CAS 121695-87-2

Sarafotoxina S6C

Descripción:

Sarafotoxina S6C es una toxina peptídica derivada del veneno de ciertas especies de serpientes, particularmente aquellas de la familia Viperidae. Es conocida por su potente actividad biológica, principalmente como una neurotoxina que afecta el sistema cardiovascular. Sarafotoxina S6C exhibe alta afinidad por receptores específicos, lo que lleva a la vasoconstricción y al aumento de la presión arterial. Su estructura típicamente incluye una serie de aminoácidos dispuestos en una secuencia específica, contribuyendo a su estabilidad y actividad. La toxina se estudia a menudo por sus posibles implicaciones en farmacología y toxicología, ya que puede proporcionar información sobre interacciones de receptores y vías de señalización. Además, debido a sus efectos biológicos, Sarafotoxina S6C es de interés en la investigación relacionada con la hipertensión y otros trastornos cardiovasculares. Las precauciones de seguridad son esenciales al manejar esta sustancia, ya que puede representar riesgos significativos para la salud. En general, Sarafotoxina S6C sirve como un modelo valioso para comprender los mecanismos de las toxinas peptídicas y sus posibles aplicaciones terapéuticas.

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

InChI: InChI=1/C103H147N27O37S5/c1-10-46(6)80(100(163)123-67(103(166)167)30-50-37-109-54-19-15-14-18-52(50)54)128-99(162)79(45(4)5)127-95(158)66(36-78(144)145)120-85(148)55(20-23-71(105)133)112-90(153)61(31-51-38-108-43-110-51)117-97(160)69-40-170-169-39-53(104)83(146)129-81(47(7)131)102(165)126-70-42-172-171-41-68(96(159)115-59(28-44(2)3)88(151)118-62(32-72(106)134)91(154)116-60(89(152)125-69)29-49-16-12-11-13-17-49)124-86(149)57(22-25-75(138)139)111-84(147)56(21-24-74(136)137)113-94(157)65(35-77(142)143)122-101(164)82(48(8)132)130-87(150)58(26-27-168-9)114-93(156)64(34-76(140)141)121-92(155)63(33-73(107)135)119-98(70)161/h11-19,37-38,43-48,53,55-70,79-82,109,131-132H,10,20-36,39-42,104H2,1-9H3,(H2,105,133)(H2,106,134)(H2,107,135)(H,108,110)(H,111,147)(H,112,153)(H,113,157)(H,114,156)(H,115,159)(H,116,154)(H,117,160)(H,118,151)(H,119,161)(H,120,148)(H,121,155)(H,122,164)(H,123,163)(H,124,149)(H,125,152)(H,126,165)(H,127,158)(H,128,162)(H,129,146)(H,130,150)(H,136,137)(H,138,139)(H,140,141)(H,142,143)(H,144,145)(H,166,167)

SMILES: CCC(C)C(C(=NC(Cc1c[nH]c2ccccc12)C(=O)O)O)N=C(C(C(C)C)N=C(C(CC(=O)O)N=C(C(CCC(=N)O)N=C(C(Cc1cnc[nH]1)N=C(C1CSSCC(C(=NC(C(C)O)C(=NC2CSSCC(C(=NC(CC(C)C)C(=NC(CC(=N)O)C(=NC(Cc3ccccc3)C(=N1)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CCC(=O)O)N=C(C(CC(=O)O)N=C(C(C(C)O)N=C(C(CCSC)N=C(C(CC(=O)O)N=C(C(CC(=N)O)N=C2O)O)O)O)O)O)O)O)O)O)N)O)O)O)O)O

Sinónimos:

• Srtx-C
• Sarafotoxin S6C (Atractaspis Engaddensis)
• Sarafotoxin S6C, Atractaspsis Engaddensis
• Sarafotoxin 6C
• Sarafotoxin C
• Sarafotoxin C (Atractaspis Engaddensis)
• Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp

Sarafotoxin C

CAS: 121695-87-2

Highly selective ET-B receptor agonist.

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Pureza: > 95%

Forma y color: White Powder

Peso molecular: 2515.79

Ref: 01-4031255

Sarafotoxin S6c

CAS: 121695-87-2

Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 2516

Ref: TM-TP2120

Sarafotoxin S6c

CAS: 121695-87-2

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Pureza: ≥ 95.0%

Forma y color: White lyophilised powder

Peso molecular: 2515.75

Ref: 7W-GK0055

Sarafotoxin S6c

CAS: 121695-87-2

Sarafotoxin S6c, sourced from the venom of the Atractaspis engaddensis snake family, is one of four (S6a-d) isopeptides of the Sarafotoxins. This product is a synthetically produced toxin, containing disulfide bonds between Cys1-Cys15 and Cys3-Cys11.
Due to their structural and functional homology to the endothelin peptides, Sarafotoxins can enhance vasoconstriction through stimulating the class A G-protein-coupled, endothelin ETA and ETB receptors. This in turn leads to left ventricular dysfunction and bronchoconstriction. Compared to the sarafotoxin isopeptide S6b, S6c is less toxic with a 100 to 10,000-fold reduced affinity for the ETA receptor, therefore acts as a selective agonist to the ETB receptor. One study demonstrated that when sarafotoxin 6c was used to activate ETB receptors in rats there was an increase in arterial pressure, known as S6c-induced hypertension.
As the upregulation of Endothelin-1 (ET-1) is related to circulatory-system diseases, the interaction between ET-1 and its receptors is highly important for development of endothelin receptor antagonist treatments. Sarafotoxin S6c can be used as a pharmacological reagent to study these interactions.

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Pureza: Min. 95%

Peso molecular: 2,515.8 g/mol

Ref: 3D-PSF-4246-S

Sarafotoxin C trifluoroacetate salt

CAS: 121695-87-2

Sarafotoxin C is a peptide from the venom of the spider Phoneutria nigriventer that has been shown to have potent inhibitory properties on endothelin-1. Sarafotoxin C is able to block intracellular Ca2+ levels and signal pathways, leading to decreased levels of endothelin-1 as well as other inflammatory mediators. Sarafotoxin C has also been shown to have an anti-inflammatory effect in bowel disease, which may be due to its ability to inhibit the production of cytokines and prostaglandins. The biological properties of sarafotoxin C are related to its inhibition of polymerase chain reaction (PCR) amplification of DNA. This inhibition is due to the binding of sarafotoxin C with endothelin receptors on DNA, which prevents DNA polymerase from attaching. Endothelin-a receptor activity can also be inhibited by sarafotoxin C through enzymatic inactivation. Sarafot

Fórmula: C₁₀₃H₁₄₇N₂₇O₃₇S₅

Pureza: Min. 95%

Peso molecular: 2,515.76 g/mol

Ref: 3D-FS110267