CAS 120011-70-3

Clorhidrato de donepezilo

Descripción:

Clorhidrato de donepezilo es un inhibidor reversible de la enzima acetilcolinesterasa, utilizado principalmente en el tratamiento de la enfermedad de Alzheimer y otros trastornos cognitivos. Mejora la función colinérgica al aumentar los niveles de acetilcolina en el cerebro, lo cual es crucial para la memoria y el aprendizaje. El compuesto se administra típicamente en forma de sal hidrocloruro, lo que mejora su solubilidad y biodisponibilidad. Clorhidrato de donepezilo se caracteriza por su fórmula molecular, que incluye átomos de carbono, hidrógeno, nitrógeno y oxígeno, y tiene un peso molecular específico. La sustancia se presenta generalmente como un polvo cristalino blanco a blanco sucio, y es soluble en agua y alcohol. Su farmacocinética indica que tiene una vida media relativamente larga, lo que permite una dosificación una vez al día. Los efectos secundarios comunes pueden incluir trastornos gastrointestinales, insomnio y calambres musculares. Al igual que con cualquier medicamento, es esencial usar Clorhidrato de donepezilo bajo supervisión médica para monitorear la eficacia y las posibles reacciones adversas.

Fórmula: C₂₄H₃₀ClNO₃

InChI: InChI=1/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H

Clave InChI: InChIKey=XWAIAVWHZJNZQQ-UHFFFAOYSA-N

SMILES: O=C1C=2C(=CC(OC)=C(OC)C2)CC1CC3CCN(CC4=CC=CC=C4)CC3.Cl

Sinónimos:

• 1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride
• 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride
• 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1)
• 2,3-Dihydro-5,6-Dimethoxy-2-[[1-(Phenylmethyl)-4-Piperidinyl]Methyl]-1H-Inden-1-One Hydrochloride
• 2,3-dihydro-5,6-dimethoxy-2-{[1-(phemylmethyl)-4-piperidinyl]methyl}-1H-indan-1-one HCL
• 2-(1-Benzylpiperidin-4-ylmethyl)-5,6-dimethoxyindan-1-one hydrochloride
• 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride (1:1)
• Akos 226-31
• Aricept
• Aricept D
• Aricept ODT
• Aricept, E-2020 Donepezil HCl
• Donep
• Donepezil HCl
• DonepezilHCL
• DonepezilHcl120011-70-3
• Donezepil hydrochloride
• Dopezil
• Dorent
• E 2020 (pharmaceutical)
• E-2020
• BNAG
• 1h-inden-1-one,2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)me
• e2020(pharmaceutical)
• Donepezi
• DONEPEZIL HYDROCHLORIDE
• Aricept, E-2020
• 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]-1H-inden-1-one
• Donepezil and its intermediates

Donepezil Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 120011-70-3

Forma y color: Single Solution

Ref: 61-AMP0677.00-01

Donepezil Hydrochloride

CAS: 120011-70-3

Forma y color: Neat

Ref: 61-FOR0677.00

DONEPEZIL HYDROCHLORIDE CRS

CAS: 120011-70-3

DONEPEZIL HYDROCHLORIDE CRS

Ref: 41-Y0002160

1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1)

CAS: 120011-70-3

Fórmula: C₂₄H₃₀ClNO₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 415.9529

Ref: IN-DA000Q2S

2-((1-Benzylpiperidin-4-Yl)Methyl)-5,6-Dimethoxy-2,3-Dihydro-1H-Inden-1-One Hydrochloride

CAS: 120011-70-3

2-((1-Benzylpiperidin-4-Yl)Methyl)-5,6-Dimethoxy-2,3-Dihydro-1H-Inden-1-One Hydrochloride

Pureza: 98%

Peso molecular: 415.95g/mol

Ref: 54-OR1009606

Donepezil-d5 HCl

CAS: 120011-70-3

Fórmula: C₂₄H₂₄D₅NO₃·HCl

Forma y color: White To Off-White Solid

Peso molecular: 384.53 36.46

Ref: 4Z-D-1329

Donepezil Hydrochloride

CAS: 120011-70-3

Donepezil Hydrochloride

Pureza: ≥98%

Peso molecular: 415.96g/mol

Ref: 54-BUP15759

Donepezil Hydrochloride

CAS: 120011-70-3, 120014-06-4

Fórmula: C₂₄H₂₉NO₃·HCl

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 415.96

Ref: 3B-D4099

Donepezil Hydrochloride

CAS: 120011-70-3

Forma y color: Neat

Ref: 86-MM0677.00

Donepezil Hydrochloride

CAS: 120011-70-3

Donepezil HCl(Aricept) is a selective and effective AChE inhibitor for bAChE and hAChE (IC50: 8.12/11.6 nM).

Fórmula: C₂₄H₂₉NO₃·HCl

Pureza: 99.55% - 99.8%

Forma y color: White To Off-White Crystalline Solid

Peso molecular: 415.96

Ref: TM-T6478

Donepezil hydrochloride

CAS: 120011-70-3

Fórmula: C₂₄H₂₉NO₃·HCl·H₂O

Pureza: ≥ 98.0%

Forma y color: White to off-white crystalline powder

Peso molecular: 415.95 (anhydrous)

Ref: 7W-GP8656

Donepezil Hydrochloride RS

CAS: 120011-70-3

Forma y color: White Solid Crystalline Powder

Ref: 2K-1090500021

Donepezil hydrochloride

CAS: 120011-70-3

Pureza: 99.00%

Forma y color: Solid

Peso molecular: 415.96

Ref: 10-F036568

Donepezil Hydrochloride

CAS: 120011-70-3

Fórmula: C₂₄H₂₉NO₃HCl

Peso molecular: 379.5 : 36.46

Ref: ST-EA-CP-D2018

Donepezil Hydrochloride

Producto controlado

CAS: 120011-70-3

Stability Hygroscopic
Applications A nootropic. An inhibitor of acetylcholinesterase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ohnishi, A., et al.: J. Clin. Pharmacol., 33, 1086 (1993); Galli, A., et al.: Eur. J. Pharmacol., 270, 189 (1994);

Fórmula: C₂₄H₂₉NO₃·ClH

Forma y color: White To Off-White

Peso molecular: 415.95

Ref: TR-D531750

Donepezil HCl

Producto controlado

CAS: 120011-70-3

Reversible inhibitor of cholinesterases

Fórmula: C₂₄H₂₉NO₃·HCl

Pureza: Min. 98 Area-%

Forma y color: White Powder

Peso molecular: 415.95 g/mol

Ref: 3D-FD29053

Donepezil HCl - Bio-X ™

Producto controlado

CAS: 120011-70-3

Donepezil HCl is a reversible inhibitor of acetylcholinesterase (AChE), a type of cholinesterase enzyme. Donepezil HCl temporarily binds to and blocks the active site of the enzyme, inhibiting the enzyme's ability to break down acetylcholine, a neurotransmitter involved in learning and memory. This increase in acetylcholine concentrations at cholinergic synapses helps improve cognitive function in patients with Alzheimer's disease. Donepezil HCl may also have a role in calcium signalling through interaction with sigma receptors in the endoplasmic reticulum (ER).

Fórmula: C₂₄H₃₀ClNO₃

Pureza: Min. 99 Area-%

Forma y color: Off-White Powder

Peso molecular: 415.95 g/mol

Ref: 3D-BD164380

Donepezil hydrochloride

Producto controlado

CAS: 120011-70-3

Fórmula: C₂₄H₂₉NO₃·ClH

Forma y color: Neat

Peso molecular: 415.95

Ref: 04-C13081750