CAS 115966-23-9

Urodilatina

Descripción:

Urodilatina es un péptido que se deriva de la prohormona pro-péptido natriurético atrial (pro-ANP) y está principalmente involucrado en la regulación de la función renal y el equilibrio de fluidos. Se caracteriza por su papel como agente natriurético, promoviendo la excreción de sodio y agua, lo que ayuda a reducir el volumen sanguíneo y a bajar la presión arterial. Urodilatina se produce en los riñones y actúa sobre los túbulos renales, mejorando la diuresis y la natriuresis. Su estructura consiste en una secuencia de aminoácidos que confieren su actividad biológica, y se sabe que interactúa con receptores específicos en el cuerpo, lo que lleva a la vasodilatación y al aumento de la tasa de filtración glomerular. El potencial terapéutico de Urodilatina se está explorando en condiciones como la insuficiencia cardíaca y la hipertensión, donde la sobrecarga de fluidos es una preocupación. En general, sus propiedades únicas lo convierten en una molécula importante en la fisiología cardiovascular y renal.

Fórmula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

InChI: InChI=1/C145H234N52O44S3/c1-11-72(6)112-137(238)171-60-106(208)172-73(7)113(214)177-86(40-41-103(146)205)122(223)190-95(63-198)116(217)170-61-108(210)175-88(51-70(2)3)114(215)169-62-109(211)176-100(133(234)187-92(56-104(147)206)127(228)193-97(65-200)130(231)186-91(54-77-27-16-13-17-28-77)126(227)180-82(31-20-45-163-142(153)154)119(220)189-94(139(240)241)55-78-36-38-79(204)39-37-78)68-243-244-69-101(134(235)185-90(53-76-25-14-12-15-26-76)115(216)168-58-105(207)167-59-107(209)174-80(29-18-43-161-140(149)150)117(218)182-87(42-50-242-10)123(224)188-93(57-110(212)213)128(229)181-85(124(225)196-112)34-23-48-166-145(159)160)195-132(233)99(67-202)194-131(232)98(66-201)192-120(221)83(32-21-46-164-143(155)156)178-118(219)81(30-19-44-162-141(151)152)179-125(226)89(52-71(4)5)184-129(230)96(64-199)191-121(222)84(33-22-47-165-144(157)158)183-135(236)102-35-24-49-197(102)138(239)74(8)173-136(237)111(148)75(9)203/h12-17,25-28,36-39,70-75,80-102,111-112,198-204H,11,18-24,29-35,40-69,148H2,1-10H3,(H2,146,205)(H2,147,206)(H,167,207)(H,168,216)(H,169,215)(H,170,217)(H,171,238)(H,172,208)(H,173,237)(H,174,209)(H,175,210)(H,176,211)(H,177,214)(H,178,219)(H,179,226)(H,180,227)(H,181,229)(H,182,218)(H,183,236)(H,184,230)(H,185,235)(H,186,231)(H,187,234)(H,188,224)(H,189,220)(H,190,223)(H,191,222)(H,192,221)(H,193,228)(H,194,232)(H,195,233)(H,196,225)(H,212,213)(H,240,241)(H4,149,150,161)(H4,151,152,162)(H4,153,154,163)(H4,155,156,164)(H4,157,158,165)(H4,159,160,166)/t72-,73-,74-,75+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-/m0/s1

Sinónimos:

• Anp 95-126
• H-Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bond)
• Proatrial natriuretic peptide (95-126)
• Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human)
• Urodilatin
• Urodilatin (CDD/ANP-95-126)
• THR-ALA-PRO-ARG-ATRIAL NATRIURETIC PEPTIDE
• URODILATIN CCC/ANP, 95-126
• Thr-Ala-Pro-Arg-Atrial Natriuretic Peptide, Urodilatin, human
• H-THR-ALA-PRO-ARG-SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR-OH (DISULFIDE BRIDGE: 11-27)
• Urodilatin CCC
• THR-ALA-PRO-ARG-SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR(DISULFIDE BRIDGE CYS11- CYS 27)
• TAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY (DISULFIDE BRIDGE: 11-27)
• THR-ALA-PRO-ARG-ATRIAL NATRIURETIC PEPTIDE HUMAN
• THR-ALA-PRO-ARG-ANP, HUMAN
• CCC/ANP-95-126
• Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (huMan, bovine, porcine)
• URODILATIN HUMAN
• URODILATIN (95-126)
• Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt
• THR-ALA-PRO-ARG-SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR
• Urodilatin, Ularitide
• CDD/ANP-95-126

Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine)

CAS: 115966-23-9

Urodilatin, a 32 amino acid peptide, has originally been isolated from human urine. It belongs to the family of natriuretic-vasorelaxant peptides earlier found in heart atria. Cedidi et al. showed that urodilatin infusion may represent a concept for the treatment of therapy-resistant acute renal failure after liver transplantation. The use of ularitide is protected by patents. It is sold by Bachem for research purposes only, by expressed permission of Pharis Biotec GmbH, Hannover, Germany (www.pharis-biotec.com).

Fórmula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

Pureza: ≥ 95%

Forma y color: White Powder

Peso molecular: 3505.98

Ref: 01-4030382

Urodilatin

CAS: 115966-23-9

Fórmula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

Pureza: 95%

Peso molecular: 3505.9265

Ref: IN-DA000H8N

Urodilatin

CAS: 115966-23-9

Urodilatin, an analogue of ANF-(99-126), serves as a diuretic-natriuretic regulatory peptide with applications in the study of acute renal failure, congestive

Forma y color: Solid

Ref: TM-T80891

Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt

CAS: 115966-23-9

Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt is a peptide hormone that regulates blood pressure by causing the kidneys to excrete sodium and water. It is used as a model system for studying the physiological effects of urodilatin and has been shown to inhibit the cyclase enzyme. Thr-Ala-Pro-Arg-Atrial Natriuretic Factor (1-28) (human, bovine, porcine) trifluoroacetate salt may also have an antihypertensive effect through its ability to reduce levels of natriuretic peptides in plasma. This drug is also being investigated as a possible treatment for congestive heart failure. The small molecular weight makes it suitable for use as a natriuretic or antihypertensive drug with minimal side effects.

Fórmula: C₁₄₅H₂₃₄N₅₂O₄₄S₃

Pureza: Min. 95%

Peso molecular: 3,505.93 g/mol

Ref: 3D-FT108857