CAS 117399-94-7
:endotelina 1
Descripción:
La endotelina-1 (ET-1) es un péptido potente vasoconstrictor que desempeña un papel crucial en varios procesos fisiológicos y patológicos, particularmente en el sistema cardiovascular. Es un péptido de 21 aminoácidos producido principalmente por células endoteliales y está involucrado en la regulación de la presión arterial, el tono vascular y el equilibrio de fluidos. Se conoce que la ET-1 tiene la capacidad de inducir la contracción del músculo liso y promover la proliferación celular, lo que la hace significativa en condiciones como la hipertensión y la insuficiencia cardíaca. El péptido ejerce sus efectos a través de receptores específicos, principalmente el receptor de endotelina tipo A (ETA) y tipo B (ETB), que están distribuidos por todo el cuerpo. Además de sus efectos cardiovasculares, la endotelina-1 está implicada en varios otros procesos biológicos, incluyendo la inflamación, el crecimiento celular y la neurobiología. Debido a sus potentes efectos, la ET-1 es un objetivo para intervenciones terapéuticas en enfermedades caracterizadas por una vasoconstricción excesiva y remodelación tisular. Su número CAS, 117399-94-7, se utiliza para la identificación en bases de datos químicas y contextos regulatorios.
Fórmula:C109H159N25O32S5
InChI:InChI=1/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)
SMILES:CCC(C)C(C(=NC(Cc1c[nH]c2ccccc12)C(=O)O)O)N=C(C(C(C)CC)N=C(C(CC(=O)O)N=C(C(CC(C)C)N=C(C(Cc1cnc[nH]1)N=C(C1CSSCC(C(=NC(CO)C(=NC2CSSCC(C(=NC(C(C)C)C(=NC(Cc3ccc(cc3)O)C(=NC(Cc3ccccc3)C(=N1)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CCCCN)N=C(C(CC(=O)O)N=C(C(CCSC)N=C(C(CC(C)C)N=C(C(CO)N=C(C(CO)N=C2O)O)O)O)O)O)O)O)O)O)N)O)O)O)O)O
Sinónimos:- Endothelin 1 human, porcine
- H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bonds between Cys1 and Cys15/Cys3 and Cys11)
- Endothelin 1, Human and Porcine
- Endothelin-1,Human
- Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt
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Encontrado 8 productos.
Endothelin-1 (human, bovine, dog, mouse, porcine, rat)
CAS:Endothelin-1 (ET-1) is a potent vasoconstrictive 21-amino acid peptide produced by endothelia cells. It acts on endothelia cells and on the underlying smooth muscle cells as a modulator of vascular tone. ET-1 shows selectivity for the ET-A receptor.Fórmula:C109H159N25O32S5Pureza:95.0%Forma y color:WhitePeso molecular:2491.94Endothelin-1 (human, bovine, dog, mouse, porcine, rat)
CAS:Endothelin-1, a 21-amino acid peptide from vascular endothelial cells of different mammalian species, is one of the most potent vasoconstrictors. ET-1 exerts a wide variety of effects on both vascular and non-vascular (e.g. heart, lung, brain) tissues. Toxic peptides from a snake venom, the sarafotoxins, show structural and functional homology to ET-1. The role of ET-1 in clinical hypertension has been reviewed by Dhaun et al. and by Sreenivas and Oparil. ET-1 plays a central role in lung fibrosis.Fórmula:C109H159N25O32S5Pureza:91.90%Forma y color:WhitePeso molecular:2491.94Endothelin-1 Acetate
CAS:Fórmula:C109H159N25O32S5Pureza:95%~99%Forma y color:White to Off-white PowderPeso molecular:2491.9Endothelin 1 (swine, human)
CAS:Endothelin 1, a strong vasoconstrictor, targets ETA/ETB receptors, with a synthetic human/swine peptide sequence.Fórmula:C109H159N25O32S5Forma y color:White PowderPeso molecular:2491.9Endothelin-1 (Human)
CAS:<p>Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure. Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle. This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11, sourced from Porcine, Canine, Rat, Mouse and Bovine and is available as a 0.1mg vial.</p>Fórmula:C109H159N25O32S5Pureza:Min. 95%Peso molecular:2,491.9 g/molEndothelin-1 (Human)
CAS:<p>Endothelin-1 is a peptide that acts as a vasoconstrictor and plays an important role in the regulation of blood pressure. Endothelin-1 is also an endogenous ligand for two G protein-coupled receptors, ETA and ETB. Interesting Endothelin-1 is the most abundant isoform and is expressed in endothelial cells of every blood vessel. It exerts its vasoconstrictor effects through binding to ETA receptors located on the smooth muscle.<br>This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11, sourced from Porcine, Canine, Rat, Mouse and Bovine and is available as a 0.5mg vial.</p>Fórmula:C109H159N25O32S5Pureza:Min. 95%Peso molecular:2,491.9 g/molEndothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate
CAS:<p>Endothelin-1 (ET-1) is a peptide that is produced by the endothelium. ET-1 is involved in numerous biological processes, including vasoconstriction, inflammation, and cell proliferation. Endothelin-1 (human ET-1) acetate salt H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-(Glu)-Cys-(Val)-Tyr-(Phe)-Cys-(His)-Leu -Asp(-Ile)-Ile(-Trp)) acetate salt is a recombinant protein that has been shown to significantly upregulate the production of endothelin in primary pulmonary hypertension. It also plays an important role in bowel disease, where it may be involved in the development of chronic inflammatory bowel disease.</p>Fórmula:C109H159N25O32S5•(C2H4O2)xPureza:Min. 95%Peso molecular:2,491.91 g/mol
