CAS 134395-00-9
:Éster tert-butilo de atorvastatina
Descripción:
Éster tert-butilo de atorvastatina, con el número CAS 134395-00-9, es un compuesto químico que sirve como intermediario en la síntesis de atorvastatina, un medicamento ampliamente utilizado para reducir los niveles de colesterol. Este compuesto se caracteriza por su grupo funcional éster, que contribuye a su reactividad y propiedades de solubilidad. Típicamente, Éster tert-butilo de atorvastatina es un sólido blanco a blanco sucio, y es soluble en disolventes orgánicos como metanol y etanol, pero menos soluble en agua. El grupo tert-butilo mejora la lipofilia de la molécula, lo que puede influir en sus propiedades farmacocinéticas. En términos de estabilidad, el compuesto es generalmente estable bajo condiciones de laboratorio estándar, pero puede ser sensible a la hidrólisis en presencia de humedad. Como intermediario, es crucial en la industria farmacéutica para la producción de atorvastatina, que funciona como un inhibidor de la HMG-CoA reductasa, reduciendo efectivamente la síntesis de colesterol en el hígado. Las condiciones adecuadas de manejo y almacenamiento son esenciales para mantener su integridad y eficacia durante los procesos de síntesis y formulación.
Fórmula:C37H43FN2O5
InChI:InChI=1S/C37H43FN2O5/c1-24(2)34-33(36(44)39-28-14-10-7-11-15-28)32(25-12-8-6-9-13-25)35(26-16-18-27(38)19-17-26)40(34)21-20-29(41)22-30(42)23-31(43)45-37(3,4)5/h6-19,24,29-30,41-42H,20-23H2,1-5H3,(H,39,44)/t29-,30-/m1/s1
Clave InChI:InChIKey=GCPKKGVOCBYRML-LOYHVIPDSA-N
SMILES:C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(OC(C)(C)C)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4
Sinónimos:- (3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid tert-butyl ester
- (4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-isopropyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dihydroxy-4-acetate
- (R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester
- 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, 1,1-dimethylethyl ester, (βR,δR)-
- 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, 1,1-dimethylethyl ester, [R-(R*,R*)]-
- L-2
- L2
- Atorvastatin Impurity 21
- (βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-DiMethylethyl Ester
- (R,dR)-2-(4-Fluorophenyl)-,d-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole
- Atorvastatin tert-Butyl Ester
- (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)
- Atorvastatin 1
- 7-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxy-heptanoic Acid tert-Butyl Ester
- (3R,5R)
- -tert-Butyl 7-(2-(4-fluorophenyl)
- (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-
- (4R-cis)-1,1-diMethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-isopropyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrro-1-yl]ethyl]-2,2-diMethyl-1,3-dihydroxy-4-acetate
- (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
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Encontrado 8 productos.
Atorvastatin tert-Butyl Ester (tert-butyl (3R,5R)-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate)
CAS:Heterocyclic compounds with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoiFórmula:C37H43FN2O5Forma y color:White Off-White SolidPeso molecular:614.3156(3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate
CAS:Fórmula:C37H43FN2O5Pureza:98%Forma y color:SolidPeso molecular:614.7461Atorvastatin EP Impurity N (Atorvastatin tert-Butyl Ester)
CAS:Fórmula:C37H43FN2O5Forma y color:White To Off-White SolidPeso molecular:614.76(bR,deltaR)-Atorvastatin tert-Butyl Ester (>90%)
CAS:Producto controlado<p>Applications An impurity arising in the synthesis of Atorvastatin. Atorvastatin Tert Butyl Ester<br></p>Fórmula:C37H43FN2O5Pureza:>90%Forma y color:NeatPeso molecular:614.75Atorvastatin-d5 tert-Butyl Ester
CAS:Producto controlado<p>Applications Atorvastatin-d5 tert-Butyl Ester is the labeled analogue of Atorvastatin tert-Butyl Ester (A791740), an impurity arising in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)<br></p>Fórmula:C37H38D5FN2O5Forma y color:NeatPeso molecular:619.78Atorvastatin tert-butyl ester
CAS:<p>Atorvastatin tert-butyl ester is an acid that is used to treat high cholesterol. It is a synthetic statin that inhibits the enzyme HMG-CoA reductase and blocks the production of cholesterol in the liver. This drug is administered orally, as a tablet or capsule, or in liquid form as a suspension. The drug has a bitter taste and evaporation may occur if it comes into contact with skin or clothes. Atorvastatin tert-butyl ester may be found in polymorphic forms (including dihydropyridine, dihydrospirocyclopentane, and dihydrobenzoquinoline). These forms are inactive, but can be activated by exposure to light or heat. These reactions produce an acidic compound that can react with other compounds to form new compounds.</p>Fórmula:C37H43FN2O5Pureza:Min. 95%Forma y color:White PowderPeso molecular:614.75 g/mol
