CAS 125317-39-7

Navelbine

Descripción:

Navelbine, conocido por su nombre genérico vinorelbine, es un alcaloide de vinca semisintético derivado de la planta de vincapervinca, Catharanthus roseus. Se utiliza principalmente como agente quimioterapéutico en el tratamiento de varios tipos de cáncer, incluyendo cáncer de pulmón de células no pequeñas y cáncer de mama. Vinorelbine funciona inhibiendo la formación de microtúbulos durante la división celular, interrumpiendo así el huso mitótico y llevando a la detención del ciclo celular y apoptosis en células cancerosas que se dividen rápidamente. El compuesto se administra típicamente por vía intravenosa y tiene un perfil de efectos secundarios moderado, que puede incluir neutropenia, náuseas y fatiga. Su farmacocinética implica metabolismo hepático, principalmente a través del sistema del citocromo P450, y se excreta principalmente en la bilis. El número CAS 125317-39-7 identifica de manera única a vinorelbine en bases de datos químicas, facilitando la investigación y aplicaciones clínicas. En general, Navelbine representa una opción terapéutica importante en oncología, contribuyendo a mejorar los resultados en pacientes con malignidades específicas.

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

InChI: InChI=1S/C45H54N4O8.C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;1-2,5-6H,(H,7,8)(H,9,10)/t28-,37-,38+,39+,42+,43+,44-,45-;1-,2-/m01/s1

Clave InChI: InChIKey=UUHYRRXICWUZHW-RPZOAHRESA-N

SMILES: C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)C[N@@]9C[C@](C6)(C=C(CC)C9)[H])[H])CCN3CC=C2)[H].[C@@H]([C@H](C(O)=O)O)(C(O)=O)O

Sinónimos:

• (3Ar,3A1R,4R,5S,5Ar,10Br)-Methyl 4-Acetoxy-3A-Ethyl-9-((2S,6S,8S)-4-Ethyl-8-(Methoxycarbonyl)-1,3,6,7,8,9-Hexahydro-2,6-Methanoazecino[4,3-B]Indol-8-Yl)-5-Hydroxy-8-Methoxy-6-Methyl-3A,3A1,4,5,5A,6,11
• 3',4'-Didehydro-4'-Deoxy-C'-Norvincaleukoblastine
• 3',4'-didehydro-4'-deoxy-c'-norvincaleukoblastine R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt
• 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine tartrate
• 5'-Noranhydrovinoblastine Tartrate
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Bitartrate
• Butanedioate(1:2)
• C'-norvincaleukoblastine,3',4'-didehydro-4'-dioxy-,(R-(R*,R*))-2,3-dihydroxy
• C′-Norvincaleukoblastine, 3′,4′-didehydro-4′-deoxy-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt)
• Kw 2307
• Navelbine
• Navelbine ditartrate
• Navelbine tartrate
• Nor-5′-anhydrovinblastine ditartrate
• Nvb
• Pacilitaxel
• Vinorelbin
• Vinorelbine bitartrate
• Vinorelbine bitratrate
• Vinorelbine ditartaric acid
• Vinorelbine ditartrate salt
• Vinorelbine tartarate
• Vinorelbine tartrate
• Vinorelbine tartrate usp standard
• Vinorelbineditartrate salt hydrate
• [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt]
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)

VINORELBINE FOR PEAK IDENTIFICATION A CRS

CAS: 125317-39-7

VINORELBINE FOR PEAK IDENTIFICATION A CRS

Forma y color: Powder

Ref: 41-Y0001938

VINORELBINE TARTRATE CRS

CAS: 125317-39-7

VINORELBINE TARTRATE CRS

Fórmula: C₄₅H₅₄N₄O₈

Forma y color: Powder

Peso molecular: 778.9323

Ref: 41-Y0000463

VINORELBINE FOR PEAK IDENTIFICATION B CRS

CAS: 125317-39-7

VINORELBINE FOR PEAK IDENTIFICATION B CRS

Forma y color: Powder

Ref: 41-Y0001939

Vinorelbine Tartrate

CAS: 125317-39-7

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Forma y color: Powder

Peso molecular: 778.39416

Ref: 45-1714506

Vinorelbine Ditartrate

CAS: 125317-39-7

Fórmula: C₅₃H₆₆N₄O₂₀

Pureza: 98%

Forma y color: Solid

Peso molecular: 1079.1059

Ref: IN-DA00HI66

Vinorelbine Ditartrate Salt

CAS: 125317-39-7

Vinorelbine Ditartrate Salt

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Pureza: 98%

Forma y color: white to off-white solid

Peso molecular: 1,079.11g/mol

Ref: 54-BIFK0008

Vinorelbine ditartrate

CAS: 125317-39-7

Vinorelbine ditartrate

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Pureza: ≥98%

Peso molecular: 1079.11

Ref: 54-BUP13274

Vinorelbine Ditartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Forma y color: White To Off-White Solid

Peso molecular: 778.95 2*150.09

Ref: 4Z-V-040001

Vinorelbine Ditartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Pureza: >95.0%(T)(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 1,079.12

Ref: 3B-V0151

Vinorelbine Tartrate

Producto controlado

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈C₄H₆O₆

Forma y color: White

Peso molecular: 1079.11

Ref: 86-MM1252.00

Vinorelbine Tartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈•2C₄H₆O₆

Pureza: 95%~99%

Peso molecular: 1079.11

Ref: BP-BP1446

Vinorelbine ditartrate

CAS: 125317-39-7

Methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((8R)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate bi

Fórmula: C₅₃H₆₆N₄O₂₀

Pureza: 98%

Peso molecular: 1079.11

Ref: IN-DG156447

Vinorelbine ditartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆·xH₂O

Pureza: (HPLC) ≥ 98.0% (dried basis)

Forma y color: White to off-white powder

Peso molecular: 1079.11 (anhydrous)

Ref: 7W-GP5205

Vinorelbine ditartrate

CAS: 125317-39-7

Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor activity. Cost-effective and quality-assured.

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Pureza: 98% - 99.93%

Forma y color: Solid

Peso molecular: 1079.11

Ref: TM-T6213

Vinorelbine-d3 Bitartrate

Producto controlado

CAS: 125317-39-7

Stability Light Sensitive, Temperature Sensitive
Applications An antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mathe, G., et al.: Cancer Letters, 27, 285 (1985), Levegue, D., et al.: Clin. Pharmacokinet., 31, 184 (1996), Curran, M.P., et al.: Drugs Aging., 19, 695 (2002),

Fórmula: C₅₃H₆₃D₃N₄O₂₀

Forma y color: Neat

Peso molecular: 1082.12

Ref: TR-V315002

Vinorelbine tartrate - Bio-X ™

Producto controlado

CAS: 125317-39-7

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₅₃H₆₆N₄O₂₀

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 1,079.11 g/mol

Ref: 3D-BV300138

Vinorelbine tartrate

Producto controlado

CAS: 125317-39-7

Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid

Fórmula: C₅₃H₆₆N₄O₂₀

Pureza: (Hplc) Min. 98.0%

Forma y color: White Powder

Peso molecular: 1,079.11 g/mol

Ref: 3D-FV61484

Vinorelbine ditartrate

CAS: 125317-39-7

Ref: BE-RMCV071001

Vinorelbine Bitartrate

Producto controlado

CAS: 125317-39-7

Stability Temperature Sensitive
Applications An antineoplastic.
References Mathe, G., et al.: Cancer Letters, 27, 285 (1985), Levegue, D., et al.: Clin. Pharmacokinet., 31, 184 (1996), Curran, M.P., et al.: Drugs Aging., 19, 695 (2002),

Fórmula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Forma y color: Neat

Peso molecular: 1079.11

Ref: TR-V315000

Vinorelbine Ditartrate

CAS: 125317-39-7

Fórmula: C₄₅H₅₄N₄O₈(C₄H₆O₆)

Peso molecular: 778.95 : 2(150.09)

Ref: ST-EA-CP-V49001