CAS 128545-09-5

N-[(9H-Fluoren-9-ilmetoxi)carbonil]-3-(trifenilmetil)-L-histidina

Descripción:

N-[(9H-Fluoren-9-ilmetoxi)carbonil]-3-(trifenilmetil)-L-histidina, comúnmente conocido como Fmoc-His(Trt)-OH, es una forma protegida del aminoácido histidina utilizada principalmente en la síntesis de péptidos. Este compuesto presenta un grupo protector de fluorenilmetoxicarbonilo (Fmoc), que se utiliza ampliamente para la protección temporal de grupos amino durante la síntesis de péptidos. El grupo triphenylmethyl (Trt) proporciona protección adicional para la cadena lateral de la histidina, mejorando la estabilidad y previniendo reacciones no deseadas. La presencia de estos grupos protectores permite reacciones de desprotección y acoplamiento selectivas, facilitando el ensamblaje de péptidos complejos. Fmoc-His(Trt)-OH es típicamente un sólido blanco a blanco sucio y es soluble en disolventes orgánicos como el dimetilformamida (DMF) y el dimetilsulfóxido (DMSO), pero menos soluble en agua. Su estabilidad bajo condiciones estándar de acoplamiento de péptidos lo convierte en un intermediario valioso en el campo de la química orgánica y medicinal, particularmente en el desarrollo de terapias basadas en péptidos.

Fórmula: C₄₀H₃₃N₃O₄

InChI: InChI=1/C40H33N3O4/c44-38(45)37(42-39(46)47-26-36-34-22-12-10-20-32(34)33-21-11-13-23-35(33)36)24-31-25-41-27-43(31)40(28-14-4-1-5-15-28,29-16-6-2-7-17-29)30-18-8-3-9-19-30/h1-23,25,27,36-37H,24,26H2,(H,42,46)(H,44,45)/p-1/t37-/m0/s1

Clave InChI: InChIKey=LCDUPKDPUSBXAY-QNGWXLTQSA-N

SMILES: C(N1C(C[C@H](NC(OCC2C=3C(C=4C2=CC=CC4)=CC=CC3)=O)C(O)=O)=CN=C1)(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7

Sinónimos:

• (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(1-trityl-1H-imidazol-5-yl)propanoate
• <span class="text-smallcaps">L</span>-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-
• Fmoc-His(Trt)-OH
• Fmoc-L-His(Trt)-OH
• N(alpha)-fmoc-N(im)-trityl-L-histidine
• N-FMOC-3-(triphenylmethyl)-L-histidine
• N-Fmoc-N'-trityl-L-histidine
• N-[(9H-Fluoren-6-ylmethoxy)carbonyl]-3-(triphenylmethyl)-L-histidine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-<span class="text-smallcaps">L</span>-histidine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-tritylhistidine
• N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-trityl-L-histidine
• N-alpha-(9-fluorenylmethyloxycarbonyl)-N-im-trityl-L-histidine
• N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-L-histidine
• L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-
• N-ALPHA-FMOC--TRITYL-L-HISTIDINE
• FMOC-L-HIS(1-TRT)-OH
• N-[(9H-Fluoroen-6-ylmethoxy)carbonyl]-3-(triphenylmethyl)-L-histidine
• N-FMOC-3-(triphenylmethyl)-L-histidine USP/EP/BP
• Nalpha-fluorenylmethoxycarbonyl-im-trityl-L-histidine
• (S)-2-((((9H-Fluoren-3-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-5-yl)propanoic acid
• NALPHA-9-Fluorenylmethoxycarbonyl-NPI-trityl-L-histidine
• na-fmoc-im-trityl-L-histidine

L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-

CAS: 128545-09-5

Fórmula: C₄₀H₃₃N₃O₄

Peso molecular: 619.7077

Ref: IN-DA000Y76

Fmoc-His(Trt)-OH

CAS: 128545-09-5

Fmoc-His(Trt)-OH is a synthetic antimicrobial peptide that belongs to the class of acetylcholine. The peptide was found to inhibit the growth of a number of bacterial genera, including Pseudomonas, Acinetobacter and Burkholderia. The sequence of Fmoc-His(Trt)-OH is acetylated at the N-terminus and amidated at the C-terminus. This peptide has been found to have a broad spectrum of activity against drug resistant bacteria. It has also been shown to be active against mammalian cells in addition to bacterial cells, suggesting it may have therapeutic potential for humans as well as animals.

Fórmula: C₄₀H₃₃N₃O₄

Pureza: Min. 98.0 Area-%

Peso molecular: 619.73 g/mol

Ref: 3D-FLH-1740-PI