CAS 134418-28-3

Deshidroandrographólido

Descripción:

Deshidroandrographólido es un compuesto natural derivado de la planta Andrographis paniculata, comúnmente conocido por sus propiedades medicinales. Es un lactona diterpenoide bicíclica, caracterizada por su estructura compleja que incluye múltiples anillos y grupos funcionales. Este compuesto exhibe una variedad de actividades biológicas, incluyendo propiedades antiinflamatorias, antioxidantes y antimicrobianas, lo que lo hace de interés en la investigación farmacológica. Deshidroandrographólido ha sido estudiado por sus posibles efectos terapéuticos en diversas condiciones, incluyendo infecciones y enfermedades inflamatorias. Su mecanismo de acción a menudo implica la modulación de vías de señalización y la inhibición de citoquinas proinflamatorias. Además, se sabe que interactúa con varios objetivos biológicos, contribuyendo a sus diversos efectos farmacológicos. El compuesto se analiza típicamente utilizando técnicas como cromatografía y espectroscopía para determinar su pureza y concentración en entornos de investigación. En general, Deshidroandrographólido representa un área significativa de estudio en la química de productos naturales y el desarrollo de fármacos, destacando la importancia de los compuestos derivados de plantas en la medicina moderna.

Fórmula: C₂₀H₂₈O₅

InChI: InChI=1/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5-6,9,15-17,21-22H,1,4,7-8,10-12H2,2-3H3/b6-5+/t15-,16?,17-,19+,20+/m1/s1

Clave InChI: InChIKey=YIIRVUDGRKEWBV-CZUXAOBFSA-N

SMILES: C[C@]12[C@@]([C@@](CO)(C)[C@H](O)CC1)(CCC(=C)[C@@H]2C/C=C\3/C(=O)OC=C3)[H]

Sinónimos:

• (2R,5R,10R)-2,17-dihydroxy-20-oxo-9,19-didehydro-5,6,7,8,9,10,15-octahydro-20:5,10-dicycloretinal
• (3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone
• 14-(P)
• 14-Deoxy-11-dehydroandrographolide
• 2(3H)-Furanone, 3-[2-[(1S,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, (3E)-
• 2(3H)-Furanone, 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, [1R-[1α,2α,4aα,5β(E),8aβ]]-
• DEOXY-11,12-DiDehydroandrographolide
• Dehydroanddrographolide
• Dehydroandrographoline
• andrographolide, Dehydro-
• Dehydroandrographolide
• Dehydrographkide
• 2(3H)-Furanone,3-[2-[(1S,4aS,5R,6R,8aS)-decahydro-

(3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone

CAS: 134418-28-3

Fórmula: C₂₀H₂₈O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 332.4339

Ref: IN-DA009AGI

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide

Pureza: ≥98%

Peso molecular: 332.43g/mol

Ref: 54-BUP06369

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.

Fórmula: C₂₀H₂₈O₄

Pureza: 99.98%

Forma y color: Solid

Peso molecular: 332.43

Ref: TM-T2738

Dehydroandrographolide

CAS: 134418-28-3

Dehydroandrographolide is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity. It possesses activity against HBV DNA replication with IC50 values of 22.58 uM and low SI values of 8.7 ; it can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS.

Fórmula: C₂₀H₂₈O₄

Pureza: 95%~99%

Peso molecular: 332.44

Ref: BP-BP0459

Dehydroandrographolide

CAS: 134418-28-3

Fórmula: C₂₀H₂₈O₄

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 332.43

Ref: 7W-GP8945

Dehydroandrographolide

CAS: 134418-28-3

Lactone

Fórmula: C₂₀H₂₈O₄

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 332.44

Ref: 5G-89623

Dehydroandrographoline

CAS: 134418-28-3

Dehydroandrographolide is a natural product that has been used in traditional medicine to treat bowel disease, diabetes, and cancer. This compound is found in the plant Andrographis paniculata and has been shown to inhibit P-glycoprotein (P-gp) efflux transporter activity. Dehydroandrographolide also induces autophagy, which is the process by which cells degrade their own components under conditions of nutrient starvation or other stress. In addition, dehydroandrographolide succinate inhibits potassium channel activity and may be a potential anticancer agent. The analytical method for dehydroandrographolide succinate is based on an acid hydrolysis followed by high performance liquid chromatography with UV detection at λ max 218 nm.

Fórmula: C₂₀H₂₈O₅

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 348.43 g/mol

Ref: 3D-FD11384