CAS 136553-81-6

B Q-123

Descripción:

B Q-123, identificado por su número CAS 136553-81-6, es un compuesto químico que ha atraído la atención en varios campos, particularmente en la química medicinal y la farmacología. Se caracteriza por su estructura molecular específica, que contribuye a su actividad biológica única. B Q-123 es conocido por actuar como un antagonista selectivo de ciertos receptores, influyendo en varios procesos fisiológicos. Su solubilidad, estabilidad y reactividad son factores importantes que determinan su aplicación en la investigación y posibles usos terapéuticos. Además, B Q-123 puede exhibir interacciones específicas con otras biomoléculas, lo que puede ser crítico para su función en sistemas biológicos. Las pautas de seguridad y manejo son esenciales al trabajar con este compuesto, al igual que con cualquier sustancia química, para mitigar cualquier peligro potencial. En general, B Q-123 representa un compuesto significativo en el estudio de interacciones de receptores y desarrollo terapéutico, aunque la información detallada sobre sus aplicaciones y efectos específicos puede variar según la investigación en curso.

Fórmula: C₃₁H₄₂N₆O₇

InChI: InChI=1/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)

SMILES: CC(C)CC1C(=NC(Cc2c[nH]c3ccccc23)C(=NC(CC(=O)O)C(=O)N2CCCC2C(=NC(C(C)C)C(=N1)O)O)O)O

Sinónimos:

• cyclo(D-asp-pro-D-val-leu-D-trp)
• Cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu)
• D-alpha-aspartyl-L-prolyl-D-valyl-N-[(2R)-1-(1H-indol-3-yl)-3-oxopropan-2-yl]-4-methylidene-L-norvalinamide
• cyclo(D-alpha-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
• Cyclo(Alpha-Aspartylprolylvalylleucyltryptophyl)
• Bq-123 Sodium Salt
• Cyclo(D-Asp-L-Pro-D-Val-L-Leu-D-Trp-)
• ETA-RECEPTOR ANTAGONIST
• cyclo(Trp-Asp-Pro-Val-Leu)
• BQ-123 >=99%, sodium salt, lyophilized powder
• D-TRP-D-ASP-PRO-D-VAL-LEU
• BQ-123;BQ 123;BQ123
• BQ-518
• Cyclo[D-Asp-L-Pro-D-Val-L-Leu-D-Trp-]
• BQ-123
• C(DTRP-DASP-PRO-DVAL-LEU)
• 2-((3R,6S,9R,12R,17aS)-9-((1H-indol-3-yl)methyl)-6-isobutyl-3-isopropyl-1,4,7,10,13-pentaoxohexadecahydro-1H-pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecin-12-yl)acetic acid
• Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl
• BQ-123 SYNTHETIC >99% SELECTIVE ETA ENDO THE
• PMZ 2123
• M.W. 610.70 C31H42N6O7
• Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)
• CYCLO (-D-TRP-D-ASP-PRO-D-VAL-LEU) SODIUM SALT
• 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid
• CYCLO(D-ASP-PRO-D-VAL-LEU-DTRP NA)

BQ-123

CAS: 136553-81-6

BQ-123 is a potent endothelin antagonist with high selectivity for the ET-A receptor subtype.

Fórmula: C₃₁H₄₂N₆O₇

Pureza: 98.4%

Forma y color: Yellow

Peso molecular: 610.71

Ref: 01-4016690

Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl)

CAS: 136553-81-6

Fórmula: C₃₁H₄₂N₆O₇

Pureza: 98%

Forma y color: Solid

Peso molecular: 610.7012

Ref: IN-DA009ARV

2-((3R,6S,9R,12R,17As)-9-((1H-Indol-3-Yl)Methyl)-6-Isobutyl-3-Isopropyl-1,4,7,10,13-Pentaoxohexadecahydro-1H-Pyrrolo[1,2-A][1,4,7,10,13]Pentaazacyclopentadecin-12-Yl)Acetic Acid

CAS: 136553-81-6

2-((3R,6S,9R,12R,17As)-9-((1H-Indol-3-Yl)Methyl)-6-Isobutyl-3-Isopropyl-1,4,7,10,13-Pentaoxohexadecahydro-1H-Pyrrolo[1,2-A][1,4,7,10,13]Pentaazacyclopentadecin-12-Yl)Acetic Acid

Pureza: 98%

Peso molecular: 610.7g/mol

Ref: 54-OR1023197

BQ-123

CAS: 136553-81-6

BQ-123

Pureza: ≥95%

Peso molecular: 610.7g/mol

Ref: 54-BUP08189

BQ-123

CAS: 136553-81-6

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

Fórmula: C₃₁H₄₂N₆O₇

Pureza: 99.22% - ≥95%

Forma y color: Solid

Peso molecular: 610.7

Ref: TM-T6792

BQ-123-d7

CAS: 136553-81-6

Fórmula: C₃₁H₃₅D₇N₆O₇

Peso molecular: 617.75

Ref: 4Z-PB-200002

BQ-123 [Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)]

CAS: 136553-81-6

Fórmula: C₃₁H₄₂N₆O₇

Peso molecular: 610.71

Ref: 4Z-PB-200001

BQ-123-13C6-15N

CAS: 136553-81-6

Fórmula: C₂₅₁₃C₆H₄₂N₅₁₅NO₇

Peso molecular: 617.66

Ref: 4Z-PB-200003

BQ-123 Sodium Salt

CAS: 136553-81-6

BQ-123 is a cyclic peptide that blocks the endothelin-A receptor. It has been shown to be an effective treatment for pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and other inflammatory conditions. BQ-123 binds to the endothelin-A receptor, which is located on the surface of cells in many tissues throughout the body. When bound, it inhibits intracellular calcium concentrations by reducing voltage-gated calcium channels and prevents the release of neurotransmitters. BQ-123 also has a stabilizing effect on hydrogen bonds due to its charged side chains. This property may account for its ability to form stable complexes with other proteins, inhibiting their function.
BQ-123 has been shown to have an active binding site on cyclic AMP response element binding protein (CREB) that inhibits CREB activity, thereby reducing protein synthesis. It also blocks cyclic GMP (cGMP)-dependent protein kin

Fórmula: C₃₁H₄₂N₆O₇

Pureza: Min. 95%

Peso molecular: 610.70 g/mol

Ref: 3D-PED-3512-PI

BQ-123 Cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu)

CAS: 136553-81-6

BQ-123 is a cyclic peptide that has been shown to have a binding affinity for the serotonin receptor. The binding of BQ-123 to the receptor leads to a reduction in intracellular calcium concentration, which may be due to the inhibition of serine protease activity. This agent also inhibits the production of tumour necrosis factor-α (TNF-α) and has an inhibitory effect on cardiac contractility.

Fórmula: C₃₁H₄₂N₆O₇

Pureza: Min. 95%

Peso molecular: 610.7 g/mol

Ref: 3D-FB108394