CAS 124485-41-2

Z-Val-Val-Arg-AMC

Descripción:

Z-Val-Val-Arg-AMC, también conocido como Z-Val-Val-Arginina-7-amido-4-metilcumarina, es un sustrato peptídico sintético comúnmente utilizado en investigación bioquímica, particularmente en el estudio de proteasas. La "Z" en su nombre indica que es un derivado de benzyloxycarbonilo, que sirve para proteger el grupo amino de la valina N-terminal, mejorando su estabilidad y solubilidad. La estructura presenta una secuencia de aminoácidos, incluyendo valina y arginina, vinculados a un moiety de 7-amido-4-metilcumarina, que actúa como un reportero fluorescente. Este compuesto se emplea a menudo en ensayos para monitorear la actividad proteolítica, ya que la ruptura del enlace peptídico por enzimas específicas libera la cumarina fluorescente, permitiendo la cuantificación. Sus características incluyen alta especificidad para ciertas proteasas, buena solubilidad en soluciones acuosas y la capacidad de proporcionar monitoreo en tiempo real de reacciones enzimáticas. En general, Z-Val-Val-Arg-AMC es una herramienta valiosa en la enzimiología y campos relacionados para estudiar la cinética y mecanismos enzimáticos.

Fórmula: C₃₄H₄₅N₇O₇

Z-Val-Val-Arg-AMC · HCl

CAS: 124485-41-2

Z-Val-Val-Arg-AMC · HCl is a substrate of human and canine cathepsin S. Z-Val-Val-Arg-AMC · HCl is also cleaved by falcipain-related enzymes from Plasmodium species.

Fórmula: C₃₄H₄₅N₇O₇·HCl

Pureza: > 99%

Forma y color: White Powder

Peso molecular: 700.22

Ref: 01-4016422

Z-Val-Val-Arg-AMC

CAS: 124485-41-2

Z-Val-Val-Arg-AMC serves as a fluorescent peptide substrate utilized for assessing the activity of cathepsins [1].

Fórmula: C₃₄H₄₅N₇O₇

Forma y color: Solid

Peso molecular: 663.76

Ref: TM-T87681

Z-Val-Val-Arg-AMC

CAS: 124485-41-2

Z-Val-Val-Arg-AMC is a protease inhibitor that inhibits the activity of the ubiquitin-proteasome pathway. It was first synthesized in an attempt to inhibit the activity of cathepsin B, but it was found to inhibit other proteases and is now used as a research reagent. Z-Val-Val-Arg-AMC has been shown to have pharmacokinetic properties similar to those of zwitterionic drugs, which may be due to its high degree of water solubility. This drug also has antiinflammatory and antiproteolytic effects and may have potential use in the treatment of cancer and autoimmune diseases. Z-Val-Val-Arg-AMC inhibits autophagy by inhibiting lysosomal degradation mediated by autophagy protein LC3B and plays a role in apoptosis.

Fórmula: C₃₄H₄₅N₇O₇

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 663.76 g/mol

Ref: 3D-FV49239

Z-Val-Val-Arg-AMC

CAS: 124485-41-2

Z-Val-Val-Arg-AMC is a synthetic peptide that activates the glycine receptor. It has been shown to inhibit ion channel function in a rat model of epilepsy, and also to block the binding of an antibody against the glycine receptor. The peptide was synthesized by coupling L-valine, L-valylglycine, and L-arginine with methyl 2-(4'-methylaminophenyl) acetate. Z-Val-Val-Arg-AMC is a high purity product that has been shown to be useful in cell biology research as a tool for studying ligand/receptor interactions.

Fórmula: C₃₄H₄₅N₇O₇

Pureza: Min. 95%

Peso molecular: 663.76 g/mol

Ref: 3D-MCA-3211-V