CAS 13434-13-4

Actinonina

Descripción:

Actinonina, con el número CAS 13434-13-4, es un compuesto que se encuentra de forma natural y que es conocido principalmente por su papel como antibiótico. Se deriva de la bacteria *Streptomyces griseus* y exhibe notables propiedades antibacterianas, particularmente contra ciertas cepas de bacterias. Actinonina funciona inhibiendo la enzima aminopeptidasa N, que está involucrada en el metabolismo de proteínas, interrumpiendo así el crecimiento y la proliferación bacteriana. El compuesto se caracteriza por su estructura molecular específica, que incluye un marco bicíclico único que contribuye a su actividad biológica. Actinonina ha sido estudiado por sus posibles aplicaciones terapéuticas, particularmente en el tratamiento de infecciones causadas por cepas bacterianas resistentes. Además, se ha investigado por sus efectos en varios sistemas biológicos, lo que lo convierte en un tema de interés en química medicinal y farmacología. Su perfil de seguridad y eficacia en entornos clínicos continúan siendo áreas de investigación, mientras los científicos exploran sus posibles usos en la medicina moderna.

Fórmula: C₁₉H₃₅N₃O₅

InChI: InChI=1/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1

Clave InChI: InChIKey=XJLATMLVMSFZBN-VYDXJSESSA-N

SMILES: C([C@@H](NC([C@@H](CC(NO)=O)CCCCC)=O)[C@H](C)C)(=O)N1[C@H](CO)CCC1

Sinónimos:

• (2R)-N⁴-Hydroxy-N¹-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentylbutanediamide
• (2R)-N~4~-hydroxy-N~1~-{(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide
• 3-[[1-[[2-(Hydroxymethyl)-1-Pyrrolidinyl]-Carbonyl]-2-Methylpropyl]-Carbamoyl]-Octonohydroxamic Acid
• 3-[[1-[[2-(Hydroxymethyl)-1-Pyrrolidinyl]Carbonyl]-2-Methyl-Propyl]Carbamoyl]Octanohydroxamic Acid
• Actinonine
• Butanediamide, N⁴-hydroxy-N¹-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, (2R)-
• Butanediamide, N⁴-hydroxy-N¹-[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, stereoisomer
• Cona 57
• Hylpropyl)Carbamoyl)-
• N4-Hydroxy-N1-[(1S)-1[[(2S)-2-(hydroxymethyl)-1-pyrroldinyl]carbonyl]-2-methylpropyl]-2-pentyl-,(2R)-(9CI)
• N~4~-hydroxy-N~1~-{1-[2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide
• Octanohydroxamic acid, 3-[[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]-
• Octanohydroxamicacid,3-((1-((2-(Hydroxymethyl)-1-Pyrrolidinyl)Carbonyl)-2-Met
• Ro 06-1467
• (2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentylbutanediamide
• Butanediamide, N4-hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, (2R)-
• (-)-ACTINONIN
• Butanediamide, N4-hydroxy-N1-[1-[[2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-, stereoisomer
• (2R)-N'-hydroxy-N-[(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxo-butan-2-yl]-2-pentyl-butanediamide
• Actininin
• Butanediamide, N4-hydroxy-N1-(1S)-1-(2S)-2-(hydroxymethyl)-1-pyrrolidinylcarbonyl-2-methylpropyl-2-pentyl-, (2R)-
• (2R)-N'-hydroxy-N-[(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-pentylbutanediamide
• (R)-N4-Hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide
• (2R)-2-[2-(hydroxyamino)-2-keto-ethyl]-N-[(1S)-2-methyl-1-[(2S)-2-methylolpyrrolidine-1-carbonyl]propyl]enanthamide
• (2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]carbonyl]-2-Methylpropyl]-2-pentyl-butanediaMide

Actinonin

CAS: 13434-13-4

Fórmula: C₁₉H₃₅N₃O₅

Pureza: 95%

Forma y color: Solid

Peso molecular: 385.4983

Ref: IN-DA00800W

(R)-N4-Hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide

CAS: 13434-13-4

(R)-N4-Hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide

Pureza: 95%

Peso molecular: 385.51g/mol

Ref: 54-OR1073265

Actinonin

CAS: 13434-13-4

Fórmula: C₁₉H₃₅N₃O₅

Pureza: ≥ 97.0%

Forma y color: White to light yellow powder

Peso molecular: 385.50

Ref: 7W-GA8851

Actinonin

CAS: 13434-13-4

Actinonin is a natural product with antimicrobial activity. It inhibits the growth of bacteria by binding to their ribosomes and inhibiting protein synthesis. Actinonin has been shown to inhibit the growth of gram-positive species such as Streptococcus pyogenes, group A beta-hemolytic streptococci, and Enterococcus faecalis. Actinonin also inhibits a number of enzymes including target enzymes for antimicrobial agents such as penicillin and erythromycin. Actinonin has been shown to be a potential biomarker for bowel disease in humans by its ability to bind to mitochondria in cells from patients with inflammatory bowel disease. This compound binds to basic proteins, which are found in high concentrations in the cell nucleus of organisms including humans.

Fórmula: C₁₉H₃₅N₃O₅

Pureza: Min. 95%

Peso molecular: 385.51 g/mol

Ref: 3D-IAC-4157-PI

(-)-Actinonin

Producto controlado

CAS: 13434-13-4

Applications (-)-Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of aminopeptidase M and leucine aminopeptidase. Actinonin has observed to be an inhibitor of peptide deformylase, meprin A, and thermolysin. Actinonin also inhibits tumor cell invasion and matrix degradation along with displayed antitumor activity in vitro and in vivo as well as acting as an apoptotic inducer.
References Umezawa, H., et al.: J. Antibiot., 38, 1629 (1985), Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (2009), Berg, A., et al.: Biochem., 48, 1584 (2009), Kuehlmann, U., et al.: Life Sci., 84, 1 (2009),

Fórmula: C₁₉H₃₅N₃O₅

Forma y color: Neat

Peso molecular: 385.50

Ref: TR-A192000

(-)-Actinonin

CAS: 13434-13-4

Antibiotic peptide; inhibitor of aminopeptidase M and leucine aminopeptidase

Fórmula: C₁₉H₃₅N₃O₅

Pureza: Min. 95%

Peso molecular: 385.5 g/mol

Ref: 3D-FA17212

Actinonin

CAS: 13434-13-4

Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. It also induces apoptosis and inhibits aminopeptidase M, aminopeptidase N, and leucine aminopeptidase, as well as MMP-1, MMP-3, MMP-8, MMP-9, and meprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin exhibits antiproliferative and antitumor activities [1][2][3][4][5].

Fórmula: C₁₉H₃₅N₃O₅

Forma y color: Solid

Peso molecular: 385.5

Ref: TM-T14121