CAS 123318-82-1

Clofarabina

Descripción:

Clofarabina es un análogo de nucleósido sintético utilizado principalmente en el tratamiento de la leucemia linfoblástica aguda (LLA) y la leucemia mieloide aguda (LMA). Se caracteriza por su estructura, que incluye una base purina y un grupo de azúcar, modificados para mejorar su eficacia y estabilidad. Clofarabina exhibe propiedades antineoplásicas al interferir con la síntesis y reparación del ADN, lo que lleva a la apoptosis en las células cancerosas. Su mecanismo de acción implica la inhibición de la ADN polimerasa y la ribonucleótido reductasa, que son cruciales para los procesos de replicación y reparación del ADN. El compuesto se administra típicamente por vía intravenosa y es conocido por sus posibles efectos secundarios, que incluyen mielosupresión, trastornos gastrointestinales e infecciones debido a la inmunosupresión. La farmacocinética de Clofarabina indica una vida media relativamente corta, lo que requiere un dosaje y monitoreo cuidadosos durante el tratamiento. En general, representa un avance significativo en las terapias dirigidas contra el cáncer, particularmente para pacientes con leucemia en recaída o refractaria.

Fórmula: C₁₀H₁₁ClFN₅O₃

InChI: InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1

Clave InChI: InChIKey=WDDPHFBMKLOVOX-AYQXTPAHSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3F)=NC(Cl)=N1

Sinónimos:

• 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
• 9H-Purin-6-amine, 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
• (2R,4R,5R)-5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
• 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
• 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
• 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
• Clolar
• 2-Chloro-9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)-9H-Purin-6-Amine
• 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
• CAFDA
• 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine
• Clofarabine
• 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
• Clofarex
• (2R,3R,4S,5S)-5-(4-amino-6-chloro-1H-benzo[d]imidazol-1-yl)-4-fluoro-2-(hydroxymethyl)-tetrahydrofuran-3-ol

Clofarabine

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 303.68

Ref: 3B-C2500

2-Chloro-2'-arabino-fluoro-2'-deoxyadenosine, 99+%

CAS: 123318-82-1

A purine nucleoside anti-metabolite. Toxic to nondividing lymphocytes and monocytes This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item c

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: 99+%

Peso molecular: 303.68

Ref: 02-J60927

Clofarabine

CAS: 123318-82-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₀H₁₁ClFN₅O₃

Forma y color: White Off-White Powder

Peso molecular: 303.05345

Ref: 45-1138620

Clofarabine System Suitability Mixture (This is a mixture containing clofarabine and clofarabine α anomer)

CAS: 123318-82-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Forma y color: White Solid

Ref: 45-1138621

(2R,3R,4S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 303.6774

Ref: IN-DA000KCJ

Clofarabine

CAS: 123318-82-1

Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: 99.94% - >99.99%

Forma y color: White Solid

Peso molecular: 303.68

Ref: TM-T0297

Clofarabine

CAS: 123318-82-1

Clofarabine

Pureza: ≥98%

Peso molecular: 303.68g/mol

Ref: 54-BUP15018

Clofarabine-13C-15N3

CAS: 123318-82-1

Fórmula: C₉₁₃CH₁₁ClFN₂₁₅N₃O₃

Forma y color: White To Off-White Solid

Peso molecular: 307.65

Ref: 4Z-C-11508

Clofarabine

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Peso molecular: 303.68

Ref: 7W-GP5199

Clofarabine

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Forma y color: White To Off-White Solid

Peso molecular: 303.68

Ref: 4Z-C-11501

Clofarabine, free base

CAS: 123318-82-1

Clofarabine, free base

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: By hplc: 99.9% (Typical Value in Batch COA)

Forma y color: white powder

Peso molecular: 303.68g/mol

Ref: 54-BIFK0045

Clofarabine

Producto controlado

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Forma y color: Neat

Peso molecular: 303.68

Ref: 86-MM3521.00

Clofarabine

CAS: 123318-82-1

Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),

Fórmula: C₁₀H₁₁ClFN₅O₃

Forma y color: White To Off-White

Peso molecular: 303.68

Ref: TR-C586890

Clofarabine

CAS: 123318-82-1

Clofarabine is FDA-approved for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children after at least two other types of treatment have failed

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: Min. 98 Area-%

Forma y color: White Off-White Powder

Peso molecular: 303.68 g/mol

Ref: 3D-NA07154

Clofarabine - Bio-X ™

CAS: 123318-82-1

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 303.68 g/mol

Ref: 3D-BC300153

CLOFARABINE

CAS: 123318-82-1

Fórmula: C₁₀H₁₁ClFN₅O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 303.68

Ref: 10-F387706