-0

Phleomycin

Forma y color: Powder

Peso molecular: 1,425.51g/mol

Ref: 54-BI3852

Phleomycin

CAS: 11006-33-0

Fórmula: C₅₅H₈₅O₂₁N₂₀S₂Cu·HCl

Pureza: ≥ 90% (HPLC)

Forma y color: Blue, hygroscopic powder

Peso molecular: 1525

Ref: 7W-GA6020

Phleomycin HCl

CAS: 11006-33-0

Phleomycin HCl is an antibiotic compound derived from *Streptomyces verticillus*, which is known for its robust DNA-cleaving activity. As an antibiotic, it functions primarily by inducing breaks in DNA strands, thereby inhibiting DNA replication and transcription processes. This mechanism of action is particularly effective in targeting rapidly dividing cells, making Phleomycin a valuable tool in molecular biology.

Fórmula: C₅₅H₈₅O₂₁N₂₀S₂Cu•HCl

Forma y color: Blue Powder

Peso molecular: 1,525 g/mol

Ref: 3D-AP156948

Phleomycin (PLM) ex. Streptomyces verticillus for cell culture, Endotoxin (BET) 1.0EU/mg

CAS: 11006-33-0

Fórmula: C₅₁H₇₅N₁₇O₂₁S₂

Pureza: 80-120%

Forma y color: Blue, Powder

Peso molecular: 1326.37

Ref: SR-62374

Phleomycin

CAS: 11006-33-0

Phleomycin is an antibiotic, which is derived from the bacterium *Streptomyces verticillus*. Its mode of action involves binding to DNA and inducing breaks by generating free radicals in the presence of oxygen and ferrous ions, leading to cell death. Phleomycin is prominently used in molecular biology applications as a selective agent in the generation of stable transfectants. It is particularly effective in selecting for cells that have integrated vectors conferring resistance, such as the Sh ble gene used in yeast, plant, and mammalian cell systems. Due to its potent DNA-cleaving ability, Phleomycin is valuable in studies requiring stringent selection pressure. Researchers commonly utilize it in experiments focusing on genetic modification and cellular resistance development.

Fórmula: C₅₁H₇₅N₁₇O₂₁S₂

Pureza: Min. 95%

Peso molecular: 1,326.38 g/mol

Ref: 3D-AP106412