CAS 129-49-7

Maleato de metisergida

Descripción:

Maleato de metisergida es un compuesto sintético conocido principalmente por su uso en el tratamiento de migrañas y cefaleas en racimo. Es un derivado del ácido lisérgico y actúa como un antagonista del receptor de serotonina, particularmente en los sitios de receptor 5-HT2. La sustancia aparece como un polvo cristalino blanco a blanco sucio y se administra típicamente en forma de tabletas. Maleato de metisergida se caracteriza por su relativamente baja solubilidad en agua, lo que puede influir en su biodisponibilidad y farmacocinética. Tiene una vida media moderada, lo que permite una dosificación una o dos veces al día en entornos clínicos. Sin embargo, el uso prolongado puede llevar a efectos secundarios, incluyendo fibrosis retroperitoneal e hipertensión pulmonar, lo que requiere un monitoreo cuidadoso de los pacientes. Debido a estos posibles efectos adversos, su uso se ha vuelto menos común y a menudo se considera cuando otros tratamientos han fallado. Maleato de metisergida se clasifica en la categoría de alcaloides de ergot, que son conocidos por sus propiedades vasoconstrictoras.

Fórmula: C₂₁H₂₇N₃O₂·C₄H₄O₄

InChI: InChI=1/C21H27N3O2.C4H4O4/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14;5-3(6)1-2-4(7)8/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15+,19-;/m1./s1

SMILES: CN1C2=C3C(C=4[C@@](CC3=C1)(N(C)C[C@H](C(N[C@@H](CC)CO)=O)C4)[H])=CC=C2.C(=C\C(O)=O)\C(O)=O

Sinónimos:

• (+)-N-[(1-Hydroxymethyl)propyl]-1-methyl-<span class="text-smallcaps">D</span>-lysergamide bimaleate
• (8beta)-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide (2Z)-but-2-enedioate (salt)
• (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-1,6-dimethyl-9,10-didehydroergoline-8-carboxamide
• 1-Methyl-<span class="text-smallcaps">D</span>-lysergic acid butanolamide bimaleate
• Deseril-retard
• Desernil
• Desernil bimaleate
• Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8β)-, (2Z)-2-butenedioate (1:1)
• Ergoline-8-carboxamide, 9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8β)-, (2Z)-2-butenedioate (1:1) (salt)
• Ergoline-8-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethyl-, [8β(S)]-, (Z)-2-butenedioate (1:1) (salt)
• Ergoline-8β-carboxamide, 9,10-didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethyl-, maleate (1:1) (salt)
• Lysergamide, N-[1-(hydroxymethyl)propyl]-1-methyl-, maleate
• Methysergide Hydrogen Maleate
• Methysergide bimaleate
• NSC 186061

Methysergide Maleate

CAS: 129-49-7

Alkaloids of rye ergot and their derivatives; salts the

Fórmula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Forma y color: Powder

Peso molecular: 469.22129

Ref: 45-1440003

Methysergide maleate salt

CAS: 129-49-7

Fórmula: C₂₅H₃₁N₃O₆

Pureza: ≥ 99.0% (anhydrous)

Forma y color: White to off-white crystalline powder

Peso molecular: 469.53

Ref: 7W-GP2886

Methysergide Maleate

Producto controlado

CAS: 129-49-7

Stability Hygroscopic
Applications Methysergide Maleate acts as a serotonin antagonist with potential application antidepression medication. It is a 5-HT antagonist.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Masalov, I. et al.: J. Evol. Biochem. Phys., 48, 523 (2012); Fletcher, P. et al.: Psychopharm., 96, 236 (1988);

Fórmula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Forma y color: Neat

Peso molecular: 469.53

Ref: TR-M329350

Methysergide maleate monohydrate

Producto controlado

CAS: 129-49-7

Methylergide maleate monohydrate is a high-quality reagent that is useful as an intermediate for the synthesis of complex compounds. It is also a fine chemical that can be used in research and development. Methylergide maleate monohydrate has CAS No. 129-49-7, and it can be used to produce speciality chemicals or reaction components. It has a wide range of applications, such as being a versatile building block in organic synthesis and being a reaction component for the production of pharmaceuticals or agrochemicals.

Fórmula: C₂₅H₃₃N₃O₇

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 487.55 g/mol

Ref: 3D-FM39378

Methysergide maleate

Producto controlado

CAS: 129-49-7

Methysergide is a drug that has been used in the treatment of chronic schizophrenia and other neurological disorders. It is an antagonist of glutamate, which inhibits the release of 5-HT (serotonin) and thereby reduces the concentration of this neurotransmitter in the brain. Methysergide has also been shown to inhibit the production of carcinoid syndrome and gamma-aminobutyric acid (GABA). Methysergide is related to estradiol benzoate, which is used to treat autoimmune diseases such as systemic lupus erythematosus (SLE). Symptoms may include fever, joint pain, photosensitivity, skin rash, muscle pain, and weight loss. The pharmacological treatment for these symptoms includes methotrexate or corticosteroids.

Fórmula: C₂₁H₂₇N₃O₂·C₄H₄O₄

Pureza: Min. 95%

Peso molecular: 469.53 g/mol

Ref: 3D-FM75152

Methysergide maleate

CAS: 129-49-7

Methysergide prevents migraines/cluster headaches; treats serotonin syndrome, carcinoid-induced diarrhea; risk of fibrosis limits use.

Fórmula: C₂₅H₃₁N₃O₆

Pureza: 98%

Forma y color: White To Off-White

Peso molecular: 469.54

Ref: TM-T21423

Methysergide maleate

CAS: 129-49-7

Methysergide maleate

Fórmula: C₂₁H₂₇N₃O₂

Pureza: 72.6%

Forma y color: Off White Solid

Peso molecular: 353.21033

Ref: 47-409