CAS 134523-03-8

Atorvastatina cálcica

Descripción:

Atorvastatina cálcica es un compuesto farmacéutico utilizado principalmente como agente reductor de lípidos para manejar la hiperlipidemia y reducir el riesgo de enfermedades cardiovasculares. Pertenece a la clase de medicamentos conocidos como estatinas, que funcionan inhibiendo la enzima HMG-CoA reductasa, un jugador clave en la biosíntesis de colesterol en el hígado. Esta acción conduce a una disminución del colesterol de lipoproteínas de baja densidad (LDL) y triglicéridos, mientras que aumenta los niveles de colesterol de lipoproteínas de alta densidad (HDL). La atorvastatina se administra típicamente por vía oral y se absorbe bien en el tracto gastrointestinal. Su solubilidad se ve influenciada por el pH, con mejor solubilidad en condiciones ácidas. El compuesto se caracteriza por su fórmula molecular, que refleja su estructura compleja, y existe como una sal de calcio para mejorar su estabilidad y biodisponibilidad. Los efectos secundarios comunes pueden incluir dolor muscular, alteraciones en las enzimas hepáticas y trastornos gastrointestinales. Al igual que con todos los medicamentos, la atorvastatina debe usarse bajo supervisión médica, considerando las posibles interacciones con otros medicamentos y los perfiles de salud individuales de los pacientes.

Fórmula: C₆₆H₆₈Ca₂F₂N₄O₁₀

InChI: InChI=1/2C33H35FN2O5.2Ca.2H/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;;;/q;;;+2;;/p-2/t2*26-,27-;;;;/m11..../s1/r2C33H35FN2O5.CaH2.Ca/c2*1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;/h2*3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);1H2;/q;;;+2/p-2/t2*26-,27-;;/m11../s1

Clave InChI: InChIKey=BWFCZHDTTAYGNN-CNZCJKERSA-N

SMILES: C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(O)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4.[Ca]

Sinónimos:

• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5-Dihydroheptanoic Acid,calcium salt
• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5�CDihydroheptanoic Acid,calcium salt
• (3R,5R)-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl)Pyrrol-1-yl]-3,5�CDihydroheptanoic Acid,calcium salt(L-4)
• (R-(R*,R*))-, Atorvastatin calcium
• 1H-Pyrrole-1-Heptanoicacid,Beta,Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methy Calciumsalt(2:1),(R-(R*,R*))-Lethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-calcium salt (2: 1), (R-(R*,R*))-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), (βR,δR)-
• 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), [R-(R*,R*)]-
• 1H-Pyrrole-1-heptanoic acid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-calcium salt (2: 1)
• Atocor
• Atoraz
• Atorvastatin Ca
• Atorvastatin Calcium Anhydrous
• Atorvastatin Calsium
• Atorvastatin calcium (USAN)
• Atorvastatin calcium salt
• Atorvastatin hemicalcium
• Atorvastatin hemicalcium salt
• Atorvastatincalcuim
• Beta,Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-Calcium Salt(2:1)
• C08078
• Calcium (betaR,deltaR)-2-(p-fluorophenyl)-beta,delta-dihydroxy-5-isopr opyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoate (1:2)
• Ci-981
• D00887
• Delta-Dihydroxy-2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-Betcalci1H-Pyrrole-1-Heptanoicaci
• Drg-0321
• L-4
• Lipibec
• Lipitor
• Lipitor (TN)
• Lorvast
• Lowlip
• Ls-136974
• Pd 134298-38A
• Pd134298-38A
• Prevencor
• Rotacor
• Sortis
• Storvas
• Tahor
• Torvast
• Ym-548
• [R-(R*, R*)]-7-[2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-(Phenylaminocarbonyl)-1H-Pyrrol-1-Yl]-3,5-Dihydroxy-Heptanoic Acid Calcium Salt
• calcium (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-p ropan-2-yl-pyrrol-1-yl]-3,5-dihydroxy-heptanoate
• Atorvastatin calcium
• calciumsalt(2:1),(r-(r*,r*))-lethyl)-3-phenyl-4-((phenylamino)carbonyl)
• (3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl) Pyrrol-1-yl]-3 ,5-Dihydroheptanoic Acid, calcium salt (2:1) Trihydrate
• 3R ,5R )-7-[2-(4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Pheynylcarbamoyl) Pyrrol-1-yl]-3 ,5 ydroheptanoic Acid, calcium salt (2:1) Trihydrate
• 1h-pyrrole-1-heptanoicacid,beta,delta-dihydroxy-2-(4-fluorophenyl)-5-(1-methy
• Atrovastatin calcium
• (bR,dR)-2-(4-Fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid
• ATORVASTATINE CADIUM
• 3S,5S-Atorvastatin
• Atorvastatin Calclum
• ATORVASTATIN CALCIUM MM(CRM STANDARD)

Atorvastatin Calcium Salt Trihydrate

CAS: 134523-00-5, 134523-03-8, 344423-98-9

Fórmula: C₆₆H₆₈CaF₂N₄O₁₀·3H₂O

Pureza: >98.0%(HPLC)(N)

Forma y color: White to Almost white powder to crystal

Peso molecular: 1,209.41

Ref: 3B-A2476

Atorvastatin Calcium

CAS: 134523-03-8

Forma y color: Neat

Ref: 61-FOR0400.00

Atorvastatin calcium

CAS: 134523-03-8

Atorvastatin calcium

Fórmula: C₆₆H₆₈CaF₂N₄O₁₀

Pureza: 95.1%

Forma y color: White

Peso molecular: 1154.45294

Ref: 47-1267

1H-Pyrrole-1-heptanoicacid,2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-,calciumsalt(2:1),(βR,δR)-

CAS: 134523-03-8

Fórmula: C₆₆H₆₈CaF₂N₄O₁₀

Pureza: 98%

Forma y color: Solid

Peso molecular: 1155.3417

Ref: IN-DA00368S

Atorvastatin Calcium Salt

CAS: 134523-03-8

Fórmula: C₃₃H₃₄FN₂O₅·5Ca

Forma y color: White To Off-White Solid

Peso molecular: 557.65 0.5*40.08

Ref: 4Z-A-121

Atorvastatin calcium salt

CAS: 134523-03-8

Fórmula: C₃₃H₃₄FN₂O₅·5Ca·5H₂O

Pureza: 98.0 - 102.0 % (anhydrous basis)

Forma y color: White to almost white crystalline powder

Peso molecular: 604.69

Ref: 7W-GP5009

Atorvastatin calcium

CAS: 134523-03-8

Fórmula: C₃₃H₃₄FN₂O₅·Ca

Forma y color: Neat

Peso molecular: 1155.34

Ref: 04-C10318000

Atorvastatin Calcium

Producto controlado

CAS: 134523-03-8

Fórmula: C₃₃H₃₄FN₂O₅·Ca

Forma y color: Neat

Peso molecular: 1155.34

Ref: 86-MM0400.00

Atorvastatin Impurity 61

CAS: 134523-03-8

Fórmula: C₄₀H₄₇FN₂O₆

Forma y color: White To Off-White Solid

Peso molecular: 670.82

Ref: 4Z-A-12102

Atorvastatin hemicalcium salt

CAS: 134523-03-8

Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an orally HMG-CoA reductase inhibitor that lowers cholesterol. Cost-effective and quality-assured.

Fórmula: C₃₃H₃₄FN₂O₅Ca

Pureza: 99.27% - >99.99%

Forma y color: White Crystalline Powder

Peso molecular: 577.67

Ref: TM-T3116

Atorvastatin Calcium Salt

Producto controlado

CAS: 134523-03-8

Applications A selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Zhao Y et al. Medicine (Baltimore). 2017 Feb;96(7):e6104.Wu X et al. Carcinogenesis. 2017 Feb 16Sepehri Z et al. PLoS One. 2017 Feb 13;12(2):e0172404

Fórmula: C₃₃H₃₄FN₂O₅·Ca

Forma y color: White

Peso molecular: 1155.34

Ref: TR-A791750

Atorvastatin calcium

CAS: 134523-03-8

HMG-CoA reductase inhibitor; anti-hypercholesterolemia agent

Fórmula: C₆₆H₆₈CaF₂N₄O₁₀

Pureza: Min. 97 Area-%

Forma y color: White Powder

Peso molecular: 1,155.34 g/mol

Ref: 3D-FA57652

Atorvastatin calcium salt - Bio-X ™

CAS: 134523-03-8

Atorvastatin is an HMG-CoA reductase inhibitor that is used to lower lipid levels and to aid in the management of cardiovascular diseases. Animal studies have demonstrated that this drug has vasculoprotective properties.

Fórmula: (C₃₃H₃₅FN₂O₅)₂•Ca

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 1,157.36 g/mol

Ref: 3D-BA164226