CAS 1135242-13-5

VU 0357017 Hydrochloride

CAS: 1135242-13-5

Fórmula: C₁₈H₂₈ClN₃O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 369.8862

Ref: IN-DA008TPP

4-[[2-[(2-Methylbenzoyl)Amino]Ethyl]Amino]-1-Piperidinecarboxylic Acid Ethyl Ester Monohydrochloride

CAS: 1135242-13-5

4-[[2-[(2-Methylbenzoyl)Amino]Ethyl]Amino]-1-Piperidinecarboxylic Acid Ethyl Ester Monohydrochloride

Pureza: 99%

Peso molecular: 369.9g/mol

Ref: 54-OR1025440

VU0357017 hydrochloride

CAS: 1135242-13-5

VU0357017 hydrochloride

Pureza: ≥98%

Peso molecular: 369.89g/mol

Ref: 54-BUP09980

VU0357017 monohydrochloride

CAS: 1135242-13-5

Fórmula: C₁₈H₂₇N₃O₃·HCl

Peso molecular: 369.89

Ref: 7W-GK1932

VU0357017 hydrochloride

CAS: 1135242-13-5

VU0357017 hydrochloride (ML071 hydrochloride) is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.

Fórmula: C₁₈H₂₈ClN₃O₃

Pureza: 99% - 99.97%

Forma y color: Solid

Peso molecular: 369.89

Ref: TM-T3619

Ethyl 4-((2-(2-methylbenzamido)ethyl)amino)piperidine-1-carboxylate hydrochloride

CAS: 1135242-13-5

Pureza: ≥98%(HPLC)

Peso molecular: 369.8900146

Ref: 10-F869523

VU 0357017 Hydrochloride

Producto controlado

CAS: 1135242-13-5

Applications VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.
References Bridges, et al.: Bioorg. Med. Chem. Lett., 20, 1972 (2010); Lebois, et al.: ACS Chem. Neurosci., 1, 104 (2010),

Fórmula: C₁₈H₂₇N₃O₃·ClH

Forma y color: Neat

Peso molecular: 369.886

Ref: TR-V787500

VU 0357017 hydrochloride

CAS: 1135242-13-5

Agonist of muscarinic receptors M1 and M4

Fórmula: C₁₈H₂₈ClN₃O₃

Pureza: Min. 95%

Peso molecular: 369.89 g/mol

Ref: 3D-FV28724