CAS 125-65-5

Pleuromutilina

Descripción:

Pleuromutilina es un antibiótico natural derivado del hongo *Pleurotus mutilus*. Pertenece a la clase de compuestos conocidos como Pleuromutilinas, que se caracterizan por su estructura única que incluye un sistema de anillo tetracíclico. Este antibiótico exhibe actividad de amplio espectro contra varias bacterias Gram-positivas y algunas bacterias Gram-negativas, lo que lo hace efectivo en el tratamiento de infecciones causadas por cepas resistentes. Pleuromutilina funciona inhibiendo la síntesis de proteínas bacterianas, dirigiéndose específicamente al centro de transferencia peptidílica del ribosoma, lo que interrumpe el proceso de traducción. Su bajo perfil de toxicidad y eficacia han llevado a su desarrollo para uso clínico, particularmente en el tratamiento de infecciones de piel y tejidos blandos. Además, Pleuromutilina ha sido modificado para crear derivados semisintéticos, como la retapamulina, que se utilizan en formulaciones tópicas. La sustancia se administra típicamente de manera controlada, y su farmacocinética se ve influenciada por factores como la formulación y la vía de administración. En general, Pleuromutilina representa un avance significativo en la terapia antibiótica, especialmente frente al aumento de la resistencia a los antibióticos.

Fórmula: C₂₂H₃₄O₅

InChI: InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13-,14+,16-,18+,19+,20-,21+,22+/m1/s1

Clave InChI: InChIKey=ZRZNJUXESFHSIO-BKUNHTPHSA-N

SMILES: C[C@@H]1[C@]23[C@]([C@](C)([C@H](OC(CO)=O)C[C@](C=C)(C)[C@H]1O)[C@H](C)CC2)(C(=O)CC3)[H]

Sinónimos:

• (3aS,4R,5S,6S,8R,9S,9aR,10S)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate
• 14-Deoxy-14-[(hydroxyacetyl)oxy]mutilin
• 3a,9-Propano-3aH-cyclopentacyclooctene, acetic acid deriv.
• 6-Ethenyl-5-Hydroxy-4,6,9,10-Tetramethyl-1-Oxodecahydro-3A,9-Propanocyclopenta[8]Annulen-8-Yl Hydroxyacetate
• Acetic acid, 2-hydroxy-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, hydroxy-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, hydroxy-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, [3aS-(3aα,4β,5α,6α,8β,9α,9aβ,10S*)]-
• Antibiotic A 40104C
• Bc 757
• Drosophilin B
• Glycolic acid, 8-ester with octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1(4H)-one
• Mutilin 14-glycolate
• NSC 121145

Pleuromutilin

CAS: 125-65-5

Pureza: 98%

Forma y color: Solid

Peso molecular: 378.509

Ref: 10-F987727

VALNEMULIN IMPURITY E CRS

CAS: 125-65-5

VALNEMULIN IMPURITY E CRS

Fórmula: C₂₂H₃₄O₅

Peso molecular: 378.5024

Ref: 41-Y0000586

Acetic acid, hydroxy-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Pureza: 90%

Forma y color: Solid

Peso molecular: 378.5024

Ref: IN-DA00HHVG

Pleuromutilin

CAS: 125-65-5

Pleuromutilin

Pureza: ≥98%

Peso molecular: 378.5g/mol

Ref: 54-BUP14420

Tiamulin EP Impurity G (Valnemulin EP Impurity E)

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Peso molecular: 378.51

Ref: 4Z-T-9410

Pleuromutilin

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Pureza: ≥ 95.0%

Forma y color: White to off-white or light yellow solid

Peso molecular: 378.5

Ref: 7W-GA2930

(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopentacycloocten-8-yl Hydroxyacetate (Pleuromutilin)

Producto controlado

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Forma y color: Neat

Peso molecular: 378.50

Ref: 86-MM0394.10

Pleuromutilin

CAS: 125-65-5

Pleuromutilin (Drosophilin B) is an inhibitor of bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.

Fórmula: C₂₂H₃₄O₅

Pureza: 97.321%

Forma y color: Crystalline Solid

Peso molecular: 378.5

Ref: TM-T16552

Pleuromutilin

Producto controlado

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Forma y color: Neat

Peso molecular: 378.50

Ref: TR-P610500

Pleuromulin

CAS: 125-65-5

The compound 5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate is an antimicrobial agent that inhibits bacterial growth by binding to the disulfide bond of bacterial peptidoglycan. It is effective against a wide range of microorganisms including MRSA and methicillin resistant Enterococcus faecalis. The compound has shown efficacy in an animal model of chronic bronchitis caused by Streptococcus pneumoniae. The compound has a short half life and can be administered orally or intravenously with a pharmacokinetic profile that depends on the dose. This drug also has high resistance to β lactamase enzymes, which are found in some bacteria such as E. coli.

Fórmula: C₂₂H₃₄O₅

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 378.5 g/mol

Ref: 3D-FP27100

Pleuromulin - Bio-X ™

CAS: 125-65-5

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₂H₃₄O₅

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 378.5 g/mol

Ref: 3D-BH300113

Tiamulin EP Impurity G

CAS: 125-65-5

Fórmula: C₂₂H₃₄O₅

Peso molecular: 378.51

Ref: ST-EA-CP-T154005