CAS 1229194-11-9

Ethanodiamida, N1-(5-cloro-2-piridinil)-N2-[(1S,2R,4S)-4-[(dimetilamino)carbonil]-2-[[(4,5,6,7-tetrahidro-5-metiltiazolo[5,4-c]piridin-2-il)carbonil]amino]ciclohexil]-, 4-metilbencenosulfonato, hidrato (1:1:1)

Descripción:

Ethanodiamida, N1-(5-cloro-2-piridinil)-N2-[(1S,2R,4S)-4-[(dimetilamino)carbonil]-2-[[(4,5,6,7-tetrahidro-5-metiltiazolo[5,4-c]piridin-2-il)carbonil]amino]ciclohexil]-, 4-metilbencenosulfonato, hidrato (1:1:1) es un compuesto orgánico complejo caracterizado por su estructura multifuncional, que incluye un esqueleto de etanediamida y varios sustituyentes que contribuyen a su actividad biológica. La presencia de un grupo cloro y un anillo de piridina sugiere interacciones potenciales con objetivos biológicos, lo que lo hace de interés en la química medicinal. El compuesto también presenta una porción de tiazol, que a menudo se asocia con propiedades farmacológicas. El grupo sulfonato mejora su solubilidad en entornos acuosos, lo que es beneficioso para aplicaciones biológicas. Como un hidratado, contiene moléculas de agua que pueden influir en su estabilidad y solubilidad. En general, la intrincada estructura y los grupos funcionales de este compuesto indican una utilidad potencial en el desarrollo de fármacos, particularmente en la orientación a vías biológicas o receptores específicos. Se necesitarían más estudios para elucidar sus mecanismos de acción precisos y su potencial terapéutico.

Fórmula: C₂₄H₃₀ClN₇O₄S·C₇H₈O₃S·H₂O

InChI: InChI=1S/C24H30ClN7O4S.C7H8O3S.H2O/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23;1-6-2-4-7(5-3-6)11(8,9)10;/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34);2-5H,1H3,(H,8,9,10);1H2/t13-,15-,17+;;/m0../s1

Clave InChI: InChIKey=PSMMNJNZVZZNOI-SJILXJHISA-N

SMILES: N(C(=O)C1=NC2=C(S1)CN(C)CC2)[C@H]3[C@@H](NC(C(NC4=CC=C(Cl)C=N4)=O)=O)CC[C@H](C(N(C)C)=O)C3.S(=O)(=O)(O)C1=CC=C(C)C=C1.O

Sinónimos:

• Edoxaban Tosylate Monohydrate
• Edoxaban tosylate hydrate
• Edoxaban4-methylbenzenesulfonate, hydrate (1:1:1)
• Ethanediamide, N¹-(5-chloro-2-pyridinyl)-N²-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate (1:1:1)
• N-(5-Chloropyridin-2-yl)-N′-((1S,2R,4S)-4-[(dimethyl amino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl)ethanediamide p-toluenesulfonate monohydrate
• N-(5-Chloropyridin-2-yl)-N′-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]ethanediamide mono(p-toluenesulfonate) monohydrate
• Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate (1:1:1)
• Edoxaban tosylate monohydrate(for Edoxaban)

Ethanediamide, N1-(5-chloro-2-pyridinyl)-N2-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-, 4-methylbenzenesulfonate, hydrate (1:1:1)

CAS: 1229194-11-9

Fórmula: C₃₁H₄₀ClN₇O₈S₂

Pureza: %

Forma y color: Solid

Peso molecular: 738.2744

Ref: IN-DA000JRI

N1-(5-Chloropyridin-2-Yl)-N2-((1S,2R,4S)-4-(Dimethylcarbamoyl)-2-(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine-2-Carboxamido)Cyclohexyl)Oxalamide 4-Methylbenzenesulfonate Hydrate

CAS: 1229194-11-9

N1-(5-Chloropyridin-2-Yl)-N2-((1S,2R,4S)-4-(Dimethylcarbamoyl)-2-(5-Methyl-4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine-2-Carboxamido)Cyclohexyl)Oxalamide 4-Methylbenzenesulfonate Hydrate

Pureza: 98%

Peso molecular: 738.27g/mol

Ref: 54-OR1025692

Edoxaban Tosylate Monohydrate

CAS: 1229194-11-9

Edoxaban Tosylate Monohydrate

Pureza: ≥98%

Peso molecular: 738.27g/mol

Ref: 54-BUP13400

Edoxaban Tosylate Monohydrate

CAS: 1229194-11-9

Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.

Fórmula: C₃₁H₄₀ClN₇O₈S₂

Pureza: 99.86% - 99.91%

Forma y color: Solid

Peso molecular: 738.27

Ref: TM-T2368

Edoxaban Tosylate Hydrate

CAS: 1229194-11-9

Fórmula: C₂₄H₃₀ClN₇O₄SC₇H₈O₃SH₂O

Peso molecular: 548.06 : 172.2 : 18.0

Ref: ST-EA-CP-E8017

Edoxaban Tosylate Monohydrate

CAS: 1229194-11-9

Applications Edoxaban is an anticoagulant drug which acts as a direct factor Xa inhibitor.
References Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)

Fórmula: C₃₁H₃₈ClN₇O₇S₂•xH₂O

Forma y color: White To Off-White

Peso molecular: 720.26

Ref: TR-E555525

Edoxaban tosylate hydrate

CAS: 1229194-11-9

Edoxaban tosylate hydrate is an anticoagulant that inhibits the activity of thrombin and factor Xa. It has a long half-life and does not undergo significant first-pass metabolism in the liver. Edoxaban tosylate hydrate is used for the prevention of stroke in patients with atrial fibrillation. It can be administered orally or by intravenous infusion, and its effect is monitored by measuring levels of the natriuretic peptide NT-proBNP. Edoxaban tosylate hydrate has a low potential for drug interactions, which may be due to its low protein binding affinity (less than 10%). This drug also inhibits P-glycoprotein, which may lead to bleeding complications.

Fórmula: C₂₄H₃₀ClN₇O₄S·C₇H₈O₃S·H₂O

Pureza: Min. 95%

Peso molecular: 738.28 g/mol

Ref: 3D-EZB19411