CAS 130-26-7

Clioquinol

Descripción:

Clioquinol, con el número CAS 130-26-7, es un compuesto orgánico que pertenece a la clase de los derivados de quinolina. Se reconoce principalmente por su uso como agente antimicrobiano y se ha empleado en el tratamiento de diversas infecciones gastrointestinales. Clioquinol presenta una apariencia cristalina amarilla y es soluble en disolventes orgánicos, como el etanol y el cloroformo, pero tiene una solubilidad limitada en agua. El compuesto posee propiedades antibacterianas y antifúngicas, lo que lo hace efectivo contra una variedad de patógenos. Sin embargo, su uso se ha asociado con una posible neurotoxicidad, lo que ha llevado a restricciones en sus aplicaciones clínicas. Clioquinol actúa quelando iones metálicos, lo que puede interrumpir el metabolismo microbiano. Su estructura química incluye un anillo de quinolina y un grupo hidroxilo, lo que contribuye a su actividad biológica. Debido a su importancia histórica y las controversias que rodean su seguridad, Clioquinol sigue siendo objeto de investigación, particularmente en el contexto de enfermedades neurodegenerativas y sus posibles roles terapéuticos.

Fórmula: C₉H₅ClINO

InChI: InChI=1/C10H6ClIO/c11-8-5-9(12)10(13)7-4-2-1-3-6(7)8/h1-5,13H

Clave InChI: InChIKey=QCDFBFJGMNKBDO-UHFFFAOYSA-N

SMILES: OC=1C2=C(C(Cl)=CC1I)C=CC=N2

Sinónimos:

• 5-Chloro-7-iodo-8-hydroxyquinoline
• 5-Chloro-7-iodo-8-oxyquinoline
• 5-Chloro-7-iodo-8-quinolinol
• 5-Chloro-7-iodoquinolin-8-ol
• 7-Iodo-5-chloro-8-hydroxyquinoline
• 7-Iodo-5-chloroxine
• 8-Hydroxy-7-iodo-5-chloroquinoline
• 8-Quinolinol, 5-chloro-7-iodo-
• Alchloquin
• Amebil
• Amoenol
• Bactol
• Barquinol
• Budoform
• Chinoform
• Chloroiodoquin
• Chloroiodoquine
• Chlorojodochin
• Cifoform
• Clioquinol
• Cliquinol
• Cort-Quin
• Dioquinol
• Dizenterol
• Eczecidin
• Emaform
• Entero-Vioform
• Enteroquinol
• Enteroseptol
• Enterozol
• Entrokin
• Hi-Eneterol
• Hi-Enterol
• Iodenterol
• Iodochlorhydroxyquin
• Iodochlorhydroxyquinol
• Iodochlorohydroxyquin
• Iodochlorohydroxyquinoline
• Iodochloroquine
• Iodochloroxine
• Iodochloroxyquinoline
• Iodoenterol
• Iodoxyquinoline
• Lekosept
• NSC 3531
• NSC 74938
• Nioform
• Quin-O-Creme
• Quinambicide
• Quinidochlor
• Quiniodochlor
• Quinoform
• Quinoform (antiseptic)
• Rheaform
• Rheaform Boluses
• Rometin
• Vioform
• Vioformio
• 5-Chlor-7-jod-8-hydroxy-chinolin
• AKOS B020410
• ala-quin
• 5-chloro-7-iodo-8-quinolino
• alchoquin
• chloroiodeoquim
• N-IODO-5-CHLORO-8-HYDROXYQUINOLINE

5-Chloro-8-hydroxy-7-iodoquinoline

CAS: 130-26-7

Fórmula: C₉H₅ClINO

Pureza: >97.0%(T)

Forma y color: Light yellow to Brown to Dark green powder to crystal

Peso molecular: 305.50

Ref: 3B-C0187

Clioquinol

CAS: 130-26-7

Forma y color: Neat

Ref: 61-FOR0312.00

CLIOQUINOL CRS

CAS: 130-26-7

CLIOQUINOL CRS

Fórmula: C₉H₅ClINO

Forma y color: White. Whitish. Yellow. Dark. Powder.

Peso molecular: 305.4996

Ref: 41-Y0000364

Clioquinol

CAS: 130-26-7

Clioquinol

Fórmula: C₉H₅ClINO

Pureza: 99.9%

Forma y color: Off-White

Peso molecular: 304.91044

Ref: 47-84

Clioquinol

CAS: 130-26-7

Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused

Fórmula: C₉H₅ClINO

Forma y color: Powder

Peso molecular: 304.91044

Ref: 45-1138201

5-Chloro-7-Iodoquinolin-8-ol

CAS: 130-26-7

Fórmula: C₉H₅ClINO

Pureza: 97%

Forma y color: Solid

Peso molecular: 305.4996

Ref: IN-DA003MOE

Clioquinol

CAS: 130-26-7

Clioquinol: oral, lipophilic copper-binder; halogenated quinoline with antifungal, antiparasitic, and possible antitumor uses.

Fórmula: C₉H₅ClINO

Pureza: 97.02%

Forma y color: Brownish-Yellow Bulky Powder Decomposes At 178-179°C Used As A Topical Anti-Infective

Peso molecular: 305.5

Ref: TM-T0876

Clioquinol

CAS: 130-26-7

Fórmula: C₉H₅ClINO

Pureza: ≥ 95.0%

Forma y color: White to light-yellow, yellow or brown powder or crystals

Peso molecular: 305.49

Ref: 7W-GP1671

Clioquinol

CAS: 130-26-7

Clioquinol

Pureza: ≥95%

Peso molecular: 305.5g/mol

Ref: 54-BUP17767

5-Chloro-8-hydroxy-7-iodoquinoline

CAS: 130-26-7

5-Chloro-8-hydroxy-7-iodoquinoline

Fórmula: C₉H₅ClINO

Pureza: ≥95%

Forma y color: cream powder

Peso molecular: 305.50g/mol

Ref: 54-OR28788

5-Chloro-7-iodoquinolin-8-ol

CAS: 130-26-7

Pureza: 97%

Forma y color: Solid

Peso molecular: 305.5

Ref: 10-F236842

Clioquinol

Producto controlado

CAS: 130-26-7

Fórmula: C₉H₅ClINO

Forma y color: Neat

Peso molecular: 305.50

Ref: 86-MM0312.00

Clioquinol

CAS: 130-26-7

Fórmula: C₉H₅ClINO

Peso molecular: 305.50

Ref: 4Z-C-805

Clioquinol

Producto controlado

CAS: 130-26-7

Applications Clioquinol is used as an antiparasitic compound, known to induce apoptosis in leukemia and myeloma cells.
References Cao, B. et al.: J. Biol. Chem., 288, 34181 (2013); Chen, Z. et al.: Eur J. Med. Chem., 68, 454 (2013);

Fórmula: C₉H₅ClINO

Forma y color: Neat

Peso molecular: 305.50

Ref: TR-C581100

5-Chloro-7-iodo-8-hydroxyquinoline

CAS: 130-26-7

5-Chloro-7-iodo-8-hydroxyquinoline is a metal chelate that has been shown to have pharmacological effects in experimental animals. It has antioxidative properties and can protect against oxidative injury. 5-Chloro-7-iodo-8-hydroxyquinoline was found to be toxic in various animal models, including the neuronal death and mitochondrial membrane potential. This toxicity may be due to its ability to inhibit the activity of DNA polymerase and protein synthesis. The compound also showed significant cytotoxicity at low concentrations, but had no significant cytotoxicity at higher concentrations. 5-Chloro-7-iodo-8-hydroxyquinoline is similar in structure to clioquinol, which has been shown to have neurotoxic effects in humans.

Fórmula: C₉H₅ClINO

Pureza: Min. 95 Area-%

Forma y color: Powder

Peso molecular: 305.5 g/mol

Ref: 3D-FC40594

Clioquinol - Bio-X ™

CAS: 130-26-7

Clioquinol is an antifungal drug and antiprotozoal drug that has been shown to inhibit the activity of protein kinase-3 and to promote apoptosis. This compound has also been found to improve iron homeostasis, which may be due to its ability to counteract the effects of oxidative stress on the mitochondria. Additionally, it has been shown to have anti-fungal properties against opportunistic fungal pathogens such as Candida albicans. Clioquinol is extracted from a plant called "Clioquinia rosea" and is produced by a chemical reaction with 2-chloroethanol.

Fórmula: C₉H₅ClINO

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 305.5 g/mol

Ref: 3D-BC167259

5-Chloro-7-Iodo-8-Quinolinol (Clioquinol, Iodochlorohydroxyquinoline) ExiPlus, Multi-Compendial, 97-103%

CAS: 130-26-7

Fórmula: C₉H₅ClINO

Pureza: 97.0-103.0%

Forma y color: White to Light Yellow to Light Beige, Powder or Crystals, Clear

Peso molecular: 305.5

Ref: SR-71848