CAS 13292-46-1

rifampicina

Descripción:

rifampicina, con el número CAS 13292-46-1, es un antibiótico semisintético que pertenece a la clase de las rifamicinas. Se utiliza principalmente para tratar infecciones bacterianas, particularmente la tuberculosis y la lepra, al inhibir la síntesis de ARN bacteriano. El compuesto presenta un color rojo-anaranjado y es conocido por su naturaleza lipofílica, lo que le permite penetrar eficazmente en las membranas celulares. rifampicina tiene una solubilidad relativamente baja en agua, pero es soluble en disolventes orgánicos como el etanol y la acetona. Su mecanismo de acción implica la unión a la subunidad beta de la ARN polimerasa bacteriana, impidiendo así la transcripción del ADN en ARN. Este antibiótico a menudo se administra en combinación con otros medicamentos para prevenir el desarrollo de resistencia. Además, rifampicina se metaboliza en el hígado y puede inducir enzimas del citocromo P450, afectando el metabolismo de otros medicamentos. Debido a sus potentes efectos y posibles efectos secundarios, incluida la hepatotoxicidad y las interacciones con otros medicamentos, es esencial un monitoreo cuidadoso durante el tratamiento.

Fórmula: C₄₃H₅₈N₄O₁₂

InChI: InChI=1/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20?/t21?,23-,24-,25-,29+,34+,35-,39+,43+/m1/s1

Clave InChI: InChIKey=JQXXHWHPUNPDRT-ZNQWNCHJSA-N

SMILES: OC1=C2C3=C4O[C@@](C)(C3=O)O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(\C)/C(=O)NC(C(O)=C2C(O)=C4C)=C1C=NN5CCN(C)CC5

Sinónimos:

• (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan, rifamycin deriv.
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-, 21-acetate
• 2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-, 21-acetate
• 3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin
• 3-[(4-Methyl-1-piperazinyl)iminomethyl]rifamycin SV
• 5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)-naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate
• Abrifam
• Ba 41166/E
• Dipicin
• Eremfat
• Famcin
• L 5103 Lepetit
• Nih 10782
• Nsc 113926
• R-Cin
• R/Amp
• RIF
• Refampicin
• Rifa
• Rifacap
• Rifactine
• Rifadin
• Rifadin I.V.
• Rifadine
• Rifaldazine
• Rifaldin
• Rifamate
• Rifamicin AMP
• Rifampicin SV
• Rifampicina
• Rifampicine
• Rifampin
• Rifamycin AMP
• Rifamycin SV Sodium
• Rifamycin, 3-[[(4-methyl-1-piperazinyl)imino]methyl]-
• Rifamyzin 3-(4-Methyl-Piperazinyl)Iminomethyl
• Rifandin
• Rifaprodin
• Rifater
• Rifobac
• Rifodex
• Rifoldin
• Rifoldine
• Riforal
• Rimactan
• Rimactane
• Rimapen
• Rimycin
• Sinerdol

Rifampicin

CAS: 13292-46-1

Inhibitor of RNA synthesis

Fórmula: C₄₃H₅₈N₄O₁₂

Pureza: Min. 95%

Forma y color: Orange Red Powder

Peso molecular: 822.94 g/mol

Ref: 3D-AR11351

Rifampicin (RFP) (Rifampin), 97-102%

CAS: 13292-46-1

Fórmula: C₄₃H₅₈N₄O₁₂

Pureza: 97-102%

Forma y color: A brick red to reddish brown, Crystalline powder

Peso molecular: 822.95

Ref: SR-12310

Rifampicin (RFP) (Rifampin) for cell culture, 97-102%, Endotoxin (BET) 0.05EU/mg

CAS: 13292-46-1

Fórmula: C₄₃H₅₈N₄O₁₂

Pureza: 97-102%

Forma y color: A brick red to reddish brown, Crystalline powder

Peso molecular: 822.95

Ref: SR-46143

Rifampicin, Antibiotic for Culture Media Use Only

CAS: 13292-46-1

Rifampicin is a drug that inhibits protein synthesis in bacteria and is used to treat tuberculosis. Rifampicin binds to the beta subunit of the bacterial RNA polymerase, inhibiting transcription and translation. It has been shown to inhibit the acetylcholine receptor function in rats, which may be related to its antituberculosis activity. Histopathological studies have shown that rifampicin inhibits the growth of human tumors in mice, including lung cancer, breast cancer, and leukemia. The drug is also being studied for its potential use in treating Alzheimer's disease. The pharmacokinetics and oral bioavailability of rifampicin have been studied and Rifampicin has been shown to be an effective anti-tuberculosis drug.

Fórmula: C₄₃H₅₈N₄O₁₂

Pureza: Min. 90.0 Area-%

Peso molecular: 822.94 g/mol

Ref: 3D-R-6000

RIFAMPICIN RS

CAS: 13292-46-1

RIFAMPICIN RS

Fórmula: C₄₃H₅₈N₄O₁₂

Peso molecular: 822.9402

Ref: 41-ICRS0409