CAS 123884-00-4

Dolastatina 15

Descripción:

Dolastatina 15 es un péptido potente derivado del molusco marino Dolabella auricularia, conocido por sus significativas propiedades antitumorales. Este compuesto se caracteriza por su estructura compleja, que incluye una serie de aminoácidos que contribuyen a su actividad biológica. Dolastatina 15 exhibe un mecanismo de acción único, principalmente al inhibir la ensamblaje de microtúbulos, interrumpiendo así la formación del huso mitótico durante la división celular. Esta acción lo convierte en un candidato para el tratamiento del cáncer, particularmente en el objetivo de varios tipos de tumores. La sustancia también se destaca por su alta potencia y especificidad, lo que puede llevar a una reducción de los efectos secundarios en comparación con los agentes quimioterapéuticos tradicionales. Además, Dolastatina 15 ha sido objeto de una extensa investigación para explorar su potencial en el desarrollo de fármacos, aunque su aplicación clínica aún está bajo investigación. Su estabilidad, solubilidad y biodisponibilidad son factores críticos que influyen en su eficacia terapéutica y formulación en contextos farmacéuticos. En general, Dolastatina 15 representa una vía prometedora en la búsqueda de terapias efectivas contra el cáncer.

Fórmula: C₄₅H₆₈N₆O₉

InChI: InChI=1/C45H68N6O9/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30/h13-15,18-19,25-29,31-33,36-39H,16-17,20-24H2,1-12H3,(H,46,53)/t31-,32-,33-,36-,37-,38-,39-/m0/s1

SMILES: CC(C)[C@@H](C(=O)N(C)[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc2)C(=CC1=O)OC)N=C([C@H](C(C)C)N(C)C)O

Sinónimos:

• (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
• (2S)-1-[(2S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl N-methyl-L-valyl-L-prolyl-2-{(2S)-2-[(N,N-dimethyl-L-valyl)amino]-3-methylbutanoyl}-L-prolinate
• 1-(2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-methyl-1-oxobutan-2-yl N,N-dimethylvalylvalyl-N-methylvalylprolylprolinate
• (1S)-1-{[(2S)-2-benzyl-3-methoxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]carbonyl}-2-methylpropyl N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-prolinate
• DOLASTATIN 15
• L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
• L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-propyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
• Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline
• (5S)-1-[(2S)-O-(N,N-VAL-VAL-N-ME-VAL-PRO-PRO)-2-HYDROXYISOVALERYL]-2-OXO-4-METHOXY-5-BENZYL-3-PYRROLINE
• (5S)-1-[N,N-Dimethyl-L-Val-L-Val-N-methyl-L-Val-L-Pro-L-Pro-L-Hyiv-]-5-benzyl-4-methoxy-1H-pyrrol-2(5H)-one
• Nsc 617668

Dolastatin 15

CAS: 123884-00-4

Dolastatin 15 originally isolated from the sea hare Dolabella auricularia belongs to a family of antimitotic and antineoplastic depsipeptides inducing apoptosis in various malignant cell types. It was shown to inhibit the growth of the P388 lymphocytic leukemia cell line efficiently, with an ED₅₀ value of 2.4 ng/mL.

Fórmula: C₄₅H₆₈N₆O₉

Pureza: 98.7%

Forma y color: White Powder

Peso molecular: 837.07

Ref: 01-4019226

L-Proline, N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-, (1S)-1-[[(2S)-2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl]carbonyl]-2-methylpropyl ester

CAS: 123884-00-4

Fórmula: C₄₅H₆₈N₆O₉

Pureza: 98%

Forma y color: Solid

Peso molecular: 837.0562

Ref: IN-DA000L75

Dolastatin 15

CAS: 123884-00-4

Dolastatin 15, depsipeptide from Dolabella auricularia, is an ADC cytotoxin that induces apoptosis in myeloma cells.

Fórmula: C₄₅H₆₈N₆O₉

Pureza: 98%

Forma y color: Solid

Peso molecular: 837.072

Ref: TM-T15158

Dolastatin 15

CAS: 123884-00-4

Fórmula: C₄₅H₆₈N₆O₉

Pureza: ≥ 95.0%

Forma y color: White powder

Peso molecular: 837.06

Ref: 7W-GP8277

Dolastatin 15

Producto controlado

CAS: 123884-00-4

Fórmula: C₄₅H₆₈N₆O₉

Forma y color: Neat

Peso molecular: 837.056

Ref: TR-D528508

Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzyl-3-pyrroline

CAS: 123884-00-4

Dolastatin 15 (5S)-1-[(2S)-O-(N,N-Dimethyl-Val-Val-N-Me-Val-Pro-Pro)-2-hydroxyisovaleryl]-2-oxo-4-methoxy-5-benzylpyrrolidinium is a natural compound that has been isolated from the Indian Ocean sea hare Dolabella auricularia. It has shown significant cytotoxicity against cancer cells as well as significant immunosuppressive activities in animals. Dolastatin 15 is an analog of dolastatin 10 and has been shown to be active against hepatitis B and C virus. It also has antiinflammatory properties and may be effective in combating autoimmune diseases. The synthesis of this compound is an asymmetric synthesis with a hydroxyl group on one side of the molecule and an amide on the other side.

Fórmula: C₄₅H₆₈N₆O₉

Pureza: Min. 95%

Peso molecular: 837.06 g/mol

Ref: 3D-FD110329