CAS 1234-35-1

Benzyloxi-carbonil-L-arginina

Descripción:

Benzyloxi-carbonil-L-arginina, comúnmente conocido como Z-Arg, es un derivado del aminoácido arginina, caracterizado por la presencia de un grupo protector benzyloxycarbonilo (Z). Este compuesto se utiliza a menudo en la síntesis de péptidos como un grupo protector para el grupo amino de la arginina, facilitando el acoplamiento selectivo de aminoácidos durante la formación de péptidos. El grupo Z mejora la estabilidad del aminoácido durante los procesos sintéticos, permitiendo la posterior desprotección en condiciones suaves. Benzyloxi-carbonil-L-arginina es típicamente un sólido cristalino blanco a blanco sucio, soluble en disolventes orgánicos como el dimetilsulfóxido (DMSO) y el metanol, pero menos soluble en agua. Su estructura molecular incluye un grupo guanidinio, que contribuye a su basicidad y reactividad. El compuesto es significativo en la investigación bioquímica y aplicaciones farmacéuticas, particularmente en el desarrollo de fármacos basados en péptidos y en el estudio de interacciones proteicas. El manejo y almacenamiento adecuados son esenciales, como con muchas sustancias químicas, para mantener su integridad y efectividad en entornos de laboratorio.

Fórmula: C₁₄H₂₀N₄O₄

InChI: InChI=1S/C14H20N4O4/c15-13(16)17-8-4-7-11(12(19)20)18-14(21)22-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,18,21)(H,19,20)(H4,15,16,17)/t11-/m0/s1

Clave InChI: InChIKey=SJSSFUMSAFMFNM-NSHDSACASA-N

SMILES: C(OC(N[C@@H](CCCNC(=N)N)C(O)=O)=O)C1=CC=CC=C1

Sinónimos:

• (2S)-2-[[(Benzyloxy)carbonyl]amino]-5-carbamimidamidopentanoic acid
• (2S)-5-(Diaminomethylideneazaniumyl)-2-(phenylmethoxycarbonylamino)pentanoate
• <span class="text-smallcaps">L</span>-Arginine, N²-[(phenylmethoxy)carbonyl]-
• <span class="text-smallcaps">L</span>-Arginine, N²-carboxy-, N-benzyl ester
• Arginine, N²-carboxy-, N-benzyl ester
• Arginine, N²-carboxy-, N²-benzyl ester, <span class="text-smallcaps">L</span>-
• Benzyloxycarbonyl-<span class="text-smallcaps">L</span>-arginine
• BenzyloxycarbonylLarginine
• Cbz-L-arginine
• N(alpha)-Benzyloxycarbonyl-L-arginine~Z-Arg-OH
• N(alpha)-Cbz-L-arginine
• N(alpha)-Z-L-arginine
• N-2-carbobenzyloxy-L-arginine
• N-Carbobenzoxyarginine
• N²-Benzyloxycarbonyl-<span class="text-smallcaps">L</span>-arginine
• N²-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-arginine
• N^α-(Benzyloxycarbonyl)arginine
• NALPHA-Benzyloxycarbonyl-L-arginine
• Na-Benzyloxycarbonyl-L-arginine
• Nalpha-CBZ-L-Arginine
• N~2~-[(benzyloxy)carbonyl]-N~5~-(diaminomethylidene)-L-ornithine
• Z-Arg
• Z-Arg-OH
• Z-L-Arg-OH
• na-cbz-L-arginine free acid
• N2-[(Phenylmethoxy)carbonyl]-L-arginine
• Arginine, N2-carboxy-, N2-benzyl ester, L-
• L-Arginine, N2-carboxy-, N-benzyl ester
• Arginine, N2-carboxy-, N-benzyl ester

L-Arginine, N2-[(phenylmethoxy)carbonyl]-

CAS: 1234-35-1

Fórmula: C₁₄H₂₀N₄O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 308.3330

Ref: IN-DA000KIQ

Nα-Cbz-L-Arginine

CAS: 1234-35-1

Nα-Cbz-L-Arginine

Pureza: 97%

Peso molecular: 308.33g/mol

Ref: 54-OR1014244

Z-Arg-OH

CAS: 1234-35-1

Fórmula: C₁₄H₂₀N₄O₄

Pureza: ≥ 98.0%

Forma y color: White powder

Peso molecular: 308.34

Ref: 7W-GM5373

Nα-Carbobenzoxy-L-arginine

CAS: 1234-35-1

Fórmula: C₁₄H₂₀N₄O₄

Pureza: >97.0%(T)

Forma y color: White to Almost white powder to crystal

Peso molecular: 308.34

Ref: 3B-C0757

Z-L-Arg-OH

CAS: 1234-35-1

Z-L-Arg-OH is a peptide hormone that belongs to the group of peptide hormones. It has been shown to have a stabilizing effect on hydrolysis reactions and its ph optimum is between 6.0 and 7.5. Amino acid analysis has shown that this molecule contains two amino acids, L-arginine as the first amino acid and L-arginine as the last amino acid. The trifluoroacetic acid (TFA) catalyses the hydrolysis reaction at a rate that is much faster than other acids such as phosphoric acid or nitric acid. Kinetic studies have been done using soybean trypsin enzyme preparations and Z-L-Arg-OH shows an increase in activity with higher concentrations of trypsin. Enzyme preparations show an increase in activity for Z-L-Arg-OH when it is mixed with another enzyme such as pepsin or papain. Acid analysis also showed that Z-

Fórmula: C₁₄H₂₀N₄O₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 308.34 g/mol

Ref: 3D-FA33481

Z-Arg-OH

CAS: 1234-35-1

M03028 - Z-Arg-OH

Fórmula: C₁₄H₂₀N₄O₄

Pureza: 98%

Forma y color: Solid, No data available.

Peso molecular: 308.338

Ref: 10-M03028

Z-L-Arginine extrapure, 99%

CAS: 1234-35-1

Fórmula: C₁₄H₂₀N₄O₄

Pureza: min. 99%

Forma y color: White to off-white, Crystalline powder

Peso molecular: 308.3

Ref: SR-60020

Z-L-Arginine

Producto controlado

CAS: 1234-35-1

Applications Z-L-Arginine is used in the synthesis of renin inhibitors containing phosphorous acid derivatives at the scissile bond. Also used in the synthesis of a peptide deformylase inhibitor BB-3497.
References Allen, M. et al.: J. Med. Chem., 32, 1652 (1989); Davies, S. et al.: Bioorg. Med. Chem. Lett., 13, 2715 (2003);

Fórmula: C₁₄H₂₀N₄O₄

Forma y color: Neat

Peso molecular: 308.33

Ref: TR-A769400