CAS 113852-37-2

Cidofovir

Descripción:

Cidofovir es un medicamento antiviral que se utiliza principalmente en el tratamiento de la retinitis por citomegalovirus (CMV) en pacientes con SIDA. Es un análogo de nucleótido de la citosina, que inhibe la ADN polimerasa viral, evitando así la replicación viral. Cidofovir se caracteriza por su alta potencia contra una variedad de virus de ADN, incluidos los herpesvirus. El compuesto se administra típicamente por vía intravenosa debido a su mala biodisponibilidad oral. Tiene una vida media relativamente larga, lo que permite una dosificación menos frecuente en comparación con otros agentes antivirales. Se sabe que Cidofovir tiene efectos nefrotóxicos, lo que requiere un monitoreo cuidadoso de la función renal durante el tratamiento. Además, a menudo se coadministra con probenecid para mitigar la nefrotoxicidad al reducir la secreción tubular renal. La sustancia se clasifica como un medicamento de prescripción y no se recomienda su uso en mujeres embarazadas debido a posibles efectos teratogénicos. En general, Cidofovir representa una opción terapéutica crítica para el manejo de infecciones virales severas en pacientes inmunocomprometidos.

Fórmula: C₈H₁₄N₃O₆P

InChI: InChI=1/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)

Clave InChI: InChIKey=VWFCHDSQECPREK-LURJTMIESA-N

SMILES: C([C@H](OCP(=O)(O)O)CO)N1C(=O)N=C(N)C=C1

Sinónimos:

• (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine
• (S)-Hpmpc
• ({[(2S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
• 1-(S)-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine
• 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine
• Cidofovir (anhydrous)
• Cidofovir monophosphate
• Cidovir
• Gs 0504
• Hpmpc
• P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, (S)-
• Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-
• Phosphonic acid, [[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-
• Unii-768M1V522C
• Vistide
• {[2-(4-amino-2-oxopyrimidin-1(2H)-yl)-1-(hydroxymethyl)ethoxy]methyl}phosphonic acid
• (S)-1-[3-HYDROXY-2-(PHOSPHONYL-METHOXY)PROPYL]-CYTOSINE
• (S)-1-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROYPL)CYTOSINE
• GS-504
• [[(S)-2-[(4-Amino-2-oxo-1,2-dihydropyrimidin)-1-yl]-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• [1-(4-amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid
• CIDOFOVIR
• CIDOFOVIR, S)-1-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROYPL)CYTOSINE
• (S)-[[2-(4-Amino-2-oxo-1(2H)pyrimidinyl)-l-(hydroxymethyl)ethoxy]methyl]phosphonic acid
• 1-[(2S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine

[1-(4-Amino-2-oxo-pyrimidin-1-yl)-3-hydroxy-propan-2-yl]oxymethylphosphonic acid

CAS: 113852-37-2

Fórmula: C₈H₁₄N₃O₆P

Pureza: 98%

Forma y color: Solid

Peso molecular: 279.1870

Ref: IN-DA00393G

Cidofovir, anhydrous

CAS: 113852-37-2

Fórmula: C₈H₁₄N₃O₆P

Peso molecular: 297.20

Ref: 7W-GP4917

Cidofovir

CAS: 113852-37-2

Cidofovir

Pureza: ≥98%

Peso molecular: 279.19g/mol

Ref: 54-BUP10119

Cidofovir

CAS: 113852-37-2

Cidofovir

Pureza: 98%

Peso molecular: 279.19g/mol

Ref: 54-OR1026524

Cidofovir hydrate

CAS: 113852-37-2

Fórmula: C₈H₁₄N₃O₆P·xH₂O

Pureza: 98.0 - 102.0 % (dried basis)

Forma y color: White or off-white crystalline powder

Peso molecular: 279.19 (anhydrous)

Ref: 7W-GP0753

Cidofovir

CAS: 113852-37-2

Fórmula: C₈H₁₄N₃O₆P

Forma y color: Neat

Peso molecular: 279.19

Ref: 04-C11666335

Cidofovir

Producto controlado

CAS: 113852-37-2

Fórmula: C₈H₁₄N₃O₆P

Forma y color: Neat

Peso molecular: 279.19

Ref: 86-MM3558.00

Cidofovir

CAS: 113852-37-2

Cidofovir ((S)-HPMPC) 通过特异性抑制病毒 DNA 合成来抑制病毒复制。

Fórmula: C₈H₁₄N₃O₆P

Pureza: 99.24% - 99.76%

Forma y color: Fluffy White Powder

Peso molecular: 279.19

Ref: TM-T6244

Cidofovir Hydrate

CAS: 113852-37-2

Applications An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human papillomavirus (HPV).
References Rahal, F.M. et al.: Ann. Internal Med., 125, 98 (1996); Johnson, J.A. et al.: Antimicrob. Agents Chemother., 43, 1190 (1999); Ho, H.T. et al.: Mol. Pharmacol., 41, 197 (1992);

Fórmula: C₈H₁₄N₃O₆P

Forma y color: White Powder

Peso molecular: 279.19

Ref: TR-C433500

Cidofovir anhydrous - Bio-X ™

CAS: 113852-37-2

Cidofovir is an anti-viral agent that is used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. This drug suppresses CMV replication by inhibiting viral DNA synthesis.

Fórmula: C₈H₁₄N₃O₆P

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 279.19 g/mol

Ref: 3D-BC164304

Cidofovir (anhydrous)

CAS: 113852-37-2

Anti-viral; DNA polymerase inhibitor

Fórmula: C₈H₁₄N₃O₆P

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 279.19 g/mol

Ref: 3D-FC46273