CAS 118414-82-7

MK-886

Descripción:

MK-886, con el número CAS 118414-82-7, es un compuesto sintético que funciona principalmente como un inhibidor selectivo de la enzima 5-lipoxigenasa (5-LO). Esta enzima juega un papel crucial en la biosíntesis de leucotrienos, que son mediadores inflamatorios involucrados en diversas condiciones patológicas, incluyendo el asma y otras enfermedades inflamatorias. MK-886 se caracteriza por su capacidad para modular las respuestas inflamatorias, lo que lo convierte en un tema de interés en la investigación farmacológica. El compuesto se estudia típicamente por sus posibles aplicaciones terapéuticas en el tratamiento de condiciones asociadas con la producción excesiva de leucotrienos. En términos de su estructura química, MK-886 presenta una disposición distintiva de grupos funcionales que contribuyen a su actividad biológica. Es importante señalar que, aunque MK-886 ha mostrado promesas en estudios preclínicos, se necesita más investigación para comprender completamente su eficacia, perfil de seguridad y posibles aplicaciones clínicas. Al igual que muchos compuestos en investigación, su uso está principalmente confinado a entornos de investigación hasta que se disponga de datos clínicos más definitivos.

Fórmula: C₂₇H₃₃ClNO₂S·Na

InChI: InChI=1/C27H34ClNO2S/c1-6-7-14-32-25-22-15-20(18(2)3)10-13-23(22)29(17-19-8-11-21(28)12-9-19)24(25)16-27(4,5)26(30)31/h8-13,15,18H,6-7,14,16-17H2,1-5H3,(H,30,31)

Clave InChI: InChIKey=QAOAOVKBIIKRNL-UHFFFAOYSA-N

SMILES: C(N1C=2C(C(SC(C)(C)C)=C1CC(C(O)=O)(C)C)=CC(C(C)C)=CC2)C3=CC=C(Cl)C=C3

Sinónimos:

• 1-((4-Chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
• 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid
• 1H-Indole-2-propanoic acid, 1-((4-chlorophenyl)methyl)-3-((1,1-dimethylethyl)thio)-alpha,alpha-dimethyl-5-(1-methylethyl)-
• 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-
• 3-(1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid
• 3-[3-(butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• L 663536
• MK 886
• MK 886
• CGS-81585
• 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-diMethylpropanoic acid
• 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• 3-[1-(4-Chlorobenzyl)-3-(tert-butylthio)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid
• 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid
• 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt
• MK866
• 1-[(4-Chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-Indole-2-propanoicacid
• MK-886 (L-663,536)
• MK-886 (Free Base)

1H-Indole-2-propanoic acid,1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-a,a-dimethyl-5-(1-methylethyl)-

CAS: 118414-82-7

Fórmula: C₂₇H₃₄ClNO₂S

Pureza: 98%

Forma y color: Solid

Peso molecular: 472.0824

Ref: IN-DA008RN6

3-(3-(Tert-Butylthio)-1-(4-Chlorobenzyl)-5-Isopropyl-1H-Indol-2-Yl)-2,2-Dimethylpropanoic Acid

CAS: 118414-82-7

3-(3-(Tert-Butylthio)-1-(4-Chlorobenzyl)-5-Isopropyl-1H-Indol-2-Yl)-2,2-Dimethylpropanoic Acid

Pureza: 98%

Peso molecular: 472.08g/mol

Ref: 54-OR1026587

MK-886

CAS: 118414-82-7

MK-886

Pureza: ≥98%

Peso molecular: 472.08g/mol

Ref: 54-BUP07765

MK-886

CAS: 118414-82-7

MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP).

Fórmula: C₂₇H₃₄ClNO₂S

Pureza: 99.23% - 99.84%

Forma y color: Solid

Peso molecular: 472.08

Ref: TM-T6893

MK-886

CAS: 118414-82-7

MK-886 is a synthetic compound, formally classified as a leukotriene biosynthesis inhibitor, which is derived through chemical synthesis processes. This compound acts by specifically targeting the 5-lipoxygenase-activating protein (FLAP), a crucial component in the leukotriene synthesis pathway. By inhibiting FLAP, MK-886 effectively suppresses the production of leukotrienes, which are lipid compounds that play a pivotal role in the inflammatory response.

Fórmula: C₂₇H₃₄ClNO₂S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 472.08 g/mol

Ref: 3D-TEA41482

MK 886 - Bio-X ™

CAS: 118414-82-7

MK 886 is a leukotriene antagonist that has been studied for use in treating atherosclerosis. This drug inhibits the 5-lipoxygenase activating protein thus inhibiting 5-lipoxygenase.

Fórmula: C₂₇H₃₄ClNO₂S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 472.08 g/mol

Ref: 3D-BM166037

MK-886

Producto controlado

CAS: 118414-82-7

Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1.
References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);

Fórmula: C₂₇H₃₄ClNO₂S

Forma y color: Neat

Peso molecular: 472.08

Ref: TR-M425053