CAS 1146594-87-7

JNJ-40418677

CAS: 1146594-87-7

JNJ-40418677 is a small-molecule pharmaceutical compound that functions as a highly selective phosphodiesterase 10A (PDE10A) inhibitor. It is developed from synthetic chemical sources and is designed to modulate intracellular signaling pathways by targeting the PDE10A enzyme. The mode of action involves inhibition of PDE10A, which is predominantly expressed in the striatum—a brain region linked to motor control and cognitive functions. By inhibiting PDE10A, JNJ-40418677 increases the levels of cyclic nucleotides (cAMP and cGMP) within neurons, which can enhance dopaminergic and glutamatergic signaling pathways.

Fórmula: C₂₆H₂₂F₆O₂

Pureza: Min. 95%

Peso molecular: 480.44 g/mol

Ref: 3D-WVB59487

JNJ-40418677

CAS: 1146594-87-7

JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.

Fórmula: C₂₆H₂₂F₆O₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 480.44

Ref: TM-T24210