CAS 123524-52-7

Azelnidipina

Descripción:

Azelnidipina es un bloqueador de canales de calcio utilizado principalmente en el tratamiento de la hipertensión. Pertenece a la clase de compuestos dihidropiridínicos, que se caracterizan por su capacidad para inhibir la entrada de calcio a través de los canales de calcio tipo L en el músculo liso vascular y el tejido cardíaco. Esta acción conduce a la vasodilatación y a una posterior reducción de la presión arterial. Azelnidipina es conocido por su larga vida media, lo que permite una dosificación una vez al día, lo que mejora la adherencia del paciente. El compuesto exhibe selectividad por los tejidos vasculares sobre los tejidos cardíacos, minimizando los efectos secundarios potenciales como la taquicardia refleja. Además, tiene propiedades antioxidantes, que pueden proporcionar beneficios cardiovasculares adicionales. Azelnidipina se administra típicamente en su forma de sal hidrocloruro y se absorbe bien en el tracto gastrointestinal. Su farmacocinética puede verse influenciada por la ingesta de alimentos, y se metaboliza principalmente en el hígado. En general, Azelnidipina representa una opción valiosa en la terapia antihipertensiva, particularmente para pacientes que requieren un manejo a largo plazo de la hipertensión arterial alta.

Fórmula: C₃₃H₃₄N₄O₆

InChI: InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3

Clave InChI: InChIKey=ZKFQEACEUNWPMT-UHFFFAOYSA-N

SMILES: C(OC1CN(C(C2=CC=CC=C2)C3=CC=CC=C3)C1)(=O)C=4C(C(C(OC(C)C)=O)=C(C)NC4N)C5=CC(N(=O)=O)=CC=C5

Sinónimos:

• 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) 5-isopropyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl)-5-(1-methylethyl) esster, (+-)-
• 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-
• 3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• 3-O-(1-Benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 3-[1-(Diphenylmethyl)Azetidin-3-Yl] 5-Propan-2-Yl 2-Amino-6-Methyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• Calblock
• Ccris 8650
• Cs 905
• Unii-Pv23P19Yug

3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester

CAS: 123524-52-7

Fórmula: C₃₃H₃₄N₄O₆

Pureza: 97%

Forma y color: Solid

Peso molecular: 582.6463

Ref: IN-DA000KQ9

Azelnidipine

CAS: 123524-52-7

Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.

Fórmula: C₃₃H₃₄N₄O₆

Pureza: 99.78%

Forma y color: Light Yellowish Powder

Peso molecular: 582.65

Ref: TM-T0121

Azelnidipine

CAS: 123524-52-7

Fórmula: C₃₃H₃₄N₄O₆

Forma y color: Light Yellow Solid

Peso molecular: 582.66

Ref: 4Z-A-10101

Azelnidipine

CAS: 123524-52-7

Azelnidipine

Pureza: ≥98%

Peso molecular: 582.65g/mol

Ref: 54-BUP13584

Azelnidipine

CAS: 123524-52-7

Azelnidipine

Pureza: 99%

Peso molecular: 582.65g/mol

Ref: 54-OR1028132

Azelnidipine-d7

CAS: 123524-52-7

Fórmula: C₃₃H₂₇D₇N₄O₆

Forma y color: Yellow Solid

Peso molecular: 589.70

Ref: 4Z-A-10102

Azelnidipine

CAS: 123524-52-7

Fórmula: C₃₃H₃₄N₄O₆

Pureza: >98.0%(T)(HPLC)

Forma y color: Light orange to Yellow to Green powder to crystal

Peso molecular: 582.66

Ref: 3B-A2433

Azelnidipine

CAS: 123524-52-7

Fórmula: C₃₃H₃₄N₄O₆

Pureza: (HPLC) ≥ 98.0%

Forma y color: Off-white to light yellow powder

Peso molecular: 582.65

Ref: 7W-GP5829

Azelnidipine

CAS: 123524-52-7

Azelnidipine is a drug that is used to treat high blood pressure and heart disease. It reduces the risk of cardiovascular events such as myocardial infarction and stroke. Azelnidipine has been shown to have an antioxidative effect, which may be due to its ability to decrease lipid peroxidation, increase superoxide dismutase activity, and inhibit the production of reactive oxygen species in a model of tubulointerstitial injury. The drug also inhibits calcium influx into cells by interfering with voltage-gated calcium channels. Azelnidipine binds reversibly to α1-acid glycoprotein, which is found in plasma and erythrocytes. This interaction may result in changes in renal function when combined with other drugs that bind the same protein (e.g., warfarin).

Fórmula: C₃₃H₃₄N₄O₆

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 582.65 g/mol

Ref: 3D-FA18072

Azelnidipine

Producto controlado

CAS: 123524-52-7

Applications Azelnidipine is a dihydropyridine calcium channel blocker with antihypertensice activity. Azelnidipine is used for treating ischemic heart disease and cardiac remodeling after myocardial infarction. Studies show that Azelnidipine ttreatment can reduce the risk of hyperglycemia induced metabolic disorders
References Sugimoto, K. et al.: Int. J. Hypertens., No pp. (2010); Kain, V. et al.: Cardio. Diabetol., 9, 82 (2010); Kinouchi, K. et al.: Int. J. Hypertens., 284823, 11 (2011);

Fórmula: C₃₃H₃₄N₄O₆

Forma y color: Yellow

Peso molecular: 582.65

Ref: TR-A808500