CAS 129203-60-7

iberiotoxina de buthus tamulus

Descripción:

La iberiotoxina, derivada del veneno del escorpión rojo indio (Buthus tamulus), es una potente neurotoxina conocida por su inhibición selectiva de ciertos canales de potasio, particularmente los canales de potasio dependientes de voltaje (Kv) en tejidos excitables. Esta característica la convierte en una herramienta valiosa en neurofarmacología para estudiar la función de los canales iónicos y los roles fisiológicos de los canales de potasio en varios procesos celulares. La iberiotoxina exhibe una alta afinidad por el canal Kv1.3, que está implicado en respuestas inmunitarias y excitabilidad neuronal. La estructura de la toxina se caracteriza por una cadena polipeptídica que se pliega en una conformación tridimensional específica, lo que le permite interactuar de manera efectiva con sus canales objetivo. Su mecanismo de acción implica unirse al canal y prevenir el flujo de iones de potasio, lo que puede llevar a una despolarización prolongada de neuronas y células musculares. Debido a sus potentes efectos, la iberiotoxina también es de interés en investigaciones relacionadas con el dolor, la inflamación y aplicaciones terapéuticas potenciales, aunque su uso está principalmente confinado a entornos de laboratorio debido a su toxicidad.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

InChI: InChI=1/C179H274N50O55S7/c1-87(2)65-111-155(261)208-112(66-93-33-15-13-16-34-93)146(252)195-77-133(239)225-139(88(3)4)172(278)213-117(71-136(244)245)158(264)199-100(44-31-62-190-178(186)187)144(250)193-75-131(237)198-102(40-22-27-58-181)148(254)219-124(167(273)205-109(56-64-285-12)145(251)194-76-132(238)197-101(39-21-26-57-180)147(253)200-105(43-25-30-61-184)151(257)220-123-81-286-288-83-125(221-152(258)106(203-166(123)272)45-32-63-191-179(188)189)169(275)210-113(68-95-46-48-97(234)49-47-95)156(262)206-110(177(283)284)50-53-129(185)235)82-287-291-86-128(168(274)202-104(42-24-29-60-183)150(256)212-116(70-135(242)243)159(265)207-111)224-175(281)142(91(9)10)228-164(270)121(79-231)216-157(263)115(69-96-74-192-99-38-20-19-37-98(96)99)211-170(276)126-84-289-290-85-127(171(277)217-122(80-232)165(271)227-141(90(7)8)174(280)218-120(78-230)163(269)201-103(41-23-28-59-182)149(255)204-108(154(260)222-126)52-55-134(240)241)223-160(266)118(72-137(246)247)214-173(279)140(89(5)6)226-162(268)119(73-138(248)249)215-176(282)143(92(11)233)229-161(267)114(67-94-35-17-14-18-36-94)209-153(259)107-51-54-130(236)196-107/h13-20,33-38,46-49,74,87-92,100-128,139-143,192,230-234H,21-32,39-45,50-73,75-86,180-184H2,1-12H3,(H2,185,235)(H,193,250)(H,194,251)(H,195,252)(H,196,236)(H,197,238)(H,198,237)(H,199,264)(H,200,253)(H,201,269)(H,202,274)(H,203,272)(H,204,255)(H,205,273)(H,206,262)(H,207,265)(H,208,261)(H,209,259)(H,210,275)(H,211,276)(H,212,256)(H,213,278)(H,214,279)(H,215,282)(H,216,263)(H,217,277)(H,218,280)(H,219,254)(H,220,257)(H,221,258)(H,222,260)(H,223,266)(H,224,281)(H,225,239)(H,226,268)(H,227,271)(H,228,270)(H,229,267)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,283,284)(H4,186,187,190)(H4,188,189,191)

SMILES: CC(C)CC1C(=NC(Cc2ccccc2)C(=NCC(=NC(C(C)C)C(=NC(CC(=O)O)C(=NC(CCCNC(=N)N)C(=NCC(=NC(CCCCN)C(=NC(CSSCC(C(=NC(CCCCN)C(=NC(CC(=O)O)C(=N1)O)O)O)N=C(C(C(C)C)N=C(C(CO)N=C(C(Cc1c[nH]c2ccccc12)N=C(C1CSSCC(C(=NC(CO)C(=NC(C(C)C)C(=NC(CO)C(=NC(CCCCN)C(=NC(CCC(=O)O)C(=N1)O)O)O)O)O)O)N=C(C(CC(=O)O)N=C(C(C(C)C)N=C(C(CC(=O)O)N=C(C(C(C)O)N=C(C(Cc1ccccc1)N=C(C1CCC(=N1)O)O)O)O)O)O)O)O)O)O)O)C(=NC(CCSC)C(=NCC(=NC(CCCCN)C(=NC(CCCCN)C(=NC1CSSCC(C(=NC(Cc2ccc(cc2)O)C(=NC(CCC(=N)O)C(=O)O)O)O)N=C(C(CCCNC(=N)N)N=C1O)O)O)O)O)O)O)O)O)O)O)O)O)O)O

Sinónimos:

• Iberiotoxin, Buthus tamulus
• Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH (Disulfide bonds between Cys7 and Cys28/Cys13 and Cys33/ Cys17 and Cys35)
• Iberiotoxin

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin (IbTx), from the venom of the scorpion Buthus tamulus, shows 68% sequence homology with charybdotoxin, another scorpion-derived peptidyl toxin. Although these two toxins both inhibit the high conductance Ca²⁺ activated K⁺ channel, they appear to bind at different sites on the channel and modulate channel activity by different mechanisms. Thus, iberiotoxin can be used to selectively study the function of the high conductance Ca²⁺ activated K⁺ channel.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: > 95%

Forma y color: Whitish Powder

Peso molecular: 4230.91

Ref: 01-4030755

2-(2-{[10-(2-{2-[2-(2-{[7,34-bis(4-aminobutyl)-25-benzyl-13-(3-carbamimidamidopropyl)-16,31-bis(carboxymethyl)-28-(2-methylpropyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-19-(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriaco

CAS: 129203-60-7

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: ≥95%

Peso molecular: 4230.8479

Ref: IN-DA000YY4

Iberiotoxin

CAS: 129203-60-7

Selective blocker of the big conductance Ca2+-activated K+ channel.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 4230

Ref: TM-TP2014

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin a synthetic scorpion toxin sourced from the Buthus tamulus scorpion, has disufide bonds formed between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35. This prodict can be used as a Ca2+-Activated K+ Channel Blocker (Maxi-K+ Channel Blocker). This peptide can be used in pharmacological studies to investigate the effects of Iberiotoxin on various ion channels and receptors.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: Min. 95%

Peso molecular: 4,230.8 g/mol

Ref: 3D-PIB-3813-PI

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin is a neurotoxin that is synthesized by the bacterium Clostridium botulinum. It inhibits the activity of a number of enzymes, including protein kinase C and cyclase, but has no effect on phosphatases. Iberiotoxin has been shown to be effective against models systems of bowel disease, such as colonic inflammation and ulceration. Iberiotoxin binds to specific neuronal receptors in the central nervous system, leading to inhibition of intracellular calcium levels, which may play an important role in the mechanisms of action for this toxin.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: Min. 95%

Peso molecular: 4,230.86 g/mol

Ref: 3D-FI110468

Iberiotoxin

CAS: 129203-60-7

Iberiotoxin a synthetic scorpion toxin sourced from the Buthus tamulus scorpion, has disufide bonds formed between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35. This prodict can be used as a Ca2+-Activated K+ Channel Blocker (Maxi-K+ Channel Blocker). This peptide can be used in pharmacological studies to investigate the effects of Iveriotoxin on various ion channels and receptors. This product is available as a 0.1mg vial.

Fórmula: C₁₇₉H₂₇₄N₅₀O₅₅S₇

Pureza: Min. 95%

Peso molecular: 4,230.8 g/mol

Ref: 3D-PIB-4235-S