CAS 1263-89-4

Sulfato de paromomicina

Descripción:

Sulfato de paromomicina es un antibiótico aminoglucósido que se utiliza principalmente para tratar infecciones causadas por ciertos tipos de bacterias, particularmente en casos de amebiasis intestinal y leishmaniasis. Se deriva de la bacteria Streptomyces griseus y funciona inhibiendo la síntesis de proteínas en microorganismos susceptibles. El compuesto se caracteriza por su capacidad para unirse a la subunidad ribosomal 30S, lo que lleva a una lectura errónea del ARNm y, en última instancia, interrumpe el crecimiento bacteriano. La paromomicina se administra típicamente por vía oral o parenteral, dependiendo de la infección que se esté tratando. Se conoce por su toxicidad relativamente baja en comparación con otros aminoglucósidos, aunque aún puede causar efectos secundarios como trastornos gastrointestinales y nefrotoxicidad en algunos casos. La forma sulfato mejora su solubilidad en agua, lo que la hace adecuada para diversas formulaciones. La paromomicina también se está investigando por su posible uso en el tratamiento de infecciones multirresistentes, destacando su importancia en el campo de la terapia antimicrobiana.

Fórmula: C₂₃H₄₇N₅O₁₈S

InChI: InChI=1/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23?;/m1./s1

Clave InChI: InChIKey=LJRDOKAZOAKLDU-UDXJMMFXSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N

Sinónimos:

• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside sulfate (salt)
• (2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• 1600 Antibiotic
• 4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxyhexopyranosyl)-D-lyxofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxyhexopyranoside sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D</span>-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
• Aminosidin sulfate
• Aminosidin sulphate
• Aminosidine Sulphate
• Aminosidine sulfate
• Aminoxidin
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (1:?)
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
• Farmiglucin
• Farminosidin
• Fi 5853
• Gabbroral
• Humagel
• Humatin
• Humycin sulfate
• O-2-Amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptamine sulfate (salt)
• Paramicina
• Pargonyl
• Paricina
• Paromomycin Sulphate
• Paromomycin Sulphates
• Paromomycin sulfate salt
• Paromomycinsulfate
• Sinosid
• Sulfates De Paromomycine
• Sulfatos De Paromomicina
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• Paromomycin sulfate
• D-Streptamine, O-2-amino-2-deoxy-a-D-glucopyranosyl-(14)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-b-D-ribofuranosyl-(15)]-2-deoxy-, sulfate (salt) (9CI)
• fi5853
• PayoMoMycin Sulfate
• Paromomycin sulphate solution,1000ppm solution
• Barone sulfate kanamycin Solution, 100ppm
• humycinsulfate
• Humatin (tn)
• Paromomycin sulfate (jan/usp)
• O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate
• sulf
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-O-b-D-ribofuranosyl-(15)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(14)]-2-deoxy-, sulfate (salt) (8CI)
• Paromomycin sulphate solution,100ppm
• aminosidinesulfate
• PAROMOMYCIN SULFATE CELL CULTURE REAGENT 97+%
• Paromomycin Sulfate (125 mg)
• paromomycin sulfate cell culture tested
• Paromomycin Sufate
• paromomycin sulfate plant cell*culture tested
• streptamine,o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribof
• NEOMYCIN E
• aminosidinesulphate
• Paramomycinsulfate
• O-2,6-DiaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-aMino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-StreptaMine Sulfate
• aminosidinsulfate
• O-2-AMino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptaMine Sulfate
• D00868
• PAROMOMYCIN SULFATE USP 97+%
• Paromomycin sulfate ,98%
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1)

Paromomycin Sulfate

CAS: 1263-89-4, 7542-37-2, 84420-34-8

Fórmula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Pureza: >92.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Ref: 3B-P2092

Paromomycin sulfate

CAS: 1263-89-4

Inhibits initiation and elongation during protein synthesis

Fórmula: C₂₃H₄₇N₅O₁₈S

Forma y color: White to pale cream to pale yellow, Powder

Peso molecular: 713.71

Ref: 02-J61274

PAROMOMYCIN SULFATE RS

CAS: 1263-89-4

PAROMOMYCIN SULFATE RS

Fórmula: C₂₃H₄₅N₅O₁₄

Peso molecular: 615.6285

Ref: 41-ICRS0378

Paromomycin Sulfate

CAS: 1263-89-4

Aminoglycoside antibiotics

Fórmula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Forma y color: White Off-White Light Yellow Powder

Peso molecular: 615.2963

Ref: 45-1500003

Paromomycin sulfate

CAS: 1263-89-4

Fórmula: C₂₃H₄₇N₅O₁₈S

Pureza: 98%

Forma y color: Solid

Peso molecular: 713.7070

Ref: IN-DA0072SF

Paromomycin Sulfate

CAS: 1263-89-4

Paromomycin Sulfate, an aminoglycoside antibiotic, binds to 30S ribosomes, disrupting protein synthesis and killing bacteria.

Fórmula: C₂₃H₄₇N₅O₁₈S

Pureza: 99.73% - 99.86%

Forma y color: Solid

Peso molecular: 713.71

Ref: TM-T1104

Paromomycin Sulfate

CAS: 1263-89-4

Paromomycin Sulfate

Pureza: ≥98%

Peso molecular: 713.71g/mol

Ref: 54-BUP18626

Paromomycin sulfate salt

CAS: 1263-89-4

Fórmula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Forma y color: White to off-white powder

Peso molecular: 713.71

Ref: 7W-GA4947

Paromomycin sulphate

CAS: 1263-89-4

Paromomycin sulphate

Fórmula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Pureza: Ph - 6 loss on drying: 3.1% (Typical Value in Batch COA)

Forma y color: white to faint yellow powder

Peso molecular: 713.71g/mol

Ref: 54-BIP0141

Paromomycin sulfate

Producto controlado

CAS: 1263-89-4

Fórmula: C₂₃H₄₅N₅O₁₄·H₂O₄S

Forma y color: Neat

Peso molecular: 713.71

Ref: 04-C15893500

Paromomycin Sulfate

CAS: 1263-89-4

Stability Hygroscopic
Applications an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);

Fórmula: C₂₃H₄₅N₅O₁₄·H₂O₄S

Forma y color: Neat

Peso molecular: 713.71

Ref: TR-P205650

Paromomycin sulfate

CAS: 1263-89-4

Paromomycin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating intestinal infections and leishmaniasis.

Fórmula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Pureza: ≥675Μg/Mg(On Dried Basis)

Forma y color: Yellow Powder

Peso molecular: 615.63 g/mol

Ref: 3D-AP31110

Paromomycin sulfate, Antibiotic for Culture Media Use Only

CAS: 1263-89-4

Paromomycin sulfate is an antibiotic used for culture media to control bacterial contamination of mediums and other laboratory substances. Most Gram-negative bacteria strains are sensitive to paromomycin sulfate, showing a low sensitivity (≀10%) in Enterobacteriaceae, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae and Serratia marcescens. Paromomycin sulfate is also used in the treatment of colorectal cancer by blocking DNA synthesis through inhibition of protein synthesis in susceptible cells. This can result in reduced damage in colon tumor cells within the body, although it may have neurotoxic effects on brain tissue. Furthermore, it has anti-inflammatory properties when given orally or intravenously at therapeutic doses. Acridine orange can be used to identify sulfuric acid resistant gram.

Fórmula: C₂₃H₄₇N₅O₁₈S

Pureza: Min. 95.0 Area-%

Peso molecular: 713.71 g/mol

Ref: 3D-Q-201537

Paromomycin Sulfate (PRM)

CAS: 1263-89-4

Fórmula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Forma y color: White to off-white, Powder

Peso molecular: 713.17

Ref: SR-27436

Paromomycin sulfate

CAS: 1263-89-4

Pureza: 95+%

Peso molecular: 713.710022

Ref: 10-F806731

Neomycin sulfate EP Impurity E

CAS: 1263-89-4

Fórmula: C₂₃H₄₅N₅O₁₄H₂SO₄

Peso molecular: 615.63 : 98.07

Ref: ST-EA-CP-N53005