CAS 1187594-09-7

Baricitinib

Descripción:

Baricitinib es un fármaco de molécula pequeña utilizado principalmente para el tratamiento de la artritis reumatoide moderada a severa. Funciona como un inhibidor selectivo de las enzimas Janus quinasa (JAK), específicamente JAK1 y JAK2, que desempeñan un papel crucial en las vías de señalización de varias citoquinas involucradas en procesos inflamatorios. La fórmula química de Baricitinib es C16H17N3O2, y tiene un peso molecular de aproximadamente 285.33 g/mol. La sustancia aparece como un polvo cristalino blanco a blanco sucio y es soluble en dimetilsulfóxido (DMSO) y ligeramente soluble en agua. Baricitinib se administra por vía oral y ha demostrado reducir los signos y síntomas de la artritis reumatoide al modular la respuesta inmune. Su farmacocinética indica una vida media relativamente larga, lo que permite una dosificación una vez al día. Al igual que con cualquier medicamento, los efectos secundarios potenciales incluyen un mayor riesgo de infecciones, elevaciones de enzimas hepáticas y cambios en los recuentos de células sanguíneas, lo que requiere monitoreo durante el tratamiento.

Fórmula: C₁₆H₁₇N₇O₂S

InChI: InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)

Clave InChI: InChIKey=XUZMWHLSFXCVMG-UHFFFAOYSA-N

SMILES: C(C#N)C1(CN(S(CC)(=O)=O)C1)N2C=C(C=N2)C3=C4C(=NC=N3)NC=C4

Sinónimos:

• 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
• 2-(3-(4-(3H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
• 2-(3-(4-(7H-Pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
• 3-Azetidineacetonitrile, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-
• Incb 028050
• Incb 28050
• Incb028050
• Ly 3009104
• Ly3009104
• Olumiant
• Baricitinib
• 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile Baricitinib (LY3009104, INCB028050)
• Baricitinib(INCB 028050
• aricitinib (LY3009104, INCB028050)
• Baricitinib (LY3009104)
• Baricitinib/INCB 028050/LY3009104
• Baricitinib (LY3009104, INCB028050)

1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile

CAS: 1187594-09-7

Fórmula: C₁₆H₁₇N₇O₂S

Pureza: 99%

Forma y color: Solid

Peso molecular: 371.4169

Ref: IN-DA003A5U

Baricitinib

CAS: 1187594-09-7

Baricitinib

Pureza: ≥98%

Peso molecular: 371.42g/mol

Ref: 54-BUP15488

Baricitinib

CAS: 1187594-09-7

Fórmula: C₁₆H₁₇N₇O₂S

Forma y color: White To Off-White Solid

Peso molecular: 371.42

Ref: 4Z-B-154001

Baricitinib

CAS: 1187594-09-7

Forma y color: Neat

Ref: 86-MM3905.00

Baricitinib

CAS: 1187594-09-7

Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.

Fórmula: C₁₆H₁₇N₇O₂S

Pureza: 99% - >99.99%

Forma y color: Solid

Peso molecular: 371.42

Ref: TM-T2485

Baricitinib

CAS: 1187594-09-7

Fórmula: C₁₆H₁₇N₇O₂S

Pureza: ≥ 98.0%

Forma y color: White to off-white solid

Peso molecular: 371.4

Ref: 7W-GW9910

Baricitinib

Producto controlado

CAS: 1187594-09-7

Applications Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.
References Greenwald, L.J., et al.: Int. J. Clin. Rheumatol., 6, 401 (2011); Fridman, J.S., et al.: J. Immunol., 184, 5298 (2010);

Fórmula: C₁₆H₁₇N₇O₂S

Forma y color: White Solid

Peso molecular: 371.42

Ref: TR-B118690

Baricitinib

CAS: 1187594-09-7

Baricitinib is a Janus kinase inhibitor (JAK) currently used as monotherapy in the treatment of rheumatoid arthritis. Barictinib is also recommened for the treatment of atopic dermatitis and systemic lupus erythematosus. In mice interestingly, the administration of baricitinib reduced the inflammatory effects induced by a high-sugar diet on the metabolism.

Fórmula: C₁₆H₁₇N₇O₂S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 371.42 g/mol

Ref: 3D-FE30357

Baricitinib - Bio-X ™

CAS: 1187594-09-7

Baricitinib is a Janus kinase inhibitor (JAK) currently used as monotherapy in the treatment of rheumatoid arthritis. Barictinib is also recommened for the treatment of atopic dermatitis and systemic lupus erythematosus. In mice interestingly, the administration of baricitinib reduced the inflammatory effects induced by a high-sugar diet on the metabolism.
Baricitinib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₆H₁₇N₇O₂S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 371.42 g/mol

Ref: 3D-BB184033

BARICITINIB

CAS: 1187594-09-7

Fórmula: C₁₆H₁₇N₇O₂S

Pureza: 95%

Forma y color: Solid

Peso molecular: 371.42

Ref: 10-F468368

Baricitinib Azetidine-d4

Producto controlado

CAS: 1187594-09-7

Fórmula: C₁₆H₁₃D₄N₇O₂S

Forma y color: Neat

Peso molecular: 375.44

Ref: TR-B118694